Acupoint Autohemotherapy Alleviates Airway Inflammation in Asthmatic Rats via Upregulating Expression of Hemeoxygenase-1.

Importance: Acupoint autohemotherapy (AA), a therapeutic technique involving the subcutaneous injection of autologous blood into acupoints, has been empirically validated as safe and effective for treating asthma by alleviating symptoms and decreasing acute attacks, though its mechanism is not well understood.

Objective: The role of heme oxygenase-1 (HO-1) in AA-induced suppression of asthmatic airway inflammation is examined.

Methods: Twenty rats were assigned randomly to four groups, namely the Control, OVA, OVA + AA, and (OVA + Snpp) + AA.

Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment.

Programmed cell death protein-1 (PD-1) inhibitors are increasingly utilized in the treatment of lung cancer (LC). Combination therapy has recently gained popularity in treating LC. This study aimed to assess the efficacy of combining Astragaloside IV (AS-IV) and anti-PD-1 in LC.

Role of Thulium Laser and Holmium Laser in the Surgical Treatment of Benign Prostatic Hyperplasia: A Systemic Review and Meta-Analysis.

Background: Patients with benign prostatic hyperplasia are generally treated holmium laser enucleation of the prostate (HoLEP) and thulium laser enucleation of the prostate (ThuLEP). Therefore, it is important to analyze the several surgical procedures used for benign prostatic hyperplasia in terms of their role, effectiveness and safety.

Methods: We conducted a meta-analysis by searching databases of PubMed, Google Scholar, and Web of Science.

Preparation and anti-inflammatory effect of mercury sulphide nanoparticle-loaded hydrogels.

We successfully prepared mercury sulphide nanoparticle hydrogels by physical encapsulation method. The successfully prepared mercuric sulphide nanoparticle hydrogel was a zinc folate hydrogel, which showed an obvious porous structure with interconnected and uniformly distributed pores and a pore size range of about 20 μm. The maximum drug loading of the hydrogels was 3%, and the cumulative release degree was in accordance with the first-order kinetic equation Mt = 149.

Overexpression of hsa_circ_0001861 inhibits pulmonary fibrosis through targeting miR-296-5p/BCL-2 binding component 3 axis.

Pulmonary fibrosis is a progressive lung disorder. Evidence has shown that hsa_circular (circ)RNA_0001861 is dysregulated in pulmonary fibrosis. However, the detailed function of hsa_circRNA_0001861 in pulmonary fibrosis remains unexplored.

Carbon Nanoparticles in Mongolian Medicine Alleviate Acute Gastric Ulcer Induced by Ethanol by Regulating Fas/FasL Pathway.

Introduction: The consumption of large amounts of ethanol can directly lead to acute gastric mucosal bleeding, edema, and erosion, while long-term drinking has been associated with gastric ulcers. Previous research has demonstrated that Har Gabur, a traditional Mongolian medicine, alleviates gastric ulcers through the physical adsorption of its carbon components. It is well known that the immune response has an important role in gastric ulceration.

Sendeng-4 Suppressed Melanoma Growth by Induction of Autophagy and Apoptosis.

Sendeng-4 is a traditional Chinese medicine that has been successfully applied to anti-inflammatory diseases in clinical practice. Monomers within Sendeng-4 showed promising antitumor activity against lung cancer, colon cancer, and cutaneous cancer. However, potency of Sendeng-4 in melanoma has not been explored.

High energy density hybrid supercapacitor based on cobalt-doped nickel sulfide flower-like hierarchitectures deposited with nitrogen-doped carbon dots.

The exploration of advanced electrode materials with outstanding electrochemical properties is of considerable importance for hybrid supercapacitors but challenging. In this paper, an effective two-step solvothermal route is demonstrated to synthesize nitrogen-doped carbon dots (NCDs) decorated cobalt-doped nickel sulfide (Co-NiS) flower-like hierarchitectures. Because of the modification with NCDs and doping by cobalt atoms, the resulting Co-NiS/NCDs hierarchitectures exhibit an ultrahigh specific capacity up to 1240 C g-1 (2480 F g-1) at 1 A g-1 and a remarkable rate capability of 790.

Preparation and Characterization of Natural Quercetin-Based Mongolia Medicine Sendeng-4 Nanoemulsion (N-QUE-NE) and its Antibacterial Activity.

