Publications by authors named "Shilpa A Gaidhane"

Article Synopsis
  • Pirfenidone is a key antifibrotic medication primarily used for treating idiopathic pulmonary fibrosis (IPF) by interfering with pathways that contribute to fibrosis and reducing inflammation and oxidative stress.
  • Clinical trials show it effectively slows lung function decline and improves survival in IPF patients and is being explored for use in other fibrotic diseases like liver and kidney fibrosis.
  • While it has significant benefits, pirfenidone can cause side effects such as gastrointestinal issues and photosensitivity, requiring careful monitoring, and future research is looking into combination therapies and further applications in managing fibrotic conditions.
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A rare brain vasculature illness called dolichoectasia (DE) causes the blood vessels to enlarge and elongate. DE describes an irregular enlargement and dilatation of arteries; this condition primarily affects big blood vessels such as the internal carotid and vertebrobasilar arteries. A range of neurological symptoms may result from this illness because of the compression of nearby structures or changed hemodynamics.

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Coccidioidomycosis and histoplasmosis are endemic mycoses caused by the species and , respectively. While these fungal infections are often associated with immunocompromised individuals, they pose significant risks to immunocompetent hosts. This review comprehensively analyzes these infections in immunocompetent individuals, focusing on clinical features, diagnostic approaches, and management strategies.

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  • A 25-year-old woman with immune thrombocytopenic purpura (ITP) presented with a spontaneous petechial rash, abdominal pain, and dizziness, indicating severe thrombocytopenia.
  • Imaging revealed free fluid in the peritoneal cavity and a ruptured ovarian cyst, leading to significant internal bleeding.
  • The patient was treated conservatively with platelet transfusions, steroids, and romiplostim to manage her severe bleeding and ITP relapse.
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  • * It presents a case of a 13-year-old girl with symptoms like headache and nausea, where imaging showed a solid lesion causing obstructive hydrocephalus.
  • * The report emphasizes the importance of advanced imaging techniques for early detection and the need for prompt treatment to improve outcomes for young patients with these types of tumors.
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In young patients, ischemic stroke is an uncommon result of vertebral artery dissection (VAD). Damage to the vertebrae can occur suddenly or as a result of trauma. There are no generally recognized recommendations for diagnosis and treatment, and the majority of vague symptoms and delayed presentation provide a significant diagnostic problem.

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An unusual anatomical variation known as "beaver tail liver" occurs when the liver's left lobe spreads laterally until it touches the spleen. It is also known as a sliver liver, saber-shaped liver, or flax-like liver. We are talking about a 34-year-old man, a chronic alcoholic in this case, who had complaints of upper abdominal pain, persistent vomiting, and abdominal palpation elicited tenderness in the upper abdomen.

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Complications of acute-on-chronic liver failure (ACLF) include increased short-term mortality. Extrahepatic organ failures result from chronic liver disease and acute hepatic injury. This combination characterizes end-stage liver disease.

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder known for its intricate clinical manifestations, spanning a spectrum of symptoms, including neuropsychiatric SLE (NPSLE) and lupus nephritis (LN). This condition predominantly affects young women of childbearing age, presenting a diverse array of symptoms that pose challenges in both diagnosis and treatment. Diagnosing central nervous system (CNS) involvement in SLE remains notably difficult despite being rooted in an autoimmune inflammatory response driven by cytokine surges.

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  • Dermatomyositis is a rare inflammatory muscle disease that causes inflammation in muscles and related tissues, with an unknown cause.
  • Diagnosis is based on clinical signs like skin rashes, muscle weakness, elevated enzyme levels, and results from electromyograms and muscle biopsies.
  • The case study discusses a fatal instance of dermatomyositis in a 23-year-old woman who died from complications of the disease, with no indications of cancer.
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This review critically examines enteral feeding strategies in managing acute pancreatitis, focusing on the contrasting early and delayed initiation approaches. Acute pancreatitis, marked by pancreatic inflammation, poses complex challenges, and nutritional interventions are pivotal in patient outcomes. Early enteral feeding, initiated within 24-48 hours, is associated with positive outcomes such as shortened hospital stays and reduced complications.

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Background: The discovery of antimicrobials is a pioneering step in health sciences concerning preventive care and early management for infectious diseases. However, with advancements in health sciences, inappropriate knowledge, practices, and over-the-counter medications were often used by the general population in underdeveloped nations like India without thinking about its consequences which leads to the use of antimicrobials excessively or inadequately, which is also a factor for antimicrobial resistance. This quantitative study determines the awareness of healthcare professionals and laypersons about usage and resistance of antimicrobials.

