LTBR acts as a novel immune checkpoint of tumor-associated macrophages for cancer immunotherapy.

Tumor-associated macrophages (TAMs) greatly contribute to immune checkpoint inhibitor (ICI) resistance of cancer. However, its underlying mechanisms and whether TAMs can be promising targets to overcome ICI resistance remain to be unveiled. Through integrative analysis of immune multiomics data and single-cell RNA-seq data (iMOS) in lung adenocarcinoma (LUAD), lymphotoxin β receptor () is identified as a potential immune checkpoint of TAMs, whose high expression, duplication, and low methylation are correlated with unfavorable prognosis.

Phenotypic comparison and the potential antitumor function of immortalized bone marrow-derived macrophages (iBMDMs).

Introduction: Macrophages are an important component of innate immunity and involved in the immune regulation of multiple diseases. The functional diversity and plasticity make macrophages to exhibit different polarization phenotypes after different stimuli. During tumor progression, the M2-like polarized tumor-associated macrophages (TAMs) promote tumor progression by assisting immune escape, facilitating tumor cell metastasis, and switching tumor angiogenesis.

STING strengthens host anti-hantaviral immunity through an interferon-independent pathway.

Hantaan virus (HTNV), the prototype virus of hantavirus, could escape innate immunity by restraining type I interferon (IFN) responses. It is largely unknown whether there existed other efficient anti-hantaviral tactics in host cells. Here, we demonstrate that the stimulator of interferon genes (STING) strengthens the host IFN-independent anti-hantaviral immunity.

[The role of intestinal immune cells in regulation of fatty liver disease progress through gut-liver axis].

Fatty liver disease is one of the most prevalent chronic liver disease worldwide and the gut-liver axis is recognized as increasingly prominent in fatty liver disease. Intestinal dysfunction can affect the occurrence or progression of liver disease, therein, validating the critical role of the intestinal immune cells. Enormous literature reported that macrophages, lymphocyte, dendritic cells (DCs) and other immune cells in the gut as well as their subsets may regulate the fatty liver disease progression via different mechanisms, including disruption of intestinal barrier, dysregulation of intestinal lipid transporters and mediating immune cell migration to liver.

CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation.

CD169, a specific marker for macrophages, is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family which acts as an adhesion molecule implicated in cell-cell interaction via sialylated glycoconjugates. Although CD169+ macrophages have been found to participate in erythroblastic island (EBI) formation and support erythropoiesis under homeostasis and stress, the exact role of CD169 and its counter receptor in EBI remains unknown. Herein, we generated CD169-CreERT knock-in mice and investigated the function of CD169 in EBI formation and erythropoiesis using CD169-null mice.

Synthesis of Graphene Oxide Modified Magnetic Chitosan Having Skin-Like Morphology for Methylene Blue Adsorption.

In this work, a novel magnetic biomass adsorbent was synthesized by a simple method. The adsorbent prepared from chitosan, graphene oxide and CoFe₂O₄ with a 'skin-like' morphology had a strong adsorption capacity for methylene blue adsorption and was easily separated from the liquid. The synthesized samples were characterized by scanning electron microscope, energy dispersive spectroscopy, fourier transform infrared spectroscopy and X-ray diffractomer.

Green synthesis of magnetic 3D bio-adsorbent by corn straw core and chitosan for methylene blue removal.

In this work, a novel bio-adsorbent with a unique structure was prepared through one-step crosslinking in the emulsion using corn straw core (CSC), CoFeO and chitosan (CS) as raw materials for adsorption of methylene blue (MB). The preparation method of the adsorbent was simple and environmentally friendly. In the adsorbent, the agricultural waste of CSC acted as scaffold and was wrapped with CS.