Overexpression of is associated with cisplatin resistance and may depend on mA modification in patients with cervical cancer.

Cervical cancer (CC) is the fourth leading cause of cancer-associated mortalities among women worldwide. The chemotherapeutical platinum-based agent cisplatin (DDP) is the standard therapy for locally advanced or recurrent CC; however, platinum resistance limits its clinical benefit. Therefore, the present study aimed to identify key genes associated with DDP resistance in patients with CC and investigate the underlying molecular mechanisms.

Knockdown of VEGF-B improves HFD-induced insulin resistance by enhancing glucose uptake in vascular endothelial cells via the PI3K/Akt pathway.

Vascular endothelial growth factor B (VEGF-B) has been suggested to play a crucial role in regulating whole-body glucose homeostasis. However, the involved mechanisms are not fully understood. This study aimed to elucidate the regulatory effects and mechanisms of VEGF-B on glucose uptake in skeletal muscle, focusing on glucose uptake by skeletal muscle cells and vascular endothelial cells.

Design strategies and applications of cyanine dyes in phototherapy.

Cyanine dyes have been widely used in phototherapy in recent years due to their excellent optical properties and diverse modifiable structures. This review provides detailed descriptions of the basic structures of various cyanines and their derivatives as well as their optical properties. It summarizes the strategies for constructing cyanine dyes for phototherapy and discusses their structure-effect relationship.

Identification of a rank-based radiomic signature with individualized prognostic value for lung adenocarcinoma in a multi-cohort study.

Objectives: Radiomics provides an opportunity to evaluate cancer prognosis noninvasively. However, the susceptibility of the radiomic quantitative features to multicenter effects, leads to the clinical dilemma of the radiomic signatures. This study aimed to develop a radiomic signature to circumvent multicenter effects, achieving the individualized prognostic assessment of lung adenocarcinoma (LUAD).

Environmentally Friendly, Dual-Responsive Actuator Based on Nafion, Carboxylated Multiwalled Carbon Nanotubes, and Polyethylene.

As a type of smart material, flexible stimulus-responsive actuators have become a hot research topic nowadays. However, flexible actuators responding to a single stimulus source are susceptible to external perturbations, which may lead to an unstable function or even failure. Therefore, in this paper, we proposed a bilayer actuator that can be driven by both humidity and light by combining the humidity-sensitive Nafion, carboxylated multiwalled carbon nanotubes (cMWCNT) with excellent photothermal conversion properties, and commercial polyethylene (PE) tape with good humidity insensitivity and thermal expansion.

αPD-1 immunotherapy promotes IL-17A production and promotes the formation of acute radiation-induced lung injury.

Background: Radiotherapy (RT) is essential in the treatment of thoracic neoplasms. Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) have significantly improved the clinical management of non-small cell lung carcinoma (NSCLC).

Objective: This study aimed to investigate the impact of combining anti-PD-1 (αPD-1) immunotherapy with radiotherapy on lung injury.

A gamified cognitive behavioral therapy for Arabs to reduce symptoms of depression and anxiety: A case study research.

Background: Depression and anxiety are prevalent mental health issues addressed by online cognitive behavioral therapy (CBT) via mobile applications. This study introduces Sokoon, a gamified CBT app tailored for Arabic individuals, focusing on alleviating depression and anxiety symptoms (DASDs).

Objectives: The objectives of this study were to: Evaluate the effectiveness of Sokoon in reducing symptoms of depression and anxiety.

High-Safety Lithium-Ion Battery Separator with Adjustable Temperature Function Inspired by the Sugar Gourd Structure.

As the power core of an electric vehicle, the performance of lithium-ion batteries (LIBs) is directly related to the vehicle quality and driving range. However, the charge-discharge performance and cycling performance are affected by the temperature. Excessive temperature can cause internal short circuits and even lead to safety issues, such as thermal runaway.

Enhancing Electrocatalytic CO-to-CO Conversion by Weakening CO Binding through Nitrogen Integration in the Metallic Fe Catalyst.

