Publications by authors named "Shimpei Oba"
Objective: Retinal vein occlusion (RVO) can lead to visual impairment, but the development of collateral vessels can sometimes mitigate significant damage. This study aimed to investigate the relationship between collateral vessels and hypertension, the most common underlying condition associated with RVO, by comparing spontaneously hypertensive rats (SHRs) and wild-type Wister rats (WWRs). We also examined the differences between WWRs and SHRs in terms of sphingosine 1-phosphate receptor 1 (S1PR1) expression and its product nitric oxide synthase 3 (NOS3) expression, which are involved in the formation of collateral vessels after vascular occlusion.
View Article and Find Full Text PDFArticle Synopsis
- A feasibility study was conducted to test the effectiveness of 16S rRNA gene analysis via the MinION sequencer for identifying bacteria in ocular infections.
- The study assessed DNA from various ocular samples, utilizing both 16S rRNA gene sequencing and conventional culture methods for comparison.
- Results showed that the MinION sequencing was quick and accurate, identifying more diverse bacterial species than traditional methods in some cases, enabling faster diagnosis of ocular infections.
Article Synopsis
- * In vivo confocal microscopy (IVCM) revealed significantly reduced nerve fiber density in affected eyes compared to healthy ones, along with increased dendritic cell densities and altered basal cell sizes.
- * The results indicate that neurotrophic keratopathy after surgery might disrupt normal corneal healing and affect immune cell distribution, highlighting the need for more exploration into this condition.
Article Synopsis
- The study aimed to assess whether aqueous and vitreous sampling could effectively identify bacteria in cases of postoperative infectious endophthalmitis using 16S rRNA gene analysis via a nanopore sequencer (MinION™).
- A 55-year-old woman developed severe inflammation in her right eye after cataract surgery, leading to a diagnosis of acute infectious endophthalmitis, prompting surgical intervention where both aqueous and vitreous samples were collected for analysis.
- The results showed that the aqueous humor contained certain bacteria before surgery, while the vitreous sample identified a different organism, suggesting that aqueous sampling could be a viable method for early and predictable identification of the causative bacteria.
Background: It is clinically recognized that collateral vessels can form after retinal vein occlusion (RVO) in some cases and these vessels can lead to spontaneous recovery of the pathological condition. In recent years, optical coherence tomography angiography (OCTA) has become a decisive clinical instrument. Unlike previous angiography tests, OCTA enables the non-invasive visualization of fundus vasculature without the need for administration of a contrast agent.
View Article and Find Full Text PDFObjective: Epilepsy surgery can be successful in children with extensive congenital or early acquired focal or hemispheric brain lesion on magnetic resonance imaging (MRI) despite generalized interictal epileptiform discharges (IEDs). The aim of this study was to assess if rapid eye movement (REM) sleep reduced generalized IEDs and revealed lateralized IEDs to identify the epileptogenic hemisphere in children with generalized IEDs and normal/subtle changes on MRI.
Methods: We studied 20 children with generalized IEDs on scalp electroencephalography (EEG) and normal/subtle changes on MRI who underwent intracranial video-EEG for epilepsy surgery.