Diversity of intestinal microbiota and inflammatory cytokines after severe trauma.

Accumulating evidence has reported that the intestinal microbiota could play important roles in the occurrence and progression of severe trauma. However, the hypothesized potential targeted intestinal microbiota to mediate and regulate the levels of inflammatory cytokines and promote rapid recovery of body after severe trauma remains unclear. This study was aimed to explore the changes and correlation of intestinal microbiota and inflammatory cytokines in rats with severe crush and fracture trauma.

Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study.

Background: This study was designed to characterize gut microbiota changes of the patients with gastric cancer before and after the gastrectomy during their hospital staying periods.

Methods: 16S ribosomal RNA (rRNA) gene sequencing was used to evaluate differences in gut microbiota among patients with gastric cancer before and after the gastrectomy by comparing gut microbiota α diversity, β diversity, and structure composition at different taxonomic levels.

Results: A total of 120 fecal specimens were collected from 60 patients.

Integrated quantitative tracing for Karst groundwater contamination: A case study of landfill in Zunyi, Guizhou Province, China.

Sudden groundwater pollution in karst areas poses a serious threat to drinking water safety. Tracing contamination sources is crucial for managing and remediating groundwater pollution. Traditional tracing methods often lack accuracy, so this study combined multiple techniques to trace and quantify pollution sources near the municipal solid waste (MSW) landfill in Zunyi City, Guizhou Province, China.

Assessment of trace elements contamination and human health risk based on Monte Carlo simulation in a karst groundwater system affected by industrial activities.

Groundwater in karst regions is a vital drinking water source, but it is highly susceptible to contamination from industrial activities, which exacerbate pollution and pose health risks. This study investigated the concentration, spatial distribution, quality, health risks and sources of trace elements (TEs) in groundwater within a newly established industrial park in Guiyang, a representative city with a karst landscape. The results indicated that the trace element concentrations followed the order: Ti > Fe > Al > Ni > Cr > Mn > V > Cu > As > Co.

Significant effects of rural wastewater treatment plants in reducing microplastic pollution: A perspective from China's southwest area.

Sewage systems are a major source for microplastics in riverine exports to oceans. Urban areas are generally considered hotspots for microplastic discharge, whereas emissions from rural areas remain largely understudied. Hence, this study investigated the abundance, characteristics, and polymer types of microplastics in rural wastewater treatment plants (WWTPs) in Guiyang and estimated the annual microplastic emissions of China based on sewage discharge.

Quality appraisal of clinical practice guidelines for the management of Dysphagia after acute stroke.

Objectives: Dysphagia is a common complication in stroke patients, widely affecting recovery and quality of life after stroke. The objective of this systematic review is to identify the gaps that between evidence and practice by critically assessing the quality of clinical practice guidelines (CPGs) for management of dysphagia in stroke.

Methods: We systematically searched academic databases and guideline repositories between January 1, 2014, and August 1, 2023.

Distribution and characteristics of microplastics in an urban river: The response to urban waste management.

The rivers have been proven to be potential sources and the major transport pathways of microplastic (MP) in natural aquatic eco-systems, yet there is an absence of understanding the provenances and distribution dynamics of MP in fluvial water body of urban regions. The present investigation aimed to characterize the distribution and accumulation of MPs in both surface water and riverine bed sediments in a typical urban river (Nanming River, southwest China), during the dry and wet seasons of 2021. MP were detected throughout the entire sample set, with average surface water abundances of 750 ± 53 n/m and 693.

Study on the application effect of the family doctor contract service mode of 'basic package+personalised package' in elderly hypertension management in Chengdu, China: a retrospective observational study.

Objectives: We conducted this study to assess the application effect of the family doctor contract service mode of 'basic package+personalised package' in the management of hypertension patients.

Design: Observational study.

Setting: The study was conducted at a community health centre in Southwest China.

Rapid urbanization affects microplastic communities in lake sediments: A case study of Lake Aha in southwest China.

Effective management of pollutants in urban environments is crucial for achieving sustainable cities. Microplastics, as an emerging pollutant widely present in contemporary environments, have received widespread attention in recent years. However, limited studies have reported the impact of rapid urbanization on regional microplastics.

Distribution and removal mechanism of microplastics in urban wastewater plants systems via different processes.

Microplastic pollution threatens water systems worldwide. As one of the most important parts of city wastewater treatment, wastewater treatment plants are not only microplastics interception barriers but also emission sources. Water samples were collected from each sewage treatment plant stage and sludge from the sludge dewatering room.

Buffer zone-based trace elements indicating the impact of human activities on karst urban groundwater.

The tanglesome allocation of landscape types at various spatial dimensions is an important component influencing the quality of groundwater environment in karst cities. Trace elements can be used as indicators of the extent of impact on groundwater which is an effective means of tracing groundwater contamination. In this study, we studied the influence of landscape patterns on trace elements in groundwater of typical karst cities in Southwest China (Guiyang City) on a multi-spatial scale by using multivariate statistical analysis.

