Publications by authors named "Shin-A Jang"
Article Synopsis
- Pep27 from Streptococcus pneumoniae is a key virulence factor that causes the bacteria to self-destruct, but no well-defined monoclonal antibodies for it have been created.
- Researchers found two specific single-chain antibody variable fragments (E2 and F9) from a human scFv library, with binding strengths of 1.1 μM and 0.50 μM respectively, and they confirmed that these antibodies don’t react with unrelated proteins.
- The study identified specific amino acids on Pep27 for antibody binding, showing that E2 and F9 effectively detect Pep27 in conditions similar to those found in the human body, suggesting they're promising tools for diagnosing pneumococcal diseases.
Streptococcus pneumoniae is a major infectious agent responsible for pneumonia, otitis media, sepsis and meningitis. Pneumococcal surface protein A (PspA) is a well-characterized virulence factor localized on the surface and a target for vaccine development. In this study, we screened a single-chain antibody variable fragment (scFv) using phage display from a human synthetic library to select a clone 2B11.
View Article and Find Full Text PDFUterine prolapse during pregnancy is an uncommon condition. It can cause preterm labor, spontaneous abortion, fetal demise, maternal urinary complication, maternal sepsis and death. We report the case of uterine prolapse in a 32-year-old healthy primigravid woman.
View Article and Find Full Text PDFRegulator of calcineurin 1 (RCAN1) is located on the Down syndrome critical region (DSCR) locus in human chromosome 21. In this study, we investigated the functional role of RCAN1 in the reactive oxygen species (ROS)-mediated neuronal death signaling. We found that RCAN1 was able to protect the cells from H(2)O(2) -induced cytotoxicity.
View Article and Find Full Text PDFBackground: We report on a case of leakage and migration to the upper abdomen of an unknown injected material that was used for breast augmentation. It was revealed to be prolamin by Fourier transform infrared (FTIR) analysis and pyrolysis gas chromatography/mass spectrometry (PY-GC/MS).
Methods: A 35-year-old woman who had undergone mammary augmentation by transaxillary injection 8 years previously presented with a decreased size of her left breast and a palpable mass in the left upper quadrant (LUQ).