Synthesized akhtenskites remove ammonium and manganese from aqueous solution: removal mechanism and the effect of structural cations.

Ammonium and manganese removal by tunnel-structured manganese oxide is still enigmatic. Herein, tunnel-structured akhtenskites with different structural cations (Na-MnO , Mg-MnO Ca-MnO , Fe-MnO ) were synthesized by the KMnO and Mn reaction in the presence of different metal cations, and were used to remove ammonium and manganese from aqueous solution. The results of the batch adsorption experiments indicated that akhtenskites effectively removed NH and Mn, and the removal process fitted the pseudo-second-order model.

In-solution direct oxidative coupling for the integration of sulfur/selenium into DNA-encoded chemical libraries.

Sulfur/selenium-containing electron-rich arenes (ERAs) exist in a wide range of both approved and investigational drugs with diverse pharmacological activities. These unique chemical structures and bioactive properties, if combined with the emerging DNA-encoded chemical library (DEL) technique, would facilitate drug and chemical probe discovery. However, it remains challenging, as there is no general DNA-compatible synthetic methodology available for the formation of C-S and C-Se bonds in aqueous solution.

Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells.

Membrane proteins on the cell surface perform a myriad of biological functions; however, ligand discovery for membrane proteins is highly challenging, because a natural cellular environment is often necessary to maintain protein structure and function. DNA-encoded chemical libraries (DELs) have emerged as a powerful technology for ligand discovery, but they are mainly limited to purified proteins. Here we report a method that can specifically label membrane proteins with a DNA tag, and thereby enable target-specific DEL selections against endogenous membrane proteins on live cells without overexpression or any other genetic manipulation.