Introduction: Quercetin is the main active ingredient of Xanthoceras sorbifolia Bunge. Traditional compatibility theory of traditional Chinese medicine has typically reported a synergistic interaction among multiple components, while the synergistic effects of nanoemulsion have not been fully clarified.

Objective: The paper aims to study the preparation and characterization of quercetin-based Mongolia Medicine Sendeng-4 nanoemulsion (N-QUE-NE) and its antibacterial activity and mechanisms.

Biological roles of filamin a in prostate cancer cells.

Objective: This study aims to investigate the association of filamin A with the function and morphology of prostate cancer (PCa) cells, and explore the role of filamin A in the development of PCa, in order to analyze its significance in the evolvement of PCa.

Materials And Methods: A stably transfected cell line, in which filamin A expression was suppressed by RNA interference, was first established. Then, the effects of the suppression of filamin A gene expression on the biological characteristics of human PCa LNCaP cells were observed through cell morphology, in vitro cell growth curve, soft agar cloning assay, and scratch test.

Metal-organic framework derived Fe/FeC@N-doped-carbon porous hierarchical polyhedrons as bifunctional electrocatalysts for hydrogen evolution and oxygen-reduction reactions.

The development of simple and cost-effective synthesis methods for electrocatalysts of hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR) is critical to renewable energy technologies. Herein, we report an interesting bifunctional HER and ORR electrocatalyst of Fe/FeC@N-doped-carbon porous hierarchical polyhedrons (Fe/FeC@N-C) by a simple metal-organic framework precursor route. The Fe/FeC@N-C polyhedrons consisting of Fe and FeC nanocrystals enveloped by N-doped carbon shells and accompanying with some carbon nanotubes on the surface were prepared by thermal annealing of Zn[Fe(CN)]·xHO polyhedral particles in nitrogen atmosphere.

Organic-inorganic hybrid ZnS(butylamine) nanosheets and their transformation to porous ZnS.

Two-dimensional (2D) nanosheets possess the very essential features of nanomaterials, including quantum-confinement effects and unconventional reactivity, and are of special interest for a variety of promising applications. Here we report a facile chemical transformation strategy to prepare porous ZnS nanosheets via the organic-inorganic hybrid ZnS(butylamine) nanosheet-like precursor prepared from zinc diethyldithiocarbamate. The hybrid ZnS(butylamine) precursor show unique nanosheet-like structure composed by ZnS nanocluster region and non-crystalline region.

Morphological synthesis of Prussian blue analogue Zn3[Fe(CN)6]2⋅xH2O micro-/nanocrystals and their excellent adsorption performance toward methylene blue.

Prussian blue analogue Zn3[Fe(CN)6]2⋅xH2O (Zn-PBA) micro-/nanocrystals with well-defined spherical, cubic and polyhedral morphologies have been successfully synthesized by a simple room-temperature solution method. The morphologies and sizes of the micro-/nanocrystals can be easily tuned by HCl dosage and polymer additive. The as-prepared products are characterized by X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis and Brunauer Emmet Teller adsorption-desorption analysis.

[Recent researches of synthetic mercury sulfide in traditional medicine system].

Objective: Herein, the synthesis, component, microstructure and pharmacological and toxicology researches of the Synthetic Mercury Sulfide (S-HgS) a kind of common drug in Chinese, Mongolia, Tibetan medicine, and Indian medicine system were summarized. The similar cognition about mercury toxicity & pharmacological action from some Asian regions was analyzed, and it can supply some useful direction for the traditional Asian medicine system.

Method: Recent literatures both domestic and abroad were summarized and analyzed.

Morphology syntheses and properties of well-defined Prussian Blue nanocrystals by a facile solution approach.

Large-scale syntheses of Prussian Blue (PB) uniform nanocubes and nanospheres, together with an interesting PB micro-frame structure, have been achieved by direct dissociation of a single-source precursor K(3)[Fe(CN)(6)] with polyvinylprrolidone (PVP) as a capping and reducing agent. The reaction temperature has been proved to be a key factor for morphology development of PB nanocrystals, and the size of PB nanocrystals can be tuned by adjusting the feed ratio of K(3)[Fe(CN)(6)] to PVP and the concentration of K(3)[Fe(CN)(6)]. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), selected-area electron diffraction (SAED), and high resolution transmission electron microscopy (HRTEM) were used to characterize the resulting nanocrystals and investigate their growth mechanisms.