Synthesis, Molecular Docking and Cytotoxic Activity Evaluation of Organometallic Thiolated Gold(I) Complexes.

The complex [(PhCHNC)AuCl], , was prepared by the reaction of [(MeS)AuCl], , with an equimolar amount of benzyl isocyanide (PhCHNC) ligand. Through a salt metathesis reaction, the chloride ligand in was replaced by potassium benzothiazole-2-thiolate (Kbt) and potassium benzoimidazole-2-thiolate (Kbi) to afford complexes (PhCHNC)Au(κ-S-bt)], and (PhCHNC)Au(κ-S-bi)], , respectively, which were characterized by NMR spectroscopy. The cytotoxic activities of and were evaluated against three human cancer cell lines, including A549 (lung), SKOV3 (ovary), and MCF-7 (breast).

Cyclometalated platinum(ii) complexes of 2,2'-bipyridine N-oxide containing a 1,1'-bis(diphenylphosphino)ferrocene ligand: structural, computational and electrochemical studies.

The preparation and characterization of new heteronuclear-platinum(ii) complexes containing a 1,1'-bis(diphenylphosphino)ferrocene (dppf) ligand are described. The reaction of the known starting complex [PtMe(κN,C-bipyO-H)(SMe)], A, in which bipyO-H is a cyclometalated rollover 2,2'-bipyridine N-oxide, with the dppf ligand in a 2 : 1 ratio or an equimolar ratio led to the formation of the corresponding binuclear complex [PtMe(κN,C-bipyO-H)(μ-dppf)], 1, or the mononuclear complex [PtMe(κC-bipyO-H)(dppf)], 2, respectively. According to the reaction conditions, the dppf ligand in 1 and 2 behaves as either a bridging or chelating ligand.