Publications by authors named "Shimin Ren"
-methyl-d-aspartate receptors (NMDARs), key excitatory ion channels, have gained attention as anti-depression targets. NMDARs consist of two GluN1 and two GluN2 subunits (2A-2D), which determine their pharmacological properties. Few compounds selectively targeting GluN2 subunits with antidepressant effects have been identified.
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- - Cannabidiol (CBD), a non-psychoactive compound from cannabis, shows potential in treating various central nervous system disorders like epilepsy and chronic pain, but its exact pharmacological mechanisms remain unclear.
- - This study identified the transient receptor potential canonical 4 (TRPC4) channel as a new target for CBD, demonstrating that CBD can inhibit TRPC4, affecting neuronal excitability in the medial prefrontal cortex.
- - Using whole-cell electrophysiology, researchers found that CBD inhibits the TRPC4 channel's activity, particularly in response to epinephrine, suggesting CBD may reduce neuron excitability by acting on TRPC4 channels.