Quantitative and qualitative assessment of evaporative dry eye post intense pulsed light therapy, a prospective study.

Purpose: This study aimed to determine the effect of intense pulsed light (IPL) treatment on meibomian gland disease.

Settings And Design: This is a prospective interventional study.

Methods: Seventy eyes of patients with dry eye disease undergoing three sessions of IPL therapy, 15 days apart, were included.

Smart and advanced nanocomposites of rGO-based Ni-doped CoO/TiO for next-level photocatalysis and gas sensing application.

The rGO-based 5% Ni-doped CoO/TiO (GNCT) p-n heterojunction nanocomposite was synthesized using hydrothermal method. The resulting nanocomposite's morphology, structure, surface area, elemental composition, electrical and optical properties were thoroughly examined using a variety of techniques. The GNCT nanomaterial achieved an impressive 99.

From Genetics to Psychosocial Functioning: Unraveling the Mediating Roles of Cognitive Reserve, Cognition, and Negative Symptoms in First-Episode Psychosis.

Background: Studies have shown associations between polygenic risk scores for educational attainment (PRS), cognitive reserve (CR), cognition, negative symptoms (NS), and psychosocial functioning in first-episode psychosis (FEP). However, their specific interactions remain unclear. This study aimed to investigate the mediating roles of CR, cognition, and NS in the relationship between PRS and psychosocial functioning one year after a FEP.

Association of Iron Deficiency Anaemia With the First Episode of Febrile Seizure in Children.

Introduction Febrile seizures are the most common type of seizure in neurologically healthy children under six years of age. Iron deficiency is a prevalent micronutrient deficiency worldwide, though it is medically preventable and treatable. In many developing countries, anaemia remains a significant concern in young children.

Accuracy of acetabular cup positioning in robotic-assisted total hip arthroplasty: a CT-based evaluation.

Introduction: Robot-assisted instrumentation during total hip arthroplasty (THA) has the potential to improve acetabular cup positioning. This study aimed to evaluate the precision of robotic-arm-assisted THA (rTHA) and assess whether the system can provide accurate cup positioning comparable to conventional THA (cTHA).

Methods: A single-center prospective cohort study consisting of 151 patients who underwent THA (108 rTHA and 43 cTHA).

A prospective, multicentre study evaluating safety and efficacy of a fixed dose combination of Remogliflozin etabonate, Vildagliptin, and Metformin in Indian patients with type 2 diabetes mellitus (Triad-RMV).

Aims: The ICMR INDIAB-17 study revealed a diabetes prevalence of 11.4% in India, emphasizing the need for effective treatment for glycemic control. A Phase IV study was conducted to evaluate the safety and efficacy of a Fixed Dose Combination (FDC) of Remogliflozin, Metformin and Vildagliptin (RMV) in Type 2 Diabetes Mellitus (T2DM) patients uncontrolled on Metformin plus SGLT2 inhibitor or Metformin plus DPP4 inhibitor dual therapy.

Synthesis of Spin-Labeled α-/β-Galactosylceramides and Glucosylceramides as Electron Paramagnetic Probes.

α-/β-Galactosylceramide (GalCer) and glucosylceramide (GlcCer) derivatives having a radical label at the 6--position suitable for electron paramagnetic resonance spectroscopic studies were synthesized by a diversity-oriented strategy that is highlighted by the efficient glycosylation of a lipid precursor and late-stage ceramide assembly to enable lipid diversification. The strategy was also utilized to synthesize natural α-/β-GalCers and GlcCers. Furthermore, the involved azido-intermediates are flexible platforms to access various other GalCer and GlcCer derivatives.

Deep learning algorithm on H&E whole slide images to characterize alterations frequency and spatial distribution in breast cancer.

The tumor suppressor is frequently mutated in hormone receptor-negative, HER2-positive breast cancer (BC), contributing to tumor aggressiveness. Traditional ancillary methods like immunohistochemistry (IHC) to assess functionality face pre- and post-analytical challenges. This proof-of-concept study employed a deep learning (DL) algorithm to predict mutational status from H&E-stained whole slide images (WSIs) of BC tissue.

Confronting Vaccine Hesitancy in India: A Vital Call for Unified Action.

In India, vaccine hesitancy is one of the major hurdles to attaining widespread immunity against communicable diseases. Vaccines play a significant role, as was evident during the COVID-19 pandemic. However, factors such as misinformation, cultural beliefs together with distrust in healthcare providers are some of the barriers encountered during mass vaccination.

Risk Factors and Predictors of Outcomes in Hypoxic-Ischemic Encephalopathy in Neonates.

Background Hypoxic-ischemic encephalopathy (HIE) in neonates results from oxygen deprivation at birth, often leading to long-term neurological issues like cerebral palsy. Early detection is key to improving outcomes, but HIE remains a significant cause of neonatal complications. Here we aim to study the risk factors and predictors of outcome in moderate to severe HIE in inborn Term babies in the neonatal intensive care unit (NICU) Methods This prospective observational study was conducted in the NICU at a tertiary care center between August 2022 and July 2024.

Antimicrobial Resistance Profile of Enterococcal Isolates From Clinical Specimens at a Tertiary Care Hospital in Western Maharashtra, India.

