Publications by authors named "Shilin Gao"

Accumulating evidence has reported that the intestinal microbiota could play important roles in the occurrence and progression of severe trauma. However, the hypothesized potential targeted intestinal microbiota to mediate and regulate the levels of inflammatory cytokines and promote rapid recovery of body after severe trauma remains unclear. This study was aimed to explore the changes and correlation of intestinal microbiota and inflammatory cytokines in rats with severe crush and fracture trauma.

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Background: This study was designed to characterize gut microbiota changes of the patients with gastric cancer before and after the gastrectomy during their hospital staying periods.

Methods: 16S ribosomal RNA (rRNA) gene sequencing was used to evaluate differences in gut microbiota among patients with gastric cancer before and after the gastrectomy by comparing gut microbiota α diversity, β diversity, and structure composition at different taxonomic levels.

Results: A total of 120 fecal specimens were collected from 60 patients.

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Sudden groundwater pollution in karst areas poses a serious threat to drinking water safety. Tracing contamination sources is crucial for managing and remediating groundwater pollution. Traditional tracing methods often lack accuracy, so this study combined multiple techniques to trace and quantify pollution sources near the municipal solid waste (MSW) landfill in Zunyi City, Guizhou Province, China.

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Groundwater in karst regions is a vital drinking water source, but it is highly susceptible to contamination from industrial activities, which exacerbate pollution and pose health risks. This study investigated the concentration, spatial distribution, quality, health risks and sources of trace elements (TEs) in groundwater within a newly established industrial park in Guiyang, a representative city with a karst landscape. The results indicated that the trace element concentrations followed the order: Ti > Fe > Al > Ni > Cr > Mn > V > Cu > As > Co.

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Sewage systems are a major source for microplastics in riverine exports to oceans. Urban areas are generally considered hotspots for microplastic discharge, whereas emissions from rural areas remain largely understudied. Hence, this study investigated the abundance, characteristics, and polymer types of microplastics in rural wastewater treatment plants (WWTPs) in Guiyang and estimated the annual microplastic emissions of China based on sewage discharge.

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Article Synopsis
  • The study highlights the increasing understanding of dissolved trace element (DTE) pollution's environmental impact, particularly in the vulnerable southeastern edge of the Qinghai-Tibet Plateau, focusing on the Lancang River (LCR).
  • It analyzes 25 surface water samples from the LCR’s upstream area to identify the sources and health risks of seven trace elements, revealing that while most elements stem from natural processes, manganese is primarily linked to human activities like industrial construction.
  • Overall, the DTE concentrations are within safe limits according to international drinking water standards, indicating good water quality, though ingestion poses a slight non-carcinogenic health risk, especially for children.
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Objectives: Dysphagia is a common complication in stroke patients, widely affecting recovery and quality of life after stroke. The objective of this systematic review is to identify the gaps that between evidence and practice by critically assessing the quality of clinical practice guidelines (CPGs) for management of dysphagia in stroke.

Methods: We systematically searched academic databases and guideline repositories between January 1, 2014, and August 1, 2023.

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The rivers have been proven to be potential sources and the major transport pathways of microplastic (MP) in natural aquatic eco-systems, yet there is an absence of understanding the provenances and distribution dynamics of MP in fluvial water body of urban regions. The present investigation aimed to characterize the distribution and accumulation of MPs in both surface water and riverine bed sediments in a typical urban river (Nanming River, southwest China), during the dry and wet seasons of 2021. MP were detected throughout the entire sample set, with average surface water abundances of 750 ± 53 n/m and 693.

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Objectives: We conducted this study to assess the application effect of the family doctor contract service mode of 'basic package+personalised package' in the management of hypertension patients.

Design: Observational study.

Setting: The study was conducted at a community health centre in Southwest China.

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Effective management of pollutants in urban environments is crucial for achieving sustainable cities. Microplastics, as an emerging pollutant widely present in contemporary environments, have received widespread attention in recent years. However, limited studies have reported the impact of rapid urbanization on regional microplastics.

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Microplastic pollution threatens water systems worldwide. As one of the most important parts of city wastewater treatment, wastewater treatment plants are not only microplastics interception barriers but also emission sources. Water samples were collected from each sewage treatment plant stage and sludge from the sludge dewatering room.

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The tanglesome allocation of landscape types at various spatial dimensions is an important component influencing the quality of groundwater environment in karst cities. Trace elements can be used as indicators of the extent of impact on groundwater which is an effective means of tracing groundwater contamination. In this study, we studied the influence of landscape patterns on trace elements in groundwater of typical karst cities in Southwest China (Guiyang City) on a multi-spatial scale by using multivariate statistical analysis.

