Publications by authors named "Shimin Hu"
The synchronous presentation of chronic myeloid leukemia (CML) and multiple myeloma (MM) is extremely rare. CML is a myeloproliferative neoplasm originating from an abnormal pluripotent hematopoietic stem cell. It is associated with the - fusion gene located on the Philadelphia chromosome.
View Article and Find Full Text PDFfusion is mostly derived from a reciprocal translocation t(9;22)(q34.1;q11.2) and is rarely caused by insertion.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effects of discontinuing ponatinib, a third-generation TKI, in patients with chronic myeloid leukemia in chronic phase (CML-CP), focusing on treatment-free remission outcomes.
- Researchers reviewed data from 361 patients who attempted stopping TKIs and identified 11 who discontinued ponatinib specifically, with a median follow-up of 60.3 months.
- Results showed that around 53% of patients maintained a state of no relapse (MRFS) for 60 months after stopping ponatinib, particularly those who had sustained MR4.5 for over 2 years before discontinuation.
A Feature Fusion Model Based on Temporal Convolutional Network for Automatic Sleep Staging Using Single-Channel EEG.
IEEE J Biomed Health Inform
November 2024
Article Synopsis
- - The study introduces a new deep learning algorithm called feature fusion temporal convolutional network (FFTCN) designed to automate sleep staging using single-channel EEG data, addressing the time-consuming and subjective nature of traditional methods.
- - FFTCN combines a 1D CNN for extracting temporal features and a 2D CNN for time-frequency features from spectrograms, which are then fused and classified using a temporal convolutional network (TCN).
- - The proposed algorithm shows improved accuracy in classifying sleep stages among healthy subjects across multiple datasets, highlighting its potential to streamline professional sleep monitoring and reduce the workload on sleep technicians.
Tuning Vision-Language Models With Multiple Prototypes Clustering.
IEEE Trans Pattern Anal Mach Intell
December 2024
Article Synopsis
- Foundation models have achieved strong results in areas like natural language processing and computer vision, but they often require fine-tuning with specific knowledge for expert-level performance.
- The paper introduces a new adapter called lusterAdapter that enhances the tuning process of the CLIP model, focusing on vision-language tasks using few annotated samples while preventing loss of prior knowledge.
- Extensive experiments show that lusterAdapter significantly outperforms the original CLIP and other methods, achieving state-of-the-art performance across multiple classification benchmarks, with notable accuracy improvements.
SN eRF: A Framework for Neural Radiance Fields given Sparse and Noisy Poses.
IEEE Trans Vis Comput Graph
August 2024
Article Synopsis
- - Neural Radiance Fields (NeRFs) are great for creating detailed new images from different angles but need lots of accurate images and positions to work well.
- - The SN eRF framework is designed to improve NeRF's effectiveness by working with fewer images and less precise positions by using multiple background knowledge sources.
- - By matching key points and using a Ray Transformer with depth estimation, SN eRF can optimize NeRF's performance, resulting in high-quality image synthesis for indoor scenes.
Article Synopsis
- Cytogenomic characterization is essential for diagnosing and treating acute myeloid leukemia (AML), and this study evaluated the effectiveness of optical genome mapping (OGM) among 159 AML patients.
- OGM demonstrated over 99% sensitivity in detecting clinically relevant cytogenetic abnormalities, and it revealed additional genetic alterations in nearly half of the patients studied, including new fusion genes and chromosomal rearrangements.
- The findings suggest that OGM could significantly improve AML classification and risk assessment, influencing treatment decisions and trial eligibility, especially by identifying diagnostic information that traditional methods may miss.
Learning Virtual View Selection for 3D Scene Semantic Segmentation.
IEEE Trans Image Process
July 2024
2D-3D joint learning is essential and effective for fundamental 3D vision tasks, such as 3D semantic segmentation, due to the complementary information these two visual modalities contain. Most current 3D scene semantic segmentation methods process 2D images "as they are", i.e.
View Article and Find Full Text PDFArticle Synopsis
- * The leukemic cells exhibited a range of doubling times and specific characteristics such as small to medium size, unique nuclear features, and varied cytoplasmic expressions.
- * Despite some differences, TCL1 family-negative T-PLL shares many morphological and immunophenotypic traits with prototypic T-PLL, notably in their T-cell receptor positivity, which can help in diagnosing this rare condition.
Objectives: We sought to characterize the immunophenotype of acute myeloid leukemia (AML) with CBFB rearrangement and correlate the results with cytogenetic and molecular data.
Methods: Sixty-one cases of AML with CBFB rearrangement were evaluated.
