Publications by authors named "Shilpa Tummala"
Objective: The objective of this study was to quantify the subspecialist workforce involved in the clinical education of Obstetrics and Gynecology (OBGYN) residents and to provide an overview of the subspecialist faculty workforce geographic distribution and demographics.
Methods: This cross-sectional, observational study used public data collected from July 1, 2022, through August 31, 2022. A list of Obstetrics and Gynecology residency programs, their sponsoring institutions/locations, and affiliated locations was compiled from the American Medical Association's Fellowship and Residency Electronic Interactive Database.
Industry payments to physicians exceed millions of dollars. Payments can influence physicians' practices and potentially impact trainees. To examine the magnitude of industry payments to obstetrics and gynecology (OB/GYN) and urology residency directors and department chairs in the United States.
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- Primary central nervous system lymphoma (PCNSL) is a severe type of brain lymphoma with poor outcomes despite aggressive treatment; recent studies have identified key genetic mutations linked to its development, particularly in immunocompetent and Epstein-Barr virus-positive patients.* -
- The research established 12 patient-derived xenograft (PDX) models that retained the essential characteristics of PCNSL, confirming the presence of specific mutations in patient samples and highlighting a common deregulated signaling pathway (RelA/p65-hexokinase 2) that contributes to tumor growth.* -
- These PDX models provide a valuable tool for testing new treatments and understanding the disease's mechanisms, focusing on the hyperactive signaling axis as a potential
Article Synopsis
- Isocitrate dehydrogenase (IDH)-mutant tumors rely heavily on NAD+ for survival, and the study explores how activating sirtuin (SIRT) enzymes, which consume NAD+, can affect these tumors.
- The research tested different methods of SIRT activation in IDH-mutant tumor lines, including gene editing and small molecules, revealing that activating Sirt1 significantly depletes NAD+ and enhances tumor cell death when combined with NAMPT inhibition.
- The results suggest that Sirt1 activation can specifically target IDH-mutant tumors using well-tolerated drugs (SIRT-activating compounds), potentially offering a less toxic treatment alternative compared to traditional chemotherapy.
Purpose: Oligodendroglioma has a relatively favorable prognosis, however, often undergoes malignant progression. We hypothesized that preclinical models of oligodendroglioma could facilitate identification of therapeutic targets in progressive oligodendroglioma. We established multiple oligodendroglioma xenografts to determine if the PI3K/AKT/mTOR signaling pathway drives tumor progression.
View Article and Find Full Text PDFBackground: Isocitrate dehydrogenase (IDH) mutant gliomas are a distinct subtype, reflected in the World Health Organization (WHO) 2016 revised diagnostic criteria. To inform IDH-targeting trial design, we sought to characterize outcomes exclusively within IDH mutant gliomas.
Methods: We retrospectively analyzed 275 IDH mutant glioma patients treated at our institution.
Purpose: With the updated World Health Organization (WHO) 2016 neuropathological diagnostic criteria, radiographic prognostic associations in lower-grade gliomas (LGG, WHO grade II and III) are undergoing re-evaluation.
Methods: We identified 316 LGG patients (151 grade II and 165 grade III) for a combined cohort from three independent databases. We analyzed the preoperative axial FLAIR, axial T2-weighted and post-gadolinium volumetric T1-weighted MR images.
Background: Papillary craniopharyngiomas are characterized by BRAFV600E mutations. Targeted therapy can elicit a dramatic radiographic regression of these tumors. Therefore, prediction of BRAF mutation status before definitive surgery could enable neoadjuvant treatment strategies.
View Article and Find Full Text PDFTERT promoter (TERTp) mutations are found in the majority of World Health Organization (WHO) grade IV adult IDH wild-type glioblastoma (IDH-wt GBM). Here, we characterized the subset of IDH-wt GBMs that do not have TERTp mutations. In a cohort of 121 adult grade IV gliomas, we identified 109 IDH-wt GBMs, after excluding 11 IDH-mutant cases and one H3F3A -mutant case.
View Article and Find Full Text PDFProgressive meningiomas that have failed surgery and radiation have a poor prognosis and no standard therapy. While meningiomas are more common in females overall, progressive meningiomas are enriched in males. We performed a comprehensive molecular characterization of 169 meningiomas from 53 patients with progressive/high-grade tumors, including matched primary and recurrent samples.
View Article and Find Full Text PDFAggressive neurosurgical resection to achieve sustained local control is essential for prolonging survival in patients with lower-grade glioma. However, progression in many of these patients is characterized by local regrowth. Most lower-grade gliomas harbor isocitrate dehydrogenase 1 () or mutations, which sensitize to metabolism-altering agents.
View Article and Find Full Text PDFBackground: Recent studies have reported mutations in the telomerase reverse transcriptase promoter (p) in meningiomas. We sought to determine the frequency, clonality and clinical significance of telomere gene alterations in a cohort of patients with progressive/higher-grade meningiomas.
Methods: We characterized 64 temporally- and regionally-distinct specimens from 26 WHO grade III meningioma patients.