Publications by authors named "Shimura H"

Introduction: Retroperitoneal laparoscopic surgery for benign retroperitoneal tumors is often challenging because of variations in the tumor location and size. In this study, we present a retroperitoneal laparoscopic resection technique used at our institution to treat benign retroperitoneal tumors.

Materials And Methods: This retrospective case series included nine consecutive patients who underwent retroperitoneal laparoscopic tumor resection between 2011 and 2023.

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Brown adipocytes are characterized by a high abundance of mitochondria, allowing them to consume fatty acids for heat production. Increasing the number of brown adipocytes is considered a promising strategy for combating obesity. However, the molecular mechanisms underlying their differentiation remain poorly understood.

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Thyroid ultrasound examinations (TUEs), conducted as part of the Fukushima Health Management Survey (FHMS), were initiated to monitor the health status of residents after the Fukushima Daiichi Nuclear Power Plant accident owing to concerns regarding the increased incidence of thyroid cancer among children, as observed after the Chernobyl Nuclear Power Plant accident. This study reported the clinicopathological characteristics of patients with thyroid cancer diagnosed through the FHMS and treated at the Fukushima Medical University Hospital. Data regarding the clinicopathological characteristics of patients with thyroid cancer were collected and evaluated in this descriptive study.

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  • Researchers conducted a study to explore the connection between thyroid autoantibodies (Tabs) and the clinical profiles of young patients (ages 3-29) with thyroid nodules, using data from 3,018 participants in the Fukushima Health Management Survey.
  • The study discovered that Tabs were found in 13.9% of participants, with higher rates in females, those with diffuse goiter, and those diagnosed with papillary thyroid carcinoma.
  • Findings indicate that Tab positivity is linked to larger thyroid sizes, the presence of diffuse goiter and papillary thyroid carcinoma, and high TSH levels, suggesting that testing for Tabs could enhance assessment methods for thyroid function and cancer detection in younger patients with nodules.
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  • - The study analyzed thyroid cancer detection in children and adolescents in Fukushima after the 2011 nuclear disaster, involving over 253,000 participants with varying levels of radiation exposure.
  • - Utilizing Poisson regression, the research assessed the relationship between external radiation exposure and thyroid cancer, concluding that there was no significant association even at low radiation doses.
  • - The findings indicated that over 99.9% of participants experienced radiation exposure below 5 mSv, with an average follow-up period of 3.7 years, and thus, low radiation exposure was unlikely to increase thyroid cancer risk.
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Introduction: Enfortumab vedotin (EV) is an antibody-drug conjugate combining a monoclonal antibody targeting nectin-4 with a highly potent microtubule disrupting agent. EV is expected to be a candidate for the third-line treatment for urothelial carcinoma previously treated with platinum-based chemotherapy and PD-1/PD-L1 inhibitors. Very few cases of patients experienced hyperglycemia of unknown cause.

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We validated a modified enrichment broth that changes its color when group B Streptococcus (GBS) grows. No GBS was detected in any of the non-yellow samples. Thus, the non-yellow samples were considered GBS-negative without conducting further examinations, potentially reducing medical costs and workload.

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Aims/introduction: Chronic kidney disease (CKD) is a very important issue globally because of the risk of its progressing to end-stage renal disease. We aimed to identify factors contributing to long-term estimated glomerular filtration rate (eGFR) decline to determine an early diagnosis and prevent CKD progression.

Materials And Methods: From January 2003 to December 2006, 5,507 individuals underwent health checkups at our hospital's Preventive Medicine Research Center.

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  • Safinamide is shown to be an effective adjunctive treatment for managing wearing-off symptoms in older patients with Parkinson's disease who are already on levodopa therapy.
  • In a study involving 24 participants (mostly aged 75 and older), significant improvements were observed in various assessments of motor and non-motor symptoms after 18 weeks of treatment.
  • Despite some mild adverse events, the findings indicate that safinamide improves quality of life without introducing new safety concerns.
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Aim: To conduct a post hoc subgroup analysis of patients with type 2 diabetes (T2D) from the RECAP study, who were treated with sodium-glucose cotransporter-2 (SGLT2) inhibitor and glucagon-like peptide 1 receptor agonist (GLP-1RA) combination therapy, focusing only on those patients who had chronic kidney disease (CKD), to examine whether the composite renal outcome differed between those who received SGLT2 inhibitor treatment first and those who received a GLP-1RA first.

Methods: We included 438 patients with CKD (GLP-1RA-first group, n = 223; SGLT2 inhibitor-first group, n = 215) from the 643 T2D patients in the RECAP study. The incidence of the composite renal outcome, defined as progression to macroalbuminuria and/or a ≥50% decrease in estimated glomerular filtration rate (eGFR), was analysed using a propensity score (PS)-matched model.

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Background: Because of the proximity of several ligaments, aponeuroses, and capsule in the limited area of the elbow joint, the precise anatomy is difficult to understand. In the current narrative review, we focused on two anatomical perspectives: the capsular attachment and structures consisting of ligaments.

Methods: Based on the previously performed studies regarding the elbow anatomy, a narrative review was prepared in terms of the capsular attachment and structures consisting of ligaments.

