[Thrombocytic diseases in generalized myasthenia gravis and their correction by using plasmapheresis and administration of anti- immunoglobulin antisera].

Platelet adhesion and aggregation studies were performed in different test systems in 25 patients with plasmapheresis-treated myasthenia patients. In vivo studies with plasmapheresis and in vitro investigation with anti-immunoglobulin antisera revealed the normalization of the impaired platelet functions.

[Morphological changes in the internal organs in experimental staphylococcal sepsis].

In 200 albino rats pathomorphological changes of different organs were studied during experimental staphylococcal sepsis (from 3 to 45 days of the disease), caused by intramuscular injection of 0.15-0.20 ml suspension of microbes (10(15) per ml) in 10% CaCl2 solution.

[Inhibition of platelet aggregation by dinitrosyl iron complexes with low molecular weight ligands].

The dinitrosyl iron complexes (DNIC) with thiosulphate, cysteine or phosphate were shown to inhibit in vitro (in citrate plasma) the human platelet aggregation induced by ADP, collagen or adrenaline. This effect cannot be explained by the toxic action of DNIC on the platelet membrane, since DNIC-pretreated platelets are capable of aggregating under the action of 10(-8) M/ml of phorbol ester, which is known to cause direct activation of protein kinase C. The antiaggregatory activity of DNIC exceeds that of Na-nitroprusside and seems to be due to nitric oxide capable to activate guanylate cyclase of platelets.

[Experimental staphylococcal sepsis].

Experimental staphylococcal sepsis has been examined in the model suggested by the authors. Staphylococcus aureus culture in a 10% CaCl2 solution was injected intramuscularly to 230 adult albino rats. Fundamental signs of sepsis have been revealed: increased mortality (up to 28% in rats weighing 120-140 g) from day 1 to day 45 after infection, development of local infectious foci, bacteremia, septicemia and septicopyemia.

[Diagnostic role of the determination of the plasma fatty acid spectrum in patients with suppurative surgical infection].

The determination of spectrum of blood plasma fatty acids was performed in patients with purulent surgical infection. The surgical infection was shown to bring about changes in the content of free fatty acids (FFA) in blood plasma. In patients with sepsis undulatory changes in the content of FFA of blood plasma were typical.

[Morphological and cytological characteristics of the burn healing process by various treatment methods].

Morphological and cytological methods were used to study the healing of a burn wound in local isolation wards (an open treatment method) and under ointment bandages (a closed treatment method). Biopsy specimens and imprints from the burn wound surface were taken from 40 patients. During treatment in an abacterial medium, burn wound was rapidly decontaminated, which was a consequence of the appearance in wound exudate of segmented neutrophils with marked neutrophilic granularity.

[Internal topography of the greater duodenal papilla in cholecystitis and pancreatitis].

Comparative examination of the material obtained from 133 cadavers of patients dying after operations for chronic pancreatitis, pancreonecrosis, and cholecystitis as well as dying suddenly with other diseases (control) was carried out. Stereoscopic microscopy was used to study the internal relief of the mucous membrane of the ampulla and ducts of the major duodenal papilla (MDP), and their step-wise histological examination was performed. From 1 to 10 valves were found in 98% of the control cases.

[Changes in the internal organs after hemodilution under hyperbaric oxygenation].

It has been shown in experiments on dogs that following blood replacement with a plasma substitute up to 0.5-2.5 g/100 ml Hb at an oxygen pressure of 3 at.