Publications by authors named "Shin Ebara"
Renorrhaphy is often performed after tumor resection during robotic-assisted laparoscopic partial nephrectomy (RAPN). This study aimed to investigate the association between renorrhaphy performance and inflammatory markers. A retrospective cohort study was conducted including patients with renal cell carcinoma who underwent RAPN at eight institutions in Japan between April 2016 and November 2023.
View Article and Find Full Text PDFThis study investigated the effect of mannitol administration on postoperative renal function during robot-assisted partial nephrectomy (RAPN) in patients with renal cell carcinoma (RCC). Patients with RCC who underwent RAPN at eight Japanese facilities between March 2016 and November 2023 were enrolled. In this study, patients were categorized into two groups according to those who received mannitol during RAPN (Group I) and those who did not receive mannitol (Group II).
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- - The study aimed to compare the effectiveness and safety of neoadjuvant chemohormonal therapy (NCHT) versus radical prostatectomy (RP) alone in patients with high-risk prostate cancer undergoing robot-assisted surgery.
- - Data from 1,023 patients were analyzed, with results showing that those who received NCHT had a lower rate of biochemical recurrence (15.8% vs. 29.5%) and better pathology outcomes compared to the RP-only group.
- - The findings indicate that NCHT could be a beneficial pre-surgery treatment for high-risk prostate cancer, improving outcomes without significant safety concerns, although some adverse events were noted.
Article Synopsis
- This study investigates prognostic factors for patients with pathological Grade Group 5 prostate cancer after robot-assisted radical prostatectomy, focusing on a cohort of 217 men from ten Japanese medical centers.
- The research found that the rates of biochemical recurrence-free survival (BCRFS) at 3 and 5 years were 66.1% and 57.7%, respectively, with positive surgical margins (PSMs) and the percentage of positive cancer cores (PPCC) identified as key independent predictors of survival outcomes.
- Ultimately, the study suggests that monitoring PSMs and PPCC could significantly aid in predicting overall survival and disease progression in this high-risk patient group.
Article Synopsis
- The study aimed to examine the occurrence and risk factors for inguinal hernia (IH) following robot-assisted radical prostatectomy (RARP) using data from 3,195 Japanese patients from 2012 to 2021.
- Various surgical techniques were evaluated for IH prevention, but none showed a significant impact on reducing IH development, which affected 243 patients during a median follow-up of 24 months.
- Key risk factors for developing IH included older age, low BMI, and low hospital volume; the findings suggest the need for further research to enhance surgical techniques for IH prevention.
Article Synopsis
- The study explored the link between lymphovascular invasion (LVI) and oncological outcomes in prostate cancer patients who underwent robotic-assisted radical prostatectomy (RARP).
- Out of 3195 patients, 2608 met the criteria, with 11.9% experiencing biochemical recurrence (BCR), showing that LVI adversely affects BCR-free survival and metastasis-free survival in certain patient groups.
- The findings indicate that LVI is a significant independent prognostic factor for recurrence and metastasis, especially in patients with locally advanced disease, highlighting the need for close monitoring in these cases.
: We aimed to examine the relationship between the inflammation-related parameters, such as the neutrophil-to-lymphocyte ratio (NLR), and the pathological findings and biochemical recurrence (BCR) in patients with prostate cancer (PCa) undergoing robot-assisted radical prostatectomy (RARP). : A retrospective multicenter cohort study of patients with PCa who underwent RARP at 10 institutes in Japan was conducted. This study enrolled 3195 patients.
View Article and Find Full Text PDFPurpose: Radiological tumor burden has been reported to be prognostic in many malignancies in the immunotherapy era, yet whether it is prognostic in patients with metastatic urothelial carcinoma (mUC) treated with pembrolizumab remains uninvestigated. We sought to assess the predictive and prognostic value of radiological tumor burden in patients with mUC.
Methods: We performed a retrospective analysis of 308 patients with mUC treated with pembrolizumab.
Background: The impact of unilateral and bilateral nerve-sparing robot-assisted laparoscopic radical prostatectomy (NS-RARP) procedures on continence and the time to continence recovery have not been established.
Material And Methods: We retrospectively reviewed a total of 2801 patients who underwent RARP in 9 institutions. Procedures were classified as NS or non-NS; NS procedures were further classified as unilateral or bilateral.
Background: To investigate the impact of different urinary diversion (UD) techniques on the peri- and postoperative complications of robot-assisted radical cystectomy (RARC) with ileal conduit.
Methods: We retrospectively analyzed 373 patients undergoing RARC with ileal conduit at 11 institutions in Japan between April 2018 and December 2021. Propensity score weighting was performed to adjust for confounding factors such as age, sex, body mass index, performance status, American Society of Anesthesiologists score, previous abdominal surgery, neoadjuvant chemotherapy, and preoperative high T stage (≥ cT3) and high N stage (≥ cN1).
Introduction: Urachus carcinoma is a rare malignancy with an aggressive potential and a poor prognosis, and evidence is limited for its diagnosis and treatment.
Case Presentation: A 75-year-old man underwent fluorodeoxyglucose positron emission tomography/computed tomography for staging prostate cancer, and a mass (standardized uptake value max 9.5) was observed on the outside of the urinary bladder dome.
Article Synopsis
- * Factors like prostate-specific antigen levels, prostate volume, and biopsy results were identified as key predictors in our multivariable analysis.
- * The nomogram showed good predictive ability, correctly diagnosing 39.9% of patients with advanced cancer and helping 91.6% of cases avoid being underdiagnosed.
