Publications by authors named "Shima Mirhoseini"
Article Synopsis
- Programmed cell death protein-1 (PD-1) is found on various immune cells and its inhibition has improved cancer treatment through monoclonal antibodies (mAbs).
- Researchers developed anti-PD-1 nanobodies using a method that involves grafting specific regions from an existing mAb into a smaller nanobody to enhance its effectiveness.
- Site-directed mutagenesis was also employed to create mutations that further increase the binding strength of these nanobodies to PD-1, confirmed through multiple laboratory techniques.