Metallic iron (Fe) typically demonstrates the unfavorable catalytic activity for the CO reduction reaction (CORR), mainly attributed to the excessively strong binding of CO products on Fe sites. Toward this end, we employed an effective approach involving electronic structure modulation through nitrogen (N) integration to enhance the performance of the CORR. Here, an efficient catalyst has been developed, composed of N-doped metallic iron (Fe) nanoparticles encapsulated in a porous N-doped carbon framework.

Stochastic processes shape the functional and phylogenetic structure of bird assemblages at the mine area in southwest China.

Understanding the mechanisms of community assembly is a key question in ecology. Metal pollution may result in significant changes in bird community structure and diversity, with implications for ecosystem processes and function. However, the relative importance of these processes in shaping the bird community at the polluted area is still not clear.

Alpiniae oxyphyllae fructus improves production performance and egg quality of laying breeder hens by regulating reproductive hormones, antioxidant function, immunity and intestinal health.

Alpiniae oxyphylla fructus was extensively utilized both as dietary supplements and traditional herbal medicines for healthcare functions and has exhibited a positive impact on animal health. The present study aimed to investigate the effects of Alpiniae oxyphyllae fructus powder (AOP) on production performance, egg quality, egg yolk fatty acid composition, reproductive hormones, antioxidant capacity, immunity, anti-apoptosis ability, and intestinal health in hens. A total of 252 Hainan Wenchang laying hens (30-wk-old) were randomly divided into 3 groups with 6 replicates, a basic diet with 0 (CON), 1 g/kg AOP (AOP1), and 3 g/kg (AOP3) mixed AOP.

CD3ε of a pan T cell marker involved in mouse keratitis.

Aim: To explore whether CD3ε is involved in the adaptive immunity of () keratitis in mice and the role of innate and adaptive immunity in it.

Methods: Mice models of keratitis were established by intra-stromal injection and corneal epithelial scratching. Subconjunctival injections of natamycin, wedelolactone, LOX-1 inhibitor (poly I) or Dectin-1 inhibitor (laminarin) were used to treat mice with keratitis.

Self-Assembly of Binderless MXene Aerogel for Multiple-Scenario and Responsive Phase Change Composites with Ultrahigh Thermal Energy Storage Density and Exceptional Electromagnetic Interference Shielding.

The severe dependence of traditional phase change materials (PCMs) on the temperature-response and lattice deficiencies in versatility cannot satisfy demand for using such materials in complex application scenarios. Here, we introduced metal ions to induce the self-assembly of MXene nanosheets and achieve their ordered arrangement by combining suction filtration and rapid freezing. Subsequently, a series of MXene/ K/paraffin wax (PW) phase change composites (PCCs) were obtained via vacuum impregnation in molten PW.

DN-DETR: Accelerate DETR Training by Introducing Query DeNoising.

We present in this paper a novel denoising training method to speed up DETR (DEtection TRansformer) training and offer a deepened understanding of the slow convergence issue of DETR-like methods. We show that the slow convergence results from the instability of bipartite graph matching which causes inconsistent optimization goals in early training stages. To address this issue, except for the Hungarian loss, our method additionally feeds GT bounding boxes with noises into the Transformer decoder and trains the model to reconstruct the original boxes, which effectively reduces the bipartite graph matching difficulty and leads to faster convergence.

A study on different types of moral courage and coping styles of clinical nurses: based on potential profile analysis.

Background: In professional ethics-related events, there are various unpleasant and complex ethical issues that require strong moral courage. Our aim is to identify and describe the potential categories of moral courage among nurses and to clarify the coping styles of nurses under different categories.

Method: A cross-sectional study was conducted using three data collection tools: a self-designed general information questionnaire, a Chinese version of the Moral Courage Scale, and a Trait Coping Style Questionnaire.

A Unified Interactive Model Evaluation for Classification, Object Detection, and Instance Segmentation in Computer Vision.

