Effects of icariin on the fracture healing in young and old rats and its mechanism.

Context: Icariin has attracted increasing attention because of its wide variety of pharmacological effects.

Objective: This study investigates whether icariin could promote fracture healing in young and old rats and its mechanisms.

Materials And Methods: A Wistar rat model for the tibia fracture in relatively young and old rats, respectively, was established.

Icariin Accelerates Fracture Healing Activation of the WNT1/β-catenin Osteogenic Signaling Pathway.

Background: Icariin has been shown to enhance bone formation.

Objective: The present study aimed to investigate whether icariin also promotes bone fracture healing and its mechanisms.

Methods: First, we isolated and cultured rat bone marrow stromal cells (rBMSCs) with icariincontaining serum at various concentrations (0%, 2.

Curcumin improves neurofunctions of 6-OHDA-induced parkinsonian rats.

Our previous study has demonstrated that curcumin (CM), a natural ingredient isolated from Zingiberaceae, exerts the effect of inhibiting hippocampal injury in 6-hydroxydopamine (6-OHDA)-induced parkinsonian rat. However, the potential effect of CM on 6-OHDA-injured substantia nigra (SN) needs to be investigated. This study aimed to further evaluate the therapeutic effectiveness of CM against damaged SN in rats.

Neuroprotective effect of curcumin on hippocampal injury in 6-OHDA-induced Parkinson's disease rat.

Clinically, Parkinson's disease (PD)-related neuronal lesions commonly occur. The purpose of this study is to investigate potential therapeutic effect of curcumin against hippocampal damage of 6-hydroxydopamine (6-OHDA)-PD rat model. These results showed that curcumin significantly increased the body weight of 6-OHDA-impaired rats (P<0.