Publications by authors named "Shin-Ichi Uchiyama"
Article Synopsis
- Carnitine is vital for transporting fatty acids into mitochondria for energy production, with most of it stored in muscles, which can be depleted in neuromuscular diseases.
- An 8-year-old boy with a form of congenital muscular dystrophy was given oral carnitine supplements, initially normalizing his serum levels, but later developed severe health issues, including coma and hypoglycemia.
- The case highlights that acute carnitine deficiency can occur in patients with muscle atrophy, even when serum levels seem normal, suggesting the need for treatment adjustments during illness.
A pediatric patient, who was given live-attenuated oral polio vaccine twice without distinct gait disturbance during infancy, begun to present limp at 3 years. His gait disturbance became remarkable with aging. At 7 years, he was unable to dorsiflex the left ankle, and presented flaccid monoplegia of the left lower extremity, and the left Achilles tendon reflex was diminished.
View Article and Find Full Text PDFBackground: Cholesterol is one of the main components of human cell membranes and constitutes an essential substance in the central nervous system, endocrine system, and its hormones, including sex hormones.
Patient: A 19-year-old male patient presented with failure to thrive, psychomotor deterioration, intractable epilepsy, hypogonadism, and cerebro-cerebello-bulbar degeneration. His serum level of cholesterol was low, ranging from 78.
Objective: Gangliosides are present in high concentrations in the nervous tissue, and some are observed in small amounts in many extraneural tissues and body fluids. Human milk may play important roles in energy supplementation, prophylaxis of infection, and brain development. For preterm infants, human milk gangliosides are also very important substances during the early lactation stage.
View Article and Find Full Text PDFBackground: The central nervous system (CNS) inflammation of Kawasaki disease (KD) has not been sufficiently evaluated in spite of the complications of irritability and CSF pleocytosis.
Patients And Methods: Cerebrospinal fluid (CSF) and serum inflammatory cytokine values were simultaneously examined in 10 patients (2.6 +/- 2.