Publications by authors named "Shimaa Hamdi Abd Elsadek"
Pumpkin seed oil: unveiling its potential in controlling inflammation and pathogenicity during experimental trichinellosis.
Sara Salah Abdel-Hakeem Sulaiman Mohammed Alnasser Alotaibi Meshal Mahmoud Abdel-Zaher Abdel-Samiee Mohamed Salah Eldin Youssef Shimaa Hamdi Abd Elsadek
BMC Vet Res
September 2024
Article Synopsis
- The study explored the effects of pumpkin seed oil on mice infected with the parasite Trichinella spiralis, focusing on its potential to reduce inflammation and parasite levels.
- Mice were divided into five groups and treated with either pumpkin seed oil, albendazole, or served as controls, revealing that pumpkin seed oil significantly lowered parasite numbers and reduced inflammation in the intestines.
- The results indicate that pumpkin seed oil not only decreases parasite burden but also lowers MMP-9 levels, highlighting its promise as an anti-inflammatory and antiparasitic treatment.
In our pursuit of an alternative drug against Trichinella spiralis, we assessed the effectiveness of nanocurcumin in alleviating pathogenesis, parasitological factors, MMP-9 levels, and its expression in the enteral and parenteral phases of infection. The nanocurcumin particles, with a spherical shape and a size of 100 ± 20 nm, were used in the study. Eighty mice were divided into four groups: the control group, the untreated infected group, the nanocurcumin-treated group, and the albendazole-treated group.
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