Publications by authors named "Shilpika Pandey"
Article Synopsis
- PptH is a newly discovered enzyme in Mycobacterium tuberculosis that removes a key modification (4'-phosphopantetheine) from carrier proteins, opposing the action of phosphopantetheinyl transferases.
- It has been shown to act on multiple substrates, including specific proteins in M. tuberculosis and other organisms, and is considered the main Ppt hydrolase in mycobacteria.
- The exact reasons for the enzyme's presence in mycobacteria remain unclear, as it does not play a role in coenzyme A salvage or virulence in mouse models of tuberculosis.
The availability of complete genome sequence of Mycobacterium tuberculosis has provided an important tool to understand the mycobacterial biology with respect to host-pathogen interaction, which is an unmet need of the hour owing to continuous increasing drug resistance. Hypothetical proteins are often an overlooked pool though half the genome encodes for such proteins of unknown function that could potentially play vital roles in mycobacterial biology. In this context, we report the structural and functional characterization of the hypothetical protein Rv3272.
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