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Introduction: Distant metastasis of T1a renal cell carcinoma is rare and whether metastasis is more probable in patients undergoing hemodialysis remains unclear. We report the autopsy case of a patient undergoing hemodialysis with multiple metastases that rapidly progressed from T1a renal cell carcinoma treated with multimodal therapy including nivolumab.

Case Presentation: A 70-year-old male who underwent hemodialysis was diagnosed with clear cell carcinoma (pT1a, G2) after nephrectomy.

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  • SGLT2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP1Ra) both show protective effects for patients with diabetic kidney disease, often used in combination for type 2 diabetes (T2D).
  • A study involving 643 T2D patients examined differences in annual eGFR decline based on whether patients started with SGLT2i or GLP1Ra.
  • Results indicated that those starting with SGLT2i had a significantly smaller decline in eGFR after adding GLP1Ra, while the reverse pairing showed no significant change, suggesting the preceding drug influences the renal benefits of the combination therapy.
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Lower urinary tract (LUT) function is controlled by the central nervous system, including higher-order cognitive brain regions. The anterior cingulate cortex (ACC) is one of these regions, but the role of its activity in LUT function remains poorly understood. In the present study, we conducted optogenetic experiments to manipulate neural activity in mouse ACC while monitoring bladder pressure to elucidate how the activity of ACC regulates LUT function.

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  • Robot-assisted nephroureterectomy is becoming more common for treating upper tract urothelial carcinoma, but there are concerns about its effectiveness in complicated cases with significant scar tissue.
  • An 86-year-old woman experienced hematuria and was diagnosed with a right renal pelvic tumor one year after undergoing robot-assisted pelvic surgery.
  • This case suggests that despite the presence of dense tissue adhesions from previous surgeries, robot-assisted nephroureterectomy can be safely performed with a successful outcome.
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Context: Examining how overweight/obesity impacts thyroid nodule development in children and adolescents by sex and age can speculate on the mechanism.

Objective: We examined whether overweight in children and adolescents are associated with thyroid nodule development by sex and age.

Design: Approximately 300,000 participants who underwent thyroid ultrasonography in the Fukushima Health Management Survey after a nuclear accident were enrolled.

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The purpose of the present study was to evaluate the in vitro activity of tedizolid against several clinically significant species of Nocardia by comparing with that of linezolid. A total of 286 isolates of Nocardia species, including 236 clinical isolates recovered from patients in Japan and 50 strains (43 species) purchased from NITE Biological Resource Center, were studied. Antimicrobial susceptibility testing was performed using the broth microdilution method.

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  • The primary cause of diffuse thyroid goiter is Hashimoto's thyroiditis, an autoimmune disorder, which is important for children's growth and development.
  • A study analyzed data from over 320,000 participants aged 1-23 to investigate the connections between diffuse goiter, thyroid volume, and body measurements, finding that diffuse goiter is more common in females as they age.
  • Results indicated that higher body mass index (BMI) and the presence of nodules are linked to an increased prevalence of diffuse goiter, particularly reflecting age-related trends in younger populations.
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Purpose: Few clinical studies have compared the operative outcomes between loose- and press-fit stems in radial head arthroplasty (RHA). We aimed to evaluate the radiographic and clinical results of the two radial head implant concepts.

Methods: In this retrospective multicenter study, 32 patients (24 women and 8 men) with a mean age of 63.

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  • Istradefylline (IST) is investigated as an adjunctive treatment for Parkinson's disease (PD) to see if it can reduce the need for higher doses of levodopa, which is commonly linked to motor complications.
  • In a study with 114 PD patients experiencing wearing-off symptoms, those receiving IST required significantly less additional levodopa over 37 weeks compared to those who did not receive IST.
  • Patients treated with IST also showed improvements in motor functions measured by rating scales and wearable devices, suggesting that IST may enhance symptom management without increasing levodopa dosage significantly.
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Immune checkpoint inhibitor (ICI) therapies have broadened the armamentarium for metastatic renal cell carcinoma (mRCC). As the ICI therapy spreads in the clinical settings, immune-related adverse events are more of a concern for clinicians. The present study reports three cases of mRCC treated with pembrolizumab plus axitinib and diagnosed hypopituitarism based on clinical symptoms and hormonal profile.

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Introduction: Epidermoid cysts are tumors and that rarely occur in intrascrotal extratesticular tissues. It is extremely rare for the tumors to penetrate the penile corpora cavernosa.

Case Presentation: We encountered a 4-year-old and a 6-year-old boy with intrascrotal tumors that penetrated the penile corpora cavernosa.

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In potatoes, tuber secondary growth, especially sprouting, deforms the tubers and severely lowers their commercial value. Tuber sprouting is induced by signal substances, such as gibberellin (GA), which are transported to the tuber from the plant body. The molecular mechanism underlying GA-induced sprouting remains ambiguous.

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  • A study evaluated the effects of the order in which patients received sodium-glucose cotransporter inhibitors (SGLT2is) and GLP-1 receptor agonists (GLP1Ras) on kidney health in type 2 diabetes patients.
  • Researchers analyzed data from 643 patients who underwent at least one year of treatment and assessed kidney function based on albuminuria status and glomerular filtration rate (eGFR).
  • The findings indicated no significant difference in kidney outcomes between those who started with SGLT2is vs. GLP1Ras, suggesting that the sequence of medication administration does not impact renal health.
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