Results: The sample population consisted of 33 men and 28 women, with a median age of 49 years.
Article Synopsis
- * Out of 55 patients, only 16% achieved a significant positive response to treatment, with a median survival of just 14 months and a 5-year survival rate of 19%, varying by disease phase.
- * The findings suggest that despite available treatments, the prognosis for these patients is poor; future strategies might include third-generation therapies and allogeneic stem cell transplantation to improve outcomes.
Optical genome mapping (OGM) is a new DNA-based technology which provides comprehensive examination of the entire genome. We report two patients who presented with splenomegaly and leukocytosis with lymphocytosis including villous lymphocytes. Neither patient had lymphadenopathy.
View Article and Find Full Text PDFThe role of Epstein-Barr virus (EBV) in lymphoma cells of nodular sclerosis classic Hodgkin lymphoma (NScHL) is controversial. Our aim was to explore this and establish a clinically feasible model for risk stratification. We interrogated data from 542 consecutive subjects with NScHL receiving ABVD therapy and demonstrated EBV-infection in their lymphoma cells with EBV-encoded small RNAs (EBERs) hybridization.
View Article and Find Full Text PDFThe Beijing Healthy Aging Cohort Study (BHACS) was established to supplement the limited data of a large representative cohort of older people based on the general population and was designed to evaluate the prevalence, incidence, and natural history of cognitive decline, functional disability, and conventional vascular risk factors. The aim was to determine the evolution of these conditions by estimating the rates and determinants of progression and regression to adverse outcomes, including dementia, cardiovascular events, cancer, and all-cause death. It can therefore provide evidence to help policy makers develop better policies to promote healthy aging in China.
View Article and Find Full Text PDFChronic myeloid leukemia (CML) is characterized by leukocytosis with left-shifted neutrophilia, basophilia, eosinophilia, and variable thrombocytosis. However, extremely rare cases of patients with CML without significant leukocytosis and thrombocytosis (aleukemic phase [ALP] CML, or CML-ALP) have been reported. Due to its rarity and limited awareness, there remains a significant knowledge gap concerning the pathologic diagnosis, disease progression, and optimal patient management and outcomes.
View Article and Find Full Text PDFThe aim of this study was to examine the cytogenetic profiles of plasma cell neoplasms (PCNs) at various disease stages, encompassing 1087 patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), newly diagnosed multiple myeloma (NDMM), and refractory/relapsed multiple myeloma (RRMM). Fluorescence in situ hybridization (FISH) analyses were conducted on highly purified plasma cell samples, revealing that 96% of patients exhibited at least one cytogenetic abnormality. The genomic complexity escalated from MGUS to SMM and further to NDMM and RRMM, largely driven by 1q gain, del(17p), -rearrangement (-R), del(1p), and tetraploidy.
View Article and Find Full Text PDFBackground: Cerebrospinal fluid oligoclonal band (CSF-OCB) is an established biomarker in diagnosing multiple sclerosis (MS), however, there are no nationwide data on CSF-OCB prevalence and its diagnostic performance in Chinese MS patients, especially in the virtue of common standard operation procedure (SOP).
Methods: With a consensus SOP and the same isoelectric focusing system, we conducted a nationwide multi-center study on OCB status in consecutively, and recruited 483 MS patients and 880 non-MS patients, including neuro-inflammatory diseases (NID, n = 595) and non-inflammatory neurological diseases (NIND, n=285). Using a standardized case report form (CRF) to collect the clinical, radiological, immunological, and CSF data, we explored the association of CSF-OCB positivity with patient characters and the diagnostic performance of CSF-OCB in Chinese MS patients.
Sampling Equivariant Self-Attention Networks for Object Detection in Aerial Images.
IEEE Trans Image Process
November 2023
Article Synopsis
- Objects in aerial images vary significantly in scale and orientation, making detection challenging for standard deep learning models.
- The proposed sampling equivariant self-attention networks improve feature extraction by adapting to object transformations through localized self-attention and a transformation embedding module.
- The model outperforms existing methods in sampling equivariance, enhances generalization through a novel normalization technique, and achieves state-of-the-art results on multiple datasets without extra computations or parameters.
Introduction: Whether and when to monitor the amount of anti-factor Xa (aFXa) activity in critically ill patients with complex diseases to prevent venous thromboembolism (VTE) remain unclear. This study is a randomised controlled trial to investigate the effect of aFXa level monitoring on reducing VTE and to establish a new method for accurately preventing VTE in critically ill patients with low-molecular-weight heparin (LMWH).
Methods And Analysis: A randomised controlled trial is planned in two centres with a planned sample size of 858 participants.