Article Synopsis
- The study focused on patients with locally advanced prostate cancer (pT3b) undergoing robot-assisted radical prostatectomy (RARP) and evaluated risk factors for biochemical recurrence (BCR) post-surgery.
- Out of 188 patients analyzed, 40.4% experienced BCR within a median follow-up of 32.8 months, with significant rates dropping from 76.4% to 50.8% over three years.
- Key findings highlighted that higher initial prostate-specific antigen levels and positive surgical margins were significant predictors of BCR, suggesting that pT3b patients may benefit from combining therapies to reduce recurrence risks.
Background: This retrospective multicenter cohort study investigated the association of hospital volume with perioperative and oncological outcomes in patients treated with robot-assisted radical prostatectomy (RARP).
Methods: We collected the clinical data of patients who underwent RARP at eight institutions in Japan between September 2012 and August 2021. The patients were divided into two groups based on the treatment site-high- and non-high-volume hospitals.
Article Synopsis
- The study aimed to determine if prostate cancer patients with different locations of positive surgical margins experience varying outcomes after robot-assisted radical prostatectomy.
- Conducted in Japan with 3,195 participants, the research analyzed data from 2,667 patients, contrasting those with negative vs. positive surgical margins over a median follow-up of 25 months.
- Results indicated that patients with multifocal and seminal-vesicle-only positive surgical margins had poorer biochemical recurrence-free survival, while those with apex-only positive margins experienced better outcomes compared to other margin locations.
In this multicenter retrospective cohort study, we aimed to evaluate whether pelvic lymph node dissection (PLND) improved biochemical recurrence (BCR) in patients with prostate cancer (PCa) who underwent robot-assisted radical prostatectomy (RARP) in Japan. A multicenter retrospective cohort study of 3195 PCa patients undergoing RARP at nine institutions in Japan was conducted. Enrolled patients were divided into two groups: those who underwent RARP without PLND (non-PLND group) and those who underwent PLND (PLND group).
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- - A study was conducted on 3195 prostate cancer patients who underwent robot-assisted surgery to create a nomogram for predicting lymph node involvement (LNI).
- - Analyzing data from 1855 patients, the study identified key predictors like prostate-specific antigen levels and biopsy results, yielding a prediction accuracy with an AUC of 84%.
- - The nomogram allows for a cutoff of 6%, enabling 26.5% of patients to avoid unnecessary lymph node removal, with only a minimal risk of missing LNI cases.
We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint.
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- The study aimed to determine if subgroups within the International Society of Urological Pathology Grade Group 4 (GG 4) of prostate cancer patients exhibit different oncological outcomes after robotic-assisted radical prostatectomy (RARP) in Japan.
- A total of 3195 patients were analyzed, with 298 having GG 4 tumors; results showed varied 3-year biochemical recurrence-free survival rates among the subgroups, with the GS 3+5 group having the best outcomes.
- The findings suggest that patients with pathological Gleason scores (GSs) of 4+4 and 5+3 face higher risks of recurrence compared to those with GS 3+5, indicating that the latter may be overestimated in severity among
: This study's objective was to examine patients treated with robot-assisted radical prostatectomy (RARP) for intermediate-risk prostate cancer (IR-PCa), and to identify preoperative risk factors for biochemical recurrence (BCR) in these patients in Japan. : We conducted a retrospective multicenter cohort study of patients with PCa who underwent RARP at 10 institutions in Japan. A total of 3195 patients were enrolled in this study.
View Article and Find Full Text PDFIntroduction: We aimed to examine the relationship between D'Amico intermediate-risk and pathological grade group 1 (pGG1) after robot-assisted radical prostatectomy (RARP).
Patients And Methods: In this retrospective multicenter cohort study, D'Amico intermediate-risk prostate cancer patients who did not receive neoadjuvant therapy, and underwent RARP at 10 institutions in Japan were examined for preoperative factors associated with pGG1.
Results: In total, we enrolled 1161 D'Amico intermediate-risk prostate cancer patients.
Introduction: We evaluated oncological outcomes of patients undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer (PCa) and their perioperative complications in Japan. We investigated clinical and pathological covariates to predict biochemical recurrence (BCR) after RARP.
Methods: A retrospective multicenter cohort study was conducted in RARP patients with PCa at 10 institutions in Japan.
Desmoid tumors are a very rare disease associated with familial adenomatous polyposis, surgical trauma and hormonal factors. Surgical trauma is a critical trigger for sporadic desmoid tumors. Tumor development has been reported, and laparoscopic surgery has become more widely performed than the conventional open surgery.
View Article and Find Full Text PDFThere is no standard second-line or salvage treatment for advanced urothelial carcinoma (UC). Here we investigated the efficacy and safety of gemcitabine, cisplatin, and paclitaxel (GCP) combination chemotherapy as salvage chemotherapy for advanced UC. We retrospectively analyzed the cases of 23 patients with advanced UC who showed progression or recurrence after cisplatin-based chemotherapy.
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- The study aimed to evaluate the effectiveness of neoadjuvant hormonal therapy in improving outcomes for patients with localized prostate cancer undergoing permanent brachytherapy.
- A total of 484 patients were analyzed, revealing that there was no significant difference in 5-year biochemical recurrence-free survival between those who received hormonal therapy and those who did not, regardless of risk group.
- The findings concluded that neoadjuvant hormonal therapy does not enhance oncological outcomes (like progression-free and overall survival) for patients with low- or intermediate-risk prostate cancer treated with this method.