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An inherited neurodegenerative ailment called Huntington's disease (HD) of gradual physical impairment, cognitive decline, and psychiatric symptoms. It is brought on by a mutation of the HTT gene, which causes aberrant huntingtin protein buildup in neurons. This predominantly affects the striatum and cerebral cortex, where neuronal malfunction and eventual cell death follow.

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A posterior midline cutaneous lesion known as a faun tail nevus or aberrant lumbar hypertrichosis is significant to doctors because it may serve as a cutaneous signal for an underlying spinal cord and spine abnormalities. We describe a 17-year-old child who, since infancy, has had excessive hair development over his lumbosacral area. The lower spinal cord was affected by a related spinal abnormality.

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Introduction Ageing results in the deprivation of various physiological reserves and resources resulting in the development of frailty. Frailty in turn brings various morbidities and dependence on others for the survival of an individual making him weak and vulnerable to various infective and non-infective insults leading to death. The present study assessed frailty in rural older adults of central India by using the Frailty Index in Rural Elderly - Mental Status, Activities of Daily Living, Depression, and Events (FIRE-MADE) and correlated it with sarcopenia assessed by the Asian Working Group for Sarcopenia (AWGS) and European Working Group on Sarcopenia in Older People (EWGSOP2) criteria.

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Aim: The aim of this study is to assess the efficacy of the serum lactate/albumin (L/A) ratio as a prognostic marker of sepsis syndrome.

Materials And Methods: This study was conducted in the Internal Medicine Department at Acharya Vinoba Bhave Rural Hospital with a sample size of 160 cases of sepsis. The serum L/A ratio was calculated on admission and correlated with deaths and morbidity.

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Simultaneous bilateral spontaneous pneumothorax is a situation that rarely occurs. The patient can have various presentations, from dyspnoea and chest pain to significant respiratory failure. Although it causes lung collapse in nearly two thirds of cases, early diagnosis and treatment are of the utmost importance.

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Article Synopsis
  • Electrical injuries from lightning strikes can lead to high rates of morbidity and mortality, with serious complications like pulmonary edema and acute respiratory distress syndrome.
  • A case study is presented of a 62-year-old male who experienced symptoms such as shortness of breath, vomiting, and hoarseness after a lightning strike.
  • Despite receiving treatment including airway protection and supportive care, the patient ultimately succumbed to severe lung contusion.
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We present a case of a 50-year-old female who came to us with chief complaints of breathlessness, general weakness, and cough. She tested positive for coronavirus disease 2019 (COVID-19) on testing with Reverse Transcription Polymerase Chain Reaction (RT-PCR). She had high resolution computed tomography (HRCT) thorax score of 22/25.

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  • Chronic myeloid leukemia (CML) is characterized by an increase in immature granulocytes and is commonly linked to the Philadelphia chromosome, affecting 95% of cases.
  • Some CML patients (3.1-9.1%) may also experience extramedullary proliferation in areas like skin or lymph nodes, leading to conditions like myeloid sarcoma (MS), which is associated with immature myeloid cells.
  • This report discusses an elderly female patient with CML in the chronic phase who presented with myeloid sarcoma in her right parotid gland during treatment with imatinib.
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Acute disseminated encephalomyelitis (ADEM) is a disease of the brain and spinal cord that is an immune-mediated inflammatory and demyelinating disorder, which is commonly preceded by an infection. Some reports have also shown the association of acute demyelination of the central nervous system (CNS) with vaccination. Primarily, the involvement of the white matter of the cerebral hemispheres, brain stem, and spinal cord is observed.

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A woman came to the emergency room with swelling of the face, which included swelling around the lips and the eyes. The patient had undergone root canal treatment under lidocaine anesthesia one day prior, after which she developed swelling. Because angioneurotic edema was a possibility, the complement components C3 and C4 and C1 esterase inhibitor (C1-INH) were tested.

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The novel oral sodium-glucose cotransporter-2 (SGLT2) inhibitor Ertugliflozin (SteglatroTM) is introduced as a monotherapy or in conjunction with another antidiabetic drug regimen for the treatment of type 2 diabetes mellitus (T2DM).Additional safe and efficient treatment options for patients and physicians are of utmost importance as the incidence of T2DM rises. As a standalone therapy or an adjunctive treatment, ertugliflozin seems to be a reliable and safe option.

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The presence of an extra (third) kidney is an unusual congenital anomaly of the urinary system (US), having less than a hundred cases reported globally. Owing to the rare occurrence of this complex anomaly, the fused supernumerary kidney and horseshoe portion is very scarcely reported with unknown incidence. This paper presents a rare renal anomaly case of a fused supernumerary kidney with a horseshoe portion in a 41-year-old male who presented with fever, abdominal pain, and burning micturition.

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