Azo-Based Hypoxia-Responsive Self-Assembly Near-Infrared Fluorescent Nanoprobe for In Vivo Real-Time Bioimaging of Tumors.

Hypoxia is an obvious characteristic of cancer, especially solid tumors. which may give rise to the expansion of invasion and metastasis. Exploring near-infrared (NIR) nanoprobes that could accurately evaluate the degree of hypoxia will contribute to the assessment of the degree of malignant neoplasms, so as to adopt more accurate and individualized treatment options Here, we have developed a self-assembled NIR organic nanoprobe to specifically and authoritatively detect the oxygen concentration and to evaluate the level of hypoxia.

γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy.

Precise treatment of tumors is attracting increasing attention. Molecular probes simultaneously demonstrating the diagnostic signal and pharmacological effect in response to tumor microenvironment are highly desired. γ-glutamyl transpeptidase (GGT) is a biomarker with significantly up-regulated expression in the tumor area.

Near-infrared fluorescent chemodosimeter for real-time in vivo evaluation of HS-release efficiency of prodrug.

Hydrogen sulfide (H2S) is a significant gasotransmitter. A deficiency in H2S might contribute to some serious diseases. The development of H2S drugs has received a great deal of attention.

A complete mitochondrial genome sequence of Asian black bear Sichuan subspecies (Ursus thibetanus mupinensis).

We obtained the complete mitochondrial genome of U.thibetanus mupinensis by DNA sequencing based on the PCR fragments of 18 primers we designed. The results indicate that the mtDNA is 16,868 bp in size, encodes 13 protein genes, 22 tRNA genes, and 2 rRNA genes, with an overall H-strand base composition of 31.