High Polygenic Risk Is Associated with Earlier Trabeculectomy in Patients with Primary Open-Angle Glaucoma.

Purpose: To evaluate the association between a polygenic risk score (PRS) for primary open-angle glaucoma (POAG) and the age at the first trabeculectomy and the need for bilateral trabeculectomy.

Design: Retrospective observational cohort study.

Participants: Nine hundred and three genotyped participants with POAG from the Australian and New Zealand Registry of Advanced Glaucoma.

RNA Sequencing of Lens Capsular Epithelium Implicates Novel Pathways in Pseudoexfoliation Syndrome.

Purpose: Pseudoexfoliation syndrome (PEX) is a common systemic disease that results in severe and often irreversible vision loss. Despite considerable research effort, PEX remains incompletely understood. This study sought to perform the first RNAseq study in elucidate the pathophysiology of PEX, and contribute a publicly available transcriptomic data resource for future research.

Complications of Limbal Stay Sutures in Strabismus Surgery.

: The use of limbal stay sutures is a well-established and frequently used technique to assist in intraoperative globe manipulation. As they are removed at the termination of the surgical procedure, they are presumed to be innocuous and not associated with significant postoperative complications.: We describe two cases presenting to the same tertiary care center for the management of their complications post strabismus surgery, the causative factor in both cases being the stay sutures used during the surgical procedure.

Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma.

Importance: Early diagnosis of open-angle glaucoma can lead to vision-saving treatment, and genetic variation is an increasingly powerful indicator in disease risk stratification.

Objective: To compare polygenic and monogenic variants in risk of glaucoma.

Design, Setting, And Participants: Clinical and genetic data were obtained for 2507 individuals from the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) and 411 337 individuals in cross-sectional cohort studies including individuals of European ancestry in the UK Biobank.

Microcornea and bilateral ectopia lentis in an infant: unusual severe ocular presentation of neonatal Marfan syndrome.

We present an unusual case of microcornea, bilateral spontaneous dislocation of lenses, and anomalous optic disks in a 7-week-old girl in whom a systemic diagnosis of Marfan syndrome had not yet been confirmed at presentation. The causes and differential diagnoses of this condition are discussed, and the literature on ocular manifestations of neonatal Marfan syndrome is reviewed.

Comparison of optic disk features in preterm and term infants.

Purpose: To compare the optic disk features of preterm and term infants.

Methods: Digital fundus images of preterm infants were compared with those of infants born at term, imaged within 1 week of birth. The optic disk horizontal diameter to vertical diameter ratio, the disk-macula to disk-diameter ratio, and the presence or absence of double ring sign was noted.

Ocular myiasis in a glioma: a case report.

Background: Ocular myiasis though rare, is usually found in association with basal cell carcinoma. It is rarer still in tumors other than basal cell carcinoma. We report a case of ocular myiasis in a glioma which is hitherto unreported to the best of our knowledge.

A rare variant of ankyloblepharon filiforme adnatum associated with skin hypopigmentation: A case report from South India.

We report ankyloblepharon filiforme adnatum (AFA) along with associated skin lesions in a 7-day-old child from South India. It could be a variant of the well described ankyloblepharon-ectodermal defects-cleft lip and palate syndrome also called Hay-Wells syndrome wherein AFA, skin lesions, and clefting are characteristic. The ocular features, genetic inheritance, and possible systemic associations, along with the options for management, are discussed.

Incidence and risk factor evaluation of exposure keratopathy in critically ill patients: a cohort study.

Purpose: Recent emphasis on eye care in intensive care unit (ICU) patients has translated to eye assessment being part of routine care. In this setting, we determined the incidence, risk factors, and resolution time of exposure keratopathy.

Methods: In this prospective cohort study, 301 patients were examined within 24 hours of ICU admission and subsequently daily by an ophthalmologist till death or discharge.