Publications by authors named "Shimin Wen"

Posterior capsule opacification (PCO) is the most common complication after cataract surgery. Drug-eluting intraocular lens (IOLs) is a promising concept of PCO treatment in modern cataract surgery. However, the large dose of drugs in IOL leads to uncontrollable and unpredictable drug release, which inevitably brings risks of overtreatment and ocular toxicity.

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  • The study aimed to evaluate long-term survival, late side effects, and quality of life in patients with advanced nasopharyngeal carcinoma (NPC) treated with induction chemotherapy and concurrent chemoradiotherapy while modifying radiation therapy volume.
  • Conducted across 6 hospitals in China, the trial included 212 patients randomly assigned to receive chemotherapy before or after concurrent treatment, and both groups underwent radical intensity-modulated radiation therapy (IMRT).
  • Results showed no grade 4 late toxicity, with better 5-year survival rates and improved quality of life indicators in the post-induction chemotherapy group, particularly regarding cognitive function and symptoms like dry mouth and feeling ill.
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Posterior capsular opacification (PCO), the most common complication after cataract surgery, is caused by the proliferation, migration and differentiation of residual lens epithelial cells (LECs) on the surface of the intraocular lens (IOL). Although drug-loaded IOLs have been successfully developed, the PCO prevention efficacy is still limited due to the lack of targeting and low bioavailability. In this investigation, an exosome-functionalized drug-loaded IOL was successfully developed for effective PCO prevention utilizing the homologous targeting and high biocompatibility of exosome.

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Posterior capsular opacification (PCO) is a primary complication after phacoemulsification combined with intraocular lens (IOL) implantation, which is attributed to adhesion, proliferation, and migration of residual lens epithelial cells on IOL. Although surface hydrophilic coating is considered to be a powerful way to inhibit PCO incidence after surgery, it requires complex post-production processes, thus limiting their applicability. In comparison, bulk modification is a stable, effective, and facile IOL synthesis method for PCO prevention.

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Intraocular lens (IOL) is the indispensable implant for cataract surgery. However, posterior capsular opacification (PCO) happens in high incidence after IOL implantation. PCO is caused by adhesion, proliferation, and -differentiation of the residual human lens epithelial cells (HLECs).

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Bacterial keratitis, an ophthalmic emergency, can cause corneal perforation and even endophthalmitis, thus leading to severe visual impairment. To achieve effective treatment of bacterial keratitis, good bioavailability of antimicrobial drugs on the ocular surface is desired. In this investigation, a layer-by-layer (LBL) self-assembly combined with the host-guest recognition was used to construct an antibacterial coating on the surface of corneal contact lens (CLs) to improve drug bioavailability and achieve successful treatment of bacterial keratitis.

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Background: Circular RNAs (circRNAs) play an essential role in developing tumors, but their role in Non- Small Cell Lung Cancer (NSCLC) is unclear. Thus, the present study explored the possible molecular mechanism of circRNAs in NSCLC.

Methods: Three circular RNA (circRNA) microarray datasets were downloaded from the Gene Expression Omnibus (GEO) database.

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The intraocular lens (IOL) is a common, yet important, implantable device used in treatment of cataract in clinics. However, the unexpected adhesion of postoperative residual lens epithelial cells (LECs) often causes serious complications, such as posterior capsular opacification (PCO), which lead to vision loss again. In this investigation, a poly(sulfobetaine methacrylate) (PSBMA) brush coating was fabricated on an IOL to generate a hydrophilic surface coating on the IOL for enhanced cell adhesion resistance so as to decrease PCO incidence.

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Drug-loaded intraocular lenses (IOLs) have received considerable attention in treating complications that arise after cataract surgery, especially posterior capsular opacification (PCO). However, for a better therapeutic effect, the drug concentration in IOLs usually needs to be increased. Herein, we developed multilayer (doxorubicin (DOX)@polyaminoamide (PAMAM) (D@P)/heparin sodium (HEP))5 modified IOLs, which efficiently enhance the inhibitory effect on PCO using the enhanced autophagy effect of a cationic PAMAM.

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Posterior capsule opacification (PCO) is one of the most frequent complications in cataract surgery and likely to cause the second loss of vision. Proliferation and migration of postoperative remnants of lens epithelial cells (LECs) on the implanted intraocular lens (IOL) are the leading causes of PCO. Antiproliferative drugs can be an effective solution but also possess some problems including sudden release and accompanying adverse effects to surrounding normal tissues, which greatly limit the clinical trials.

