Publications by authors named "Shilpashree Saha"
Article Synopsis
- The study explores metabolic changes in aged myoblasts, revealing that they face issues like poor glycolysis and insulin resistance, particularly in both human and mouse models of aging.
- It was found that senescent myoblasts produce excess ammonium through a specific metabolic pathway involving methionine, which can contribute to aging effects.
- By manipulating factors like the NANOG protein or inhibiting a specific enzyme (methionine adenosyltransferase 2A), researchers enhanced muscle regeneration and strength, suggesting that altering methionine metabolism could counteract age-related muscle decline.
Cellular senescence leads to the depletion of myogenic progenitors and decreased regenerative capacity. We show that the small molecule 2,6-disubstituted purine, reversine, can improve some well-known hallmarks of cellular aging in senescent myoblast cells. Reversine reactivated autophagy and insulin signaling pathway via upregulation of Adenosine Monophosphate-activated protein kinase (AMPK) and Akt2, restoring insulin sensitivity and glucose uptake in senescent cells.
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