Background , once benign intestinal flora, has transformed into formidable nosocomial pathogens as a result of the accelerated emergence of antibiotic resistance represents a major global health challenge, particularly within hospital settings. has grown more prevalent in nosocomial infections, such as urinary tract infections (UTIs), surgical site infections (SSIs) and bacteremia. The potential emergence of vancomycin-resistant (VRE) strains further complicates treatment choices for multi-drug resistant (MDR) infections.

Robert Koch: From Anthrax to Tuberculosis - A Journey in Medical Science.

The pioneering German physician and microbiologist Heinrich Hermann Robert Koch (1843-1910) made pivotal contributions to the field of bacteriology, significantly advancing the germ theory of disease. His groundbreaking research in identifying the causative agents of anthrax, tuberculosis, and cholera revolutionized medical science and public health. Koch's development of essential microbiological techniques, such as using agar for bacterial cultures and introducing the Petri dish, transformed laboratory practices.

Plaseval: a framework for comparing and evaluating plasmid detection tools.

Background: Plasmids play a major role in the transfer of antimicrobial resistance (AMR) genes among bacteria via horizontal gene transfer. The identification of plasmids in short-read assemblies is a challenging problem and a very active research area. Plasmid binning aims at detecting, in a draft genome assembly, groups (bins) of contigs likely to originate from the same plasmid.

Palladium-Catalyzed, Regio-/Stereo- and Enantiospecific Anti-Carboxylation of Unactivated Internal Allenes.

We report herein a directing group-controlled, palladium-catalyzed, regio-, stereo-, and enantiospecific anti-carboxylation of unactivated, internal allenes enabled via the synergistic interplay of a rationally designed bidentate directing group, palladium catalyst, and a multifunctional acetate ligand. The corresponding trans allyl ester was obtained in excellent yields with exclusive δ-regioselectivity and anti-carboxypalladation stereocontrol. The acetate ligand of the palladium catalyst controls the regio-, stereo- and enantioselectivity in the desired transformation.

Superiorly Based Preauricular Flap for Total Ear Lobe Reconstruction Following a Large Keloid Excision.

A large keloid on the right earlobe that extended to the infraauricular region was the reason for the 42-year-old woman's referral for treatment. The entire thickness of the earlobe was implicated in the surgical defect that resulted from the severe keloid excision. We employed a straightforward technique to provide a pleasing appearance while repairing the entire lobe in a single stage without the need for grafts.

Electrochemical Reduction of Nitrogen to Ammonia Using Zinc Telluride.

Electrosynthesis of ammonia (NH), an important constituent molecule of various commercial fertilizers, is a promising and sustainable alternative strategy compared with the century-old Haber-Bosch process. Herein, zinc telluride (ZnTe) is demonstrated as an efficient electrocatalyst for reducing nitrogen (N) under ambient conditions to NH. In this simple chemical strategy, Zn preferentially binds N over hydrogen (H), and Te, by virtue of its superior electronic properties, enhances the electrocatalytic activity of ZnTe.

A dataset revolutionizing Indian bay leaf analysis.

Indian bay leaf is a crucial spice in Indian cuisine. However, its quality and authenticity are often compromised. To address this, we introduce The Digital Indian Bay leaf dataset, a comprehensive collection of high-resolution 5696 images capturing diverse bay leaf samples under controlled conditions.

Modified OXIS Classification of Interproximal Contacts of Primary Canines and Its Prevalence in Six-to-Nine-Year-Olds in the Delhi National Capital Region: A Cross-Sectional Study.

Introduction: The modified OXIS (O - open contact, X - point contact, I - straight contact, S - curved contact) classification provides a useful framework for assessing interproximal contacts in primary canines and predicting caries risk. The study aimed to assess the incidence of modified OXIS classification of canine interproximal contacts in six-to-nine-year-old children from the Delhi National Capital Region (NCR) population.

Methods: A cross-sectional study was conducted to assess the interproximal contact areas between primary canine and first molar among six-to-nine-year-old children (n=400) according to the modified OXIS classification using the die stone study model.

Pioneering Hand Hygiene: Ignaz Semmelweis and the Fight Against Puerperal Fever.

Hungarian physician Ignaz Semmelweis (1818-1865) revolutionized medical practice through his introduction of antiseptic procedures. This breakthrough disrupted the chain of infection among new mothers and their infants, leading to dramatically reduced mortality rates from puerperal fever across continental Europe. Semmelweis faced significant resistance and disbelief when he argued through meticulous, empirically-based evidence that proper hand hygiene may prevent infection.

Non-mechanical beam steering for high-speed optical wireless communications via electrowetting on dielectric.

Electrowetting on dielectric (EWOD) is used for non-mechanical optical beam steering (OBS) in optical communication systems. High-capacitance ion gel is used to construct an efficient electrowetting interface that facilitates dynamic OBS. This integration facilitates precise control of beam steering and data transmission efficiency in optical wireless communication systems.

Molecular phylogenetic and biogeographic evidence of Willd. (Acanthaceae, Barlerieae) focusing on Indian endemics.

Willd., a genus belonging to the Acanthaceae family, is primarily distributed in tropical and subtropical regions worldwide, encompassing approximately 153 species. While considerable morphological research has been conducted on , it has not completely dispelled taxonomic ambiguities and conflicting interpretations.