Publications by authors named "Shikun Deng"
Article Synopsis
- A new condition called invasive Klebsiella pneumoniae liver abscess syndrome (IKPLAS) affects the liver and can spread to other parts of the body, leading to severe complications like endogenous endophthalmitis (EE) and isolated optic neuritis (ON).
- A rare case of a 33-year-old man developed isolated retrobulbar optic neuritis after experiencing severe pneumonia, where cerebrospinal fluid analysis indicated elevated protein levels but negative tests for specific antibodies.
- The patient was successfully treated with intravenous methylprednisolone and immunoglobulin, suggesting that the optic neuritis was a para-infectious reaction to the Klebsiella pneumoniae infection, potentially causing damage to the optic nerve and visual impairment
Article Synopsis
- - Niemann-Pick type C (NPC) disease results from mutations in NPC1 or NPC2 genes, leading to the accumulation of cholesterol in late endosomes/lysosomes, and researchers are exploring LBPA (lysobisphosphatidic acid) as a therapeutic agent to reduce this accumulation.
- - Studies indicate that different stereoisomers of LBPA are effective in reducing cholesterol levels in NPC1-deficient human fibroblast cells, with the presence of an 18:1 acyl chain being particularly significant for enhancing cholesterol clearance.
- - Further experiments suggest that while phosphatidylglycerol (PG) can also reduce cholesterol, it does not convert to LBPA effectively, highlighting that LBPA itself is essential for promoting cholesterol
is rare to associated with human infection, which may cause abscesses in abdominal cavity, liver, breast, and spine. is very difficult to be cultivated in regular manner; detection of 16S rRNA sequence is the main evidence for infection. The clinical manifestations of infection resemble other agents of Nocardia, Tuberculosis and non-tuberculous Mycobacterium (NTM) due to their morphologic similarities.
View Article and Find Full Text PDFInduction of long-term potentiation (LTP) in excitatory neurons triggers a large transient increase in the volume of dendritic spines followed by decays to sustained size expansion, a process termed structural LTP (sLTP) that contributes to the cellular basis of learning and memory. Although mechanisms regulating the early and sustained phases of sLTP have been studied intensively, how the acute spine enlargement immediately after LTP stimulation is achieved remains elusive. Here, we report that endophilin A1 orchestrates membrane dynamics with actin polymerization to initiate spine enlargement in NMDAR-mediated LTP.
View Article and Find Full Text PDFRepeated low-level exposure to sarin results to hippocampus dysfunction. Metabonomics involves a holistic analysis of a set of metabolites in an organism in the search for a relationship between these metabolites and physiological or pathological changes. The objective of the present study was to evaluate the effects of repeated exposure to low-level sarin on the metabonomics in hippocampus of a guinea pig model.
View Article and Find Full Text PDFEndophilin A1 is a member of the N-BAR domain-containing endophilin A protein family that is involved in membrane dynamics and trafficking. At the presynaptic terminal, endophilin As participate in synaptic vesicle recycling and autophagosome formation. By gene knockout studies, here we report that postsynaptic endophilin A1 functions in synaptic plasticity.
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