Publications by authors named "Shin-Ichirou Horiguchi"
Article Synopsis
- The case discusses an annular pancreas where Wirsung's duct surrounds the duodenum and connects directly to the main pancreatic duct in the pancreas's body and tail.
- Histological examination revealed irregularly shaped islets of Langerhans with a high presence of pancreatic polypeptide (PP)-positive cells, highlighting a distinct area around the duodenum fused with a PP-poor region.
- An embryological theory is proposed that suggests incomplete rotation during pancreas development led to the duct formation and fusion issues between the ventral and dorsal pancreatic parts.
Background: Pancreatic cancer occurs in some patients with autoimmune pancreatitis (AIP). Significant K-ras mutations are frequently detected in the pancreas of AIP patients. AIP may be a pancreatic lesion of IgG4-related systemic disease.
View Article and Find Full Text PDFObjectives: To assess the relationship between autoimmune pancreatitis (AIP) and pancreatic cancer, we analyzed K-ras mutation in the pancreatobiliary tissues of patients with AIP.
Methods: An analysis of K-ras mutation and an immunohistochemical study were performed on the pancreas of 8 patients with AIP and 10 patients with chronic alcoholic pancreatitis and on the common bile duct and the gallbladder of 9 patients with AIP. K-ras mutation was analyzed in the pure pancreatic juice from 3 patients with AIP.
Cancer cells induce proliferation and local accumulation of immunosuppressive cells, such as FOXP3-positive cells known as regulatory T cells (Tregs), leading to tumor-induced immune tolerance. Although cancer chemotherapy is usually considered immunosuppressive, some chemotherapeutic agents activate an anticancer immune response. Therefore, we postulated that the number of tumor-infiltrating FOXP3-positive cells during primary systemic chemotherapy (PSC) correlates with therapeutic outcomes in patients with breast cancer.
View Article and Find Full Text PDFClinicopathologic features of ampullary carcinoma without jaundice.
J Clin Gastroenterol
February 2006
Goals: To evaluate clinicopathological features of ampullary carcinoma without jaundice.
Background: : Obstructive jaundice is the most common symptom of patients with ampullary carcinoma. However, some patients with ampullary carcinoma do not have jaundice at the time of diagnosis.
Context: Pancreas divisum is a congenital anomaly in which the ventral and dorsal pancreatic ducts do not communicate.
Case Report: Autopsy case of pancreas divisum with a history of heavy consumption of alcohol was presented. Pancreatography via the major duodenal papilla showed a short ventral pancreatic duct of 1 cm in length, and hypoplasia of the ventral pancreas was suspected.