Biosynthesis and bioactivities of triterpenoids from Centella asiatica: Challenges and opportunities.

Centella asiatica (L.) Urban is an herbaceous perennial plant that has long been widely used in traditional medicine, due to its diverse wound-healing, neuroprotection, antioxidant and anti-inflammatory properties. The major functional bioactive secondary metabolites are the triterpenoids asiatic acid, madecassic acid, asiaticoside and madecassoside, collectively known as centellosides.

Good Cycling Stabilities of Sn/SnO/C/S Composite Electrodes with Introduced Active Tin Atoms in Li-S Batteries.

Polysulfides are easily dissolved in the electrolyte of Li-S batteries after long cycles. Sn atom modification electrodes are beneficial for improving cycling stabilities of Li-S batteries. However, the influence of Sn atoms on the structure and electrochemical performance of SnO/C composite materials is not explored.

Zn promoted GaZrO Ternary Solid Solution Oxide Combined with SAPO-34 Effectively Converts CO to Light Olefins with Low CO Selectivity.

We proposed a new strategy for CO hydrogenation to prepare light olefins by introducing Zn into GaZrO to construct ZnGaZrO ternary oxides, which was combined with SAPO-34 to prepare a high-performance ZnGaZrO/SAPO-34 tandem catalyst for CO hydrogenation to light olefins. By optimizing the Zn doping content, the ratio and mode of the two-phase composite, and the process conditions, the 3.5 %ZnGaZrO/SAPO-34 tandem catalyst showed excellent catalytic performance and good high-temperature inhibition of the reverse water-gas shift (RWGS) reaction.

Enhancing Glycosylation of Flavonoids by Engineering the Uridine Diphosphate Glucose Supply in .

Glycosylation can enhance the solubility and stability of flavonoids. The main limitation of the glycosylation process is low intracellular uridine diphosphate glucose (UDPG) availability. This study aimed to create a glycosylation platform strain in BL21(DE3) by multiple metabolic engineering of the UDPG supply.

A General and Convenient Peptide Self-Assembling Mechanism for Developing Supramolecular Versatile Nanomaterials Based on The Biosynthetic Hybrid Amyloid-Resilin Protein.

Self-assembling peptides are valuable building blocks to fabricate supramolecular biomaterials, which have broad applications from biomedicine to biotechnology. However, limited choices to induce different globular proteins into hydrogels hinder these designs. Here, an easy-to-implement and tunable self-assembling strategy, which employs Ure2 amyloidogenic peptide, are described to induce any target proteins to assemble into supramolecular hydrogels alone or in combination with notable compositional control.

Blastocystis infection among diarrhea outpatients in Ningbo, Southeast China: A potential zoonotic health threat.

Background: Blastocystis is one of the important zoonotic parasites which can infect humans and various animals worldwide and has become a growing global public health concern. The study aims to obtain the data of Blastocystis infection and the information of the genetic characteristic.

Methods: In the present study, 489 fecal samples were collected from diarrhea outpatients in Ningbo, Zhejiang province, and were examined the presence of Blastocystis by polymerase chain reaction combined with sequencing.

First report on occurrence and genotypes of Enterocytozoon bieneusi, Cryptosporidium spp. and Cyclospora cayetanensis from diarrheal outpatients in Ningbo, Southeast China.

Enterocytozoon bieneusi, Cryptosporidium spp. and Cyclospora cayetanensis are three important zoonotic pathogens which were a major cause of foodborne or waterborne intestinal diseases in humans and animals. However, very little data about occurrence and genotypes of the three parasites in Ningbo in the south wing of the Yangtze River Delta, China, which is important for a tourist city.

Microstructured BN Composites with Internally Designed High Thermal Conductivity Paths for 3D Electronic Packaging.

Miniaturized and high-power-density 3D electronic devices pose new challenges on thermal management. Indeed, prompt heat dissipation in electrically insulating packaging is currently limited by the thermal conductivity achieved by thermal interface materials (TIMs) and by their capability to direct the heat toward heat sinks. Here, high thermal conductivity boron nitride (BN)-based composites that are able to conduct heat intentionally toward specific areas by locally orienting magnetically functionalized BN microplatelets are created using magnetically assisted slip casting.

