Immunization with a Double-Mutant (R192G/L211A) of the Heat-Labile Enterotoxin of Escherichia coli Offers Partial Protection against Campylobacter jejuni in an Adult Mouse Intestinal Colonization Model.

We have previously shown that antibodies to cholera toxin (CT) reacted with the major outer membrane proteins (MOMPs) from Campylobacter jejuni strains on Western blot. Further, oral immunization with CT significantly protected against challenge with C. jejuni in an adult mouse colonization model of infection.

Oral immunization with cholera toxin provides protection against Campylobacter jejuni in an adult mouse intestinal colonization model.

Unlabelled: Immunity to Campylobacter jejuni, a major diarrheal pathogen, is largely Penner serotype specific. For broad protection, a vaccine should be based on a common antigen(s) present in all strains. In our previous study (M.

Tetracycline resistance is frequent among Campylobacter jejuni isolates from Kuwait.

Campylobacter jejuni is a major cause of diarrhea worldwide, including Kuwait. Kuwait is an important destination for commerce, employment for expatriates, and stationing of multinational troops. Knowledge about antimicrobial susceptibility of C.

Major outer membrane proteins from many Campylobacter species cross-react with cholera toxin.

We have previously shown that Campylobacter jejuni strains do not produce a functional cholera toxin-like toxin (CTLT) detectable in a Chinese hamster ovary cell assay. Instead, the 53-kDa major outer membrane protein (OMP) of C. jejuni, PorA, reacts with cholera toxin (CT) antibody on immunoblots.

Identification of a Campylobacter jejuni protein that cross-reacts with cholera toxin.

The question of whether Campylobacter jejuni produces a cholera toxin-like toxin (CTLT) has been controversial. The objective of this study was to identify the factor that cross-reacts with CT from C. jejuni.

Ciprofloxacin resistance and its molecular mechanism in Campylobacter spp. isolated in Kuwait.

Campylobacter spp. are an important cause of diarrhea in Kuwait. Because susceptibility data for ciprofloxacin and erythromycin, the two recommended drugs for treatment, are not available for this part of the world, 64 Campylobacter spp.

PorA protein of Campylobacter jejuni is not a cytotoxin mediating inflammatory diarrhoea.

Campylobacter jejuni is a major food-borne pathogen and a leading cause of diarrhoea. A cytotoxin is most likely involved in the pathogenesis of inflammatory diarrhoea due to C. jejuni.