Coupled controls of the infiltration of rivers, urban activities and carbonate on trace elements in a karst groundwater system from Guiyang, Southwest China.

Hydrogeochemical processes of trace elements (TEs) are of considerable significance to river water and groundwater resource assessment and utilization in the karst region. Therefore, seven TEs were analyzed to investigate their contents, spatial variations, sources, and controlling factors in Guiyang, a typical karst urban area in southwest China. The results showed that the average content of TEs in river water (e.

Anthropogenic rare earth elements in urban lakes: Their spatial distributions and tracing application.

Anthropogenic activities associated with various new technologies are increasingly disrupting the geochemical cycles of rare earth elements (REEs). For example, samarium (Sm) and gadolinium (Gd) have emerged as microcontaminants in the natural waters of developed areas. Surface water samples of 13 urban lakes were collected in Wuhan, the largest city in central China, with a population of over 11 million.

Trace Metal Concentrations in Surface Water Along the Yangtze River in Chongqing, China: Urban Discharge Impacts.

Urban rivers are suffering from a significant anthropogenic impact. In this study, eight trace metals were investigated in surface water along the Yangtze River in Chongqing, China. The decreasing trend of trace metals was observed in water as Sr > Li > Mo > As > Cu > Ni > Cr > Co.

Hsa_circ_0026628 promotes the development of colorectal cancer by targeting SP1 to activate the Wnt/β-catenin pathway.

Circular RNAs (circRNAs) have been reported to play crucial roles in the progression of various cancers, including colorectal cancer (CRC). SP1 (Sp1 transcription factor) is a well-recognized oncogene in CRC and is deemed to trigger the Wnt/β-catenin pathway. The present study was designed to investigate the role of circRNAs which shared the same pre-mRNA with SP1 in CRC cells.

Protective Effect of Selenium-Enriched Green Tea on Carbon Tetrachloride-Induced Liver Fibrosis.

The major pathogenic feature of liver fibrosis is that oxidative stress motivation of hepatic stellate cells (HSCs) alters the balance between the synthesis and degradation of extracellular matrix (ECM) and HSCs into proliferative myofibroblasts. Green tea and selenium (Se) can protect the liver from damage; however, the precise mechanism of green tea and the action of Se in green tea on hepatic fibrosis remain unclear. Several studies have demonstrated the profibrogenic role of 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine receptor (5-HTR) 2A/2B in the liver.

Interleukin-8 as a candidate for thymoma identification and recurrence surveillance.

Thymoma is the most common tumor of the anterior mediastinum. Routine imaging methods such as computed tomography or magnetic resonance imaging often lead to misdiagnosis between thymoma and other thymic abnormalities. Therefore, urgently needed is to develop a new diagnostic strategy.

Discovery and anticancer evaluation of a formononetin derivative against gastric cancer SGC7901 cells.

Background Gastric cancer (GC) is the second most common cause of cancer-related death worldwide. Novel anticancer drugs against gastric cancer are urgently needed. Methods Compound 10 was designed and synthesized via a molecular hybridization strategy based on the natural product formononetin.

Silencing TRIP13 inhibits cell growth and metastasis of hepatocellular carcinoma by activating of TGF-β1/smad3.

Background: TRIP13 is highly expressed in several cancers and is closely connected with cancer progression. However, its roles on the growth and metastasis of hepatocellular carcinoma (HCC), and the underlying mechanism are still unclear.

Methods: Combining bioinformatics with previous studies, the correlation between TRIP13 and HCC was predicted.

Efficient generation of antigen-specific CTLs by the BAFF-activated human B Lymphocytes as APCs: a novel approach for immunotherapy.

Efficient antigen presentation is indispensable for cytotoxic T lymphocyte (CTL)-mediated immunotherapy. B-lymphocytes propagated with CD40L have been developed as antigen-presenting cells (APCs), but this capacity needs further optimization. Here, we aimed to expand human B-lymphocytes on a large scale while maintaining their antigen-presenting ability by using both CD40L and B-cell activating factor (BAFF).

Comparison of HLA-A, -B and -DRB1 Loci Polymorphism between Kidney Transplants of Uremia Patients and Healthy Individuals in Central China.

Chronic kidney disease is becoming a global public health problem, which will usually cause uremia at the end stage of chronic kidney failure. So far, kidney transplant is the most effective and proper therapy for uremia, however, the short supply of matched donor kidney has been a persistent bottleneck for transplantation. HLA matching of HLA-A, -B and -DRB1 loci is very important for the allocation of kidney transplants.

Reduced ATG-F dosage for induction in pediatric renal transplantation: a single-center experience.

Rabbit antithymocyte globulin (ATG-F) is an extensively used induction agent. To our knowledge, no study to date has assessed reduced ATG-F dosage in children undergoing renal transplantation. This was a retrospective analysis of pediatric renal recipients in the Department of Kidney Transplantation, The First Affiliated Hospital of Zhengzhou University, from May 2007 to February 2013.