Publications by authors named "Shila Mang-Fatehi"
Article Synopsis
- Circadian rhythms regulate key molecular processes in living organisms, and their disruption can lead to severe health issues, including cancer.
- A systems biology approach was used to analyze various colorectal and skin cancer cell lines, revealing distinct patterns of circadian oscillation and specific genes that differentiate these patterns.
- The study identified the RAS/MAPK pathway's role in disturbing circadian rhythms, showing that oncogene overexpression (like RAS) can negatively impact the circadian clock's functioning.
Most malignant features of cancer cells are triggered by activated oncogenes and the loss of tumor suppressors due to mutation or epigenetic inactivation. It is still unclear, to what extend the escape of emerging cancer cells from recognition and elimination by the immune system is determined by similar mechanisms. We compared the transcriptomes of HCT116 colorectal cancer cells deficient in DNA methyltransferases (DNMTs) and of cells, in which the RAS pathway as the major growth-promoting signaling system is blocked by inhibition of MAPK.
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