Publications by authors named "Shikha Kushwah"
Background and objective: Colorectal Cancer (CRC) affects the colon and rectum part of the digestive system and is a significant global health concern, with approximately 1.1 million new cases annually. It ranks second in cancer-related deaths.
View Article and Find Full Text PDFIntroduction: Alzheimer's disease (AD) is an alarmingly prevalent worldwide neurological disorder that affects millions of people and has severe effects on cognitive functions. The amyloid hypothesis, which links AD to Aβ (amyloid beta) plaque aggregation, is a well-acknowledged theory. The β-secretase (BACE1) is the main cause of Aβ production, which makes it a possible target for therapy.
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- * A total of 770 CRC samples were examined, revealing 170 significant DEGs, and a prognostic classification model based on 33 important genes achieved perfect accuracy and performance metrics.
- * Further analysis highlighted the GLP2R and VSTM2A genes, which were downregulated in tumor samples and correlated with immune cell infiltration, suggesting their critical roles in CRC progression and immune response suppression.
Alzheimer's is a chronic neurodegenerative disease where amyloid-beta (Aβ) plaques and neurofibrillary tangles are formed inside the brain. It is also characterized by progressive memory loss, depression, neuroinflammation, and derangement of other neurotransmitters. Due to its complex etiopathology, current drugs have failed to completely cure the disease.
View Article and Find Full Text PDFPerspectives on the Role of as a Therapeutic Target for Alzheimer's Disease.
J Alzheimers Dis Rep
December 2021
Alzheimer's disease (AD) is a neurodegenerative disease that is coupled with chronic cognitive dysfunction. AD cases are mostly late onset, and genetic risk factors like the Apolipoprotein E () play a key role in this process. 2, 3, and 4 are three key alleles in the human gene.
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