Applied evolution: Dual dynamic regulations-based approaches in engineering intracellular malonyl-CoA availability.

Malonyl-CoA is an important building block for microbial synthesis of numerous pharmaceutically interesting or fatty acid-derived compounds including polyketides, flavonoids, phenylpropanoids and fatty acids. However, the tightly regulated intracellular malonyl-CoA availability often impedes overall product formation. Here, in order to unleash this tightly cellular behavior, we present evolution: dual dynamic regulations-based approaches to write artificial robust and dynamic function into intricate cellular background.

Efficient Production of Orientin and Vitexin from Luteolin and Apigenin Using Coupled Catalysis of Glycosyltransferase and Sucrose Synthase.

Orientin and vitexin are flavone 8-glycosides that exhibit many biological characteristics. This study aimed to establish a two-enzyme-coupled catalytic strategy to enhance the biosynthesis of orientin and vitexin from apigenin and luteolin, respectively. The glucosyltransferase (TcCGT1) gene from was cloned and expressed in BL21(DE3).

Neodymium oxide (NdO) coupled tubular g-CN, an efficient dual-function catalyst for photocatalytic hydrogen production and NO removal.

Graphitic carbon nitride (g-CN) has emerged as a most promising photocatalyst, non-toxicity and low density, but it is plagued by low activity due to the small specific surface area and poor quantum efficiency. Morphological engineering and coupling with other materials to form hybrids have proven to be effective strategies for enabling high photocatalytic performances. Here, neodymium oxide (NdO) coupled tubular g-CN composites had been facilely synthesized by a solvent evaporation and high-temperature calcination method to realize efficient photocatalytic activity of hydrogen production and NO removal.

Measurement of the refractive index of whole blood and its components for a continuous spectral region.

The refractive index of blood is a key biophysical parameter, which can reflect the physiological state. We measured the refractive index of whole blood and other components, such as serum, plasma, and hemoglobin, based on internal reflection by using a homemade apparatus in the spectral range of 400 to 750 nm. In addition to the hemoglobin solution, which has a Soret band about 420 nm and two Q-bands between 500 and 600 nm, the measurements of other samples are the normal dispersion curve.

A potential risk factor of essential hypertension in case-control study: MicroRNAs miR-10a-5p.

: Essential hypertension is a multifactorial disease with high morbidity. The researches on the influence of genes on the disease are still in its infancy, and the mechanism of gene regulation is not clear. MiRNAs are key molecules that regulate the expression control of protein-coding or protein-non-coding RNA.

Complex Refractive Index Dispersion of Strong Absorbing Material Determined Using Internal Reflectance Spectra Measurement.

Complex refractive index dispersion (CRID) of offset inks is an important spectral property that affects the quality of printing. Due to the strong absorption of offset inks, great difficulty exists when measuring their CRID. In this study, a recently proposed apparatus that can detect the internal reflectance spectra was used to measure the CRID of three strong absorbing offset inks (magenta, yellow, and cyan).

A potential risk factor of essential hypertension in case-control study: Circular RNA hsa_circ_0037911.

Background: Essential hypertension (EH) is a high prevalence with multifactorial diseases. Human studies on the impact of genes on this disease are just in the initial stage, the mechanism of gene regulation is still remains unclear. Circular RNAs (circRNAs) as a continuous cycle of covalent closure, RNA molecules added to the 3'-5' end covalently bound by the formation of incidental event.

Perception, Knowledge and Behaviors Related to Typhoon: A Cross Sectional Study among Rural Residents in Zhejiang, China.

(1) The objective of this study was to assess the risk perceptions, attitudes, knowledge, and behaviors related to typhoon among rural residents in Zhejiang province of China. A cross-sectional study was conducted among rural residents in Zhejiang province, China. Information was collected from 659 participants using a structured questionnaire.

Quantitative index imaging of coculture cells by scanning focused refractive index microscopy.

We report the quantitative refractive index (RI) imaging of cocultured cells in their living environment by scanