Publications by authors named "Shikha Rai"

Single-molecule fluorescence microscopy demands ultrahigh stability of single fluorophores with less photobleaching and essentially no intensity fluctuations on experimentally relevant time scales. In this respect, there is a need to design fluorescent probes with excellent photostability and long-lived dark transient states. Herein, we report the site-specific synthesis of gold nanoclusters (Au NCs) on DNA origami.

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This study investigates the coupling of mercury sulfide (HgS) and copper oxide (CuO) nanoparticles with metal-organic frameworks (MOFs) as a support material for enhancing the electrocatalytic oxygen evolution reaction (OER). The integration of HgS and CuO into the MOF framework aims to leverage the unique electronic and structural properties of both the nanoparticles and the MOFs to improve catalytic performance. Metal-organic frameworks (MOFs), particularly ZIF-67, are investigated for their potential to catalyze water-splitting reactions due to their high porosity and large specific surface areas.

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Lobular capillary hemangioma is a benign vascular tumor predominantly seen in pediatric populations. A 34-year-old male developed a reddish nodular mass on the upper eyelid of his left eye. An excisional biopsy was performed, and a histopathological examination of the specimen revealed proliferative vessels lined by increased endothelial cells, devoid of nuclear atypia.

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Article Synopsis
  • - The combination of DNA origami and surface-enhanced Raman spectroscopy (SERS) has led to significant advancements in detecting single-molecule proteins, improving biomedical diagnostics.
  • - By using DNA origami, researchers have created gold nanorod structures for enhanced SERS signal, allowing for better detection of proteins.
  • - The study specifically focused on the epidermal growth factor receptor (EGFR), showing that gold nanorod dimer assemblies can effectively identify single protein signals, which is crucial for cancer research.
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The development of effective methods for the detection of protein misfolding is highly beneficial for early stage medical diagnosis and the prevention of many neurodegenerative diseases. Self-assembled plasmonic nanoantennas with precisely tunable nanogaps show extraordinary electromagnetic enhancement, generating extreme signal amplification imperative for the design of ultrasensitive biosensors for point of care applications. Herein, we report the custom arrangement of Au nanobipyramid (Au NBP) monomer and dimer nanoantennas engineered precisely based on the DNA origami technique.

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