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Hydrogeochemical processes of trace elements (TEs) are of considerable significance to river water and groundwater resource assessment and utilization in the karst region. Therefore, seven TEs were analyzed to investigate their contents, spatial variations, sources, and controlling factors in Guiyang, a typical karst urban area in southwest China. The results showed that the average content of TEs in river water (e.

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Anthropogenic activities associated with various new technologies are increasingly disrupting the geochemical cycles of rare earth elements (REEs). For example, samarium (Sm) and gadolinium (Gd) have emerged as microcontaminants in the natural waters of developed areas. Surface water samples of 13 urban lakes were collected in Wuhan, the largest city in central China, with a population of over 11 million.

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Urban rivers are suffering from a significant anthropogenic impact. In this study, eight trace metals were investigated in surface water along the Yangtze River in Chongqing, China. The decreasing trend of trace metals was observed in water as Sr > Li > Mo > As > Cu > Ni > Cr > Co.

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Circular RNAs (circRNAs) have been reported to play crucial roles in the progression of various cancers, including colorectal cancer (CRC). SP1 (Sp1 transcription factor) is a well-recognized oncogene in CRC and is deemed to trigger the Wnt/β-catenin pathway. The present study was designed to investigate the role of circRNAs which shared the same pre-mRNA with SP1 in CRC cells.

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Article Synopsis
  • - Heavy metals enter water systems through natural processes and human activities, threatening human health, and a study in Wuhan assessed the distribution and risks of dissolved heavy metals (like V, Mn, Fe, Co, Ni, Zn, As, Mo, Sb) using various analytical methods.
  • - Results showed significant differences in heavy metal levels based on location, with natural sources influencing some metals (like Mn and Fe) and industrial emissions affecting others (like V and Zn); As was linked to urban and agricultural sources.
  • - The health risk assessment indicated that V and Sb could pose non-carcinogenic risks, while As was associated with both non-carcinogenic risks for children and potential carcinogenic risks for adults, highlighting the
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The major pathogenic feature of liver fibrosis is that oxidative stress motivation of hepatic stellate cells (HSCs) alters the balance between the synthesis and degradation of extracellular matrix (ECM) and HSCs into proliferative myofibroblasts. Green tea and selenium (Se) can protect the liver from damage; however, the precise mechanism of green tea and the action of Se in green tea on hepatic fibrosis remain unclear. Several studies have demonstrated the profibrogenic role of 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine receptor (5-HTR) 2A/2B in the liver.

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Thymoma is the most common tumor of the anterior mediastinum. Routine imaging methods such as computed tomography or magnetic resonance imaging often lead to misdiagnosis between thymoma and other thymic abnormalities. Therefore, urgently needed is to develop a new diagnostic strategy.

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Background Gastric cancer (GC) is the second most common cause of cancer-related death worldwide. Novel anticancer drugs against gastric cancer are urgently needed. Methods Compound 10 was designed and synthesized via a molecular hybridization strategy based on the natural product formononetin.

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Background: TRIP13 is highly expressed in several cancers and is closely connected with cancer progression. However, its roles on the growth and metastasis of hepatocellular carcinoma (HCC), and the underlying mechanism are still unclear.

Methods: Combining bioinformatics with previous studies, the correlation between TRIP13 and HCC was predicted.

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Efficient antigen presentation is indispensable for cytotoxic T lymphocyte (CTL)-mediated immunotherapy. B-lymphocytes propagated with CD40L have been developed as antigen-presenting cells (APCs), but this capacity needs further optimization. Here, we aimed to expand human B-lymphocytes on a large scale while maintaining their antigen-presenting ability by using both CD40L and B-cell activating factor (BAFF).

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Chronic kidney disease is becoming a global public health problem, which will usually cause uremia at the end stage of chronic kidney failure. So far, kidney transplant is the most effective and proper therapy for uremia, however, the short supply of matched donor kidney has been a persistent bottleneck for transplantation. HLA matching of HLA-A, -B and -DRB1 loci is very important for the allocation of kidney transplants.

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Rabbit antithymocyte globulin (ATG-F) is an extensively used induction agent. To our knowledge, no study to date has assessed reduced ATG-F dosage in children undergoing renal transplantation. This was a retrospective analysis of pediatric renal recipients in the Department of Kidney Transplantation, The First Affiliated Hospital of Zhengzhou University, from May 2007 to February 2013.

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