Effects of nitrate and nitrite, chemical intermediates of inhaled nitrogen dioxide, on membrane components of red blood cells of rats.

Rat blood was incubated at 37 degrees C for 60 min with either NaNO3 or NaNO2 to examine the relationship between the decrease in the hexose content and Ca2+,Mg2+-ATPase activity of red cell membranes, and NO3- and NO2-. The hexose content decreased depending on the NaNO2 concentration up to 100 microM reaching 76% (p less than 0.05) of the control value.

Plasma inactive renin in patients with diabetes mellitus: effects of standing and the relation to serum protease inhibitor.

In order to investigate the mechanisms of increased plasma inactive renin in diabetics with microvascular complications, changes in active and inactive renin with the progress of diabetes mellitus were studied, and effects of standing on inactive renin release and the relationship between plasma inactive renin and serum trypsin or protease inhibitors wee also studied. Inactive renin increased with the aggravation of diabetes mellitus, but active renin didn't show significant changes with the aggravation of diabetes mellitus. Active renin was significantly increased both in the healthy subjects and in the diabetic patients when they were in an upright position, but no significant change was observed in inactive renin.

Gel filtration profile of plasma active and inactive renin in normals and patients with nephrotic syndrome.

The molecular weight of plasma renin from healthy subjects and patients with nephrotic syndrome, in whom we previously reported that plasma inactive renin was increased, was studied by gel filtration. Activation was performed by acid treatment. The plasma from healthy subjects contains a low molecular weight from of renin (40 000) and a high molecular weight form which can be separated into two peaks of 52 000 and 60 000.

Plasma active and inactive renin in patients with diabetes mellitus.

Plasma active and acid activated inactive renin was measured in healthy subjects and in patients with diabetes mellitus. The angiotensin I generated from the incubation of non-acidified plasma with pig renin substrate was expressed as plasma renin concentration (PRC) and that from acidified plasma was expressed as total renin concentration (TRC). The inactive renin concentration (IRC) was calculated as TRC minus PRC.