[The study of cognitive functions and the brain electrical activity in wakefulness and night sleep in patients with lobe tumors].

Objective: To study cognitive dysfunction and brain electrical activity in sleep-wakefulness cycle in patients with frontal lobe tumors.

Material And Methods: Twenty patients, aged 48.6±4.

[Night sleep organization in patients with primary brain tumor].

Aim: To study cycle organization of night sleep and analyze brain electrical activity during sleep in patients with primary brain tumor before and after surgical intervention.

Material And Methods: Ten patients, mean age 48.6±4.

[Some Approaches to Activation of Antitumor Resistance Mechanisms and Functional Analogs in Categories of Synergetics].

This paper briefly reviews the ways of activation of the antitumor resistance mechanisms developed on the basis of the concept of the periodic system of general nonspecific adaptational reactions of the body. The principles of the formation of effective influences by electromagnetic radiation using biologically active substances are described. A comparison of the criteria and conceptions of the theory of adaptational reactions to some concepts and categories of synergetics is made.

FEATURES OF THE ADAPTATION STATUS OF THE PATIENTS WITH DIFFERENCES IN THE PREVALENCE OF CANCER PROCESS IN BILIOPANCREATICODUODENAL ZONE AND IN THE VOLUME OF A SURGICAL INTERVENTION.

The differences in the type and tension of the general unspecific adaptational reactions in cancer patients with varying prevalence of the process in biliopancreaticoduodenal zone and volume of surgical intervention were revealed. It was shown prognostic significance of the numerical score of the type and tension of the adaptational reaction a day after pancreatoduodenal resection for the development of postoperative complications.

[Antitumor action and other regulatory effects of low intensity electromagnetic and chemical factors in experiment].

This paper presents a brief overview of the results of the original researches of biological responses induced by agents of cytostatic and regulatory actions in small doses, as well as weak electromagnetic radiation of different frequency bands. The possibility of obtaining the expressed antitumor, antistress and geroprotective effects has been shown. The question of the relation of system mechanisms of realization of these effects with structural rearrangements in biological fluids, as well as the promising directions for optimizing the therapeutic properties of the informational impacts are discussed.

[Effect of monochromatic red lighting potentiating antitumor action of cyclophosphamide injected with autoblood].

Blood was sampled from the caudal vein of rats, incubated with cyclophosphamide with autoblood, exposed to red light (0.31 Jcm2) and re-injected into the femoral vein. Lighting in conjunction with the antitumor action of the drug was followed by significant inhibition of large-size tumors, longer survival and development of integral criteria which describe cumulative antitumor effect.

[Influence of optical alternating magnetic field on cellular energy metabolism in rats bearing lymphosarcoma of Pliss].

Our investigation deals with prognosis of antitumor action of optical alternating magnetic field. It is designed to stimulate bioadaptive mechanisms taking place in peripheral blood from animals bearing Pliss' tumor. Due to its effect, antitumor defenses were stimulated and levels of dehydrogenases in blood lymphocytes tended to normalize.

[Experimental use of low-energy infrared laser radiation to stimulate antitumor effect of cyclophosphane].

The potential of increased antitumor effect of cyclophosphane used in conjunction with low-energy infra-red laser radiation was studied in sarcoma-45--bearing rats. Exposure to certain modes stimulated non-specific antitumor resistance and enhanced antitumor influence of the drug by reducing its damaging effect. Also, it inhibited refractory leukopenia and marked intoxication induced by antistressor reactions.

[Effect of low-intensity laser radiation on the functional potential of neutrophilic granulocytes in blood of tumor-bearing animals].

Peripheral blood was sampled for cytochemical assay of cationic proteins from three groups of animals--intact ones, those with tumor C45 and bearers of the same tumor treated with helium-laser radiation and chemotherapy. Radiotherapy involved such manifestations of enhanced nonspecific antitumor resistance and, in particular, mobilization of the cellular component, as increased number of neutrophils containing cationic protein granules and relatively high levels of such proteins in them. Cytochemical assay of cationic proteins in neutrophil granules may serve as a criterion of nonspecific antitumor resistance assessment.

[Role of the antioxidant system of the brain in the antineoplastic mechanism of ultra-low frequency magnetic fields].

The study deals with the possible effects of ultra low frequency magnetic fields (ULF MF) on carcinogenesis in the brain and oxidative metabolism disorders associated with it. Animals were exposed to modulated ULF MF at pathogenetically-sensitive stages of the "biochemical restructuring" of the body. This allowed to adjust carcinogenic development by extending latent period of tumor and life span of tumor-bearing animals.

[Morphofunctional features of lymph nodes, thyroid gland and testis of rats during adaptation reactions to stress and activation].

The morphofunctional state of lymphatic nodes, thyroid gland and testis have been studied with morphometric, cell photometric and biochemical methods in experiments on adult white rats under the influence of nonspecific adaptation stress and activation reactions caused by small doses of adrenaline (125 mg/kg and 5 mg/kg). The research showed that the changes in the structure and function of the lymphatic organs under stress and activation were markedly different. If stress results in depression of functional state of these organs, the activation reaction, on the contrary, stimulates it.

[Luminescent characteristics of the functional state of sarcoma 45 cells].

Various functional states of cells of sarcoma 45 in the course of its growth and regression were studied by photometry and spectral analysis using acridine orange. Fluorescent spectral analysis proved to be the most reliable procedure for quantitative evaluation of tumor cell function using the alpha-coefficient.

[Enhancement of antitumor resistance by means of small doses of adrenaline].

The antitumor effect of common nonspecific adaptation reactions of training and activation, obtained by small doses of adrenaline, was studied in the experiments on white rats with sarcoma 45,3,4-benz/a/-pyrene induced tumors and Biskind ovary tumor. Total resorption of the tumor was noted in all cases (55 rats), in which histological investigation of the thymus, lymph nodes, endocrinous glands and white cell count evidenced the development of the activation reaction, while with the training reaction there was only some retardation of tumor growth (51 rats). When it proved impossible to overcome a "chronic" tumor stress (45 rats), no antitumor effect was gained.