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The human eye is a sophisticated and sensitive sensory organ. Because of the existence of the blood-ocular barrier and corneal-scleral barrier, safe and efficient ocular drug delivery system is highly desired; yet, it remains an unsolved issue. Due to the unique structure and drug loading property, Poly(amidoamine) (PAMAM) has received much attention in the ocular drug delivery investigation.

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Antiangiogenic therapy, as a new anticancer method, can improve the anticancer effect of traditional therapies. Different antiangiogenic drugs may have different vascular normalization time windows. Whether the antiangiogenic treatment is within the vascular normalization time window is very important in the treatment of cancers.

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  • A meta-analysis was conducted to compare the effectiveness of intensity-modulated radiotherapy (IMRT) versus three-dimensional conformal radiotherapy (3DCRT) in treating non-small cell lung cancer (NSCLC).
  • The study included 10 retrospective studies, evaluating overall survival (OS) and the risk of radiation-related side effects, specifically pneumonitis and esophagitis, with a focus on patient outcomes.
  • The results showed that while IMRT and 3DCRT had similar overall survival rates, IMRT significantly reduced the risk of grade 2 radiation pneumonitis but increased the risk of grade 3 radiation esophagitis.
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  • A systematic review and meta-analysis was conducted to evaluate the effectiveness of gemcitabine and pemetrexed as maintenance treatments for non-small-cell lung carcinoma (NSCLC), focusing on recent studies.
  • The analysis involved searching multiple databases and included data from eleven randomized controlled trials, assessing progression-free survival (PFS) and overall survival (OS) of the treatments against best supportive care (BSC) or placebo.
  • Results showed that gemcitabine and pemetrexed significantly improved PFS compared to BSC, with pemetrexed also enhancing OS, while the combination with bevacizumab had some positive effects, but overall evidence quality varied from moderate to high.
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The aim of this study was to evaluate the efficacy and safety of the combination of docetaxel (TXT) plus tamoxifen (TAM) in advanced non-small-cell lung cancer (NSCLC) patients who had received platinum-based first-line chemotherapy. A total of 120 advanced NSCLC patients pretreated with platinum-based chemotherapy were randomized into two treatment groups (the TXT and TXT+TAM groups) in a 1 : 1 ratio. Reversal of P-glycoprotein (P-gp) expression, tumor response, progression-free survival, overall survival, and safety were evaluated on an intention-to-treat basis.

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Desmoplastic small round cell tumors (DSRCTs) are extremely rare and mainly affect adolescents and young adults. The tumors are usually involved with the abdominal area and/or the pelvic peritoneum. Only a small number of cases have been reported concerning DSRCTs of the testicular region.

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Background: It has been proven that metastasis-associated in colon cancer 1 (MACC1) is a new gene that is related to the invasion and metastasis of tumors. MACC1 also regulates c-met expression. The aim of this study is to explore the expressions of MACC1 and hepatocyte growth factor receptor (c-met), and its relationship with invasion, metastasis, and prognosis of non-small cell lung cancer (NSCLC).

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Background And Objective: Excision repair cross-complementing 1 (Excision-Repair Cross-Complementing 1, ERCC1), an important member of the DNA repair gene family, plays a key role in nucleotide excision repair and apoptosis of tumor cells. Protein kinase C-alpha (Protein kinase C, PKCalpha), an isozyme in protein kinase C family, is an important signaling molecule in signal transduction pathways of tumors, which has been implicated in malignant transformation and proliferation. The aim of this study was to explore the clinical significance of ERCC1 and PKCalpha in non-small cell lung cancer (NSCLC).

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Synopsis of recent research by authors named "Shimin Wen"

  • - Shimin Wen's recent research focuses primarily on innovative approaches to prevent posterior capsule opacification (PCO) following cataract surgery, employing novel drug delivery systems such as drug-eluting intraocular lenses (IOLs) and functionalized materials to enhance therapeutic efficacy and biosafety.
  • - The studies demonstrate successful applications of various coatings and modifications, including NIR-triggered thermosensitive polymers and exosome-based drug delivery systems, which significantly improve the controlled release of drugs and targeting capabilities for effective treatment of PCO.
  • - In addition to ocular applications, Shimin Wen's work also encompasses broader oncological research, including investigations into the role of circular RNAs in non-small cell lung cancer, emphasizing the integration of bioinformatics in understanding cancer mechanisms.