Existing model evaluation tools mainly focus on evaluating classification models, leaving a gap in evaluating more complex models, such as object detection. In this paper, we develop an open-source visual analysis tool, Uni-Evaluator, to support a unified model evaluation for classification, object detection, and instance segmentation in computer vision. The key idea behind our method is to formulate both discrete and continuous predictions in different tasks as unified probability distributions.

Spatial-spectral mapping to prepare frequency entangled qudits.

Entangled qudits, the high-dimensional entangled states, play an important role in the study of quantum information. How to prepare entangled qudits in an efficient and easy-to-operate manner is still a challenge in quantum technology. Here, we demonstrate a method to engineer frequency entangled qudits in a spontaneous parametric downconversion process.

Observation of Anomalous Orbital Angular Momentum Transfer in Parametric Nonlinearity.

Orbital angular momentum (OAM) conservation plays an important role in shaping and controlling structured light with nonlinear optics. The OAM of a beam originating from three-wave mixing should be the sum or difference of the other two inputs because no light-matter OAM exchange occurs in parametric nonlinear interactions. Here, we report anomalous OAM transfer in parametric upconversion, in which a Hermite-Gauss mode signal interacts with a specially engineered pump capable of astigmatic transformation, resulting in Laguerre-Gaussian mode sum-frequency generation (SFG).

Comparison of gut microbiota between immigrant and native populations of the Silver-eared Mesia () living in mining area.

The complex gut bacterial communities have a major impact on organismal health. However, knowledge of the effects of habitat change on the gut microbiota of wild birds is limited. In this study, we characterized the gut microbiota of two different subspecies of the Silver-eared Mesia (), the native subspecies () and immigrant subspecies (), using 16S rRNA gene high-throughput sequencing.

Tourniquet application in primary total knee arthroplasty for osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.

Objective: The aim of this study was to identify the influence of a tourniquet on the blood loss, transfusion requirement, swelling, pain, knee function, range of motion (ROM), operation time, bone cement mantle thickness, and complications in patients operated with total knee arthroplasty (TKA).

Methods: Two authors independently retrieved PubMed, Embase, and CENTRAL to identify eligible randomized controlled trials (RCTs) evaluating the effectiveness of a tourniquet in TKA. Fixed- ( < 50%) or random-effects ( > 50%) models were selected to perform meta-analysis according to the value of .

Metal and metalloid sources apportionment in soil of two major agroecosystems of southern China.

Apportioning the sources of metals/metalloids is a critical step toward soil quality protection and ecological restoration. The objective of this study was to identify the potential sources of contamination of As, Cd, Cr, Cu, Hg, Mn, Pb, and Zn, and determine the contribution rates of each source, to rice and sugarcane agroecosystems of southwestern Guangxi, southern China. We collected a total of 300 soil samples at a former lead-zinc mine and at two reference sites, 6 and 60 km away from the mine, sampling both agroecosystems at each site.

Experimental realisations of the fractional Schrödinger equation in the temporal domain.

The fractional Schrödinger equation (FSE)-a natural extension of the standard Schrödinger equation-is the basis of fractional quantum mechanics. It can be obtained by replacing the kinetic-energy operator with a fractional derivative. Here, we report the experimental realisation of an optical FSE for femtosecond laser pulses in the temporal domain.

Dual/Triple Template-Induced Evolved Emulsion for Controllable Construction of Anisotropic Carbon Nanoparticles from Concave to Convex.

Anisotropic mesoporous carbon (AMC) nanoparticles with asymmetric external morphologies, topological internal structure, and superior performance of carbon species are attracting great attention because of their seductive features differentiating them from symmetric nanoparticles. However, a bewildering challenge but crucial desire remains to endow them with flexibly tunable morphology and pore structure. Herein, a dual/triple-templating evolved emulsion strategy for tunable fabrication of AMC nanoparticles with distinctive defined structure by interface-energy-induced self-assembly is first reported based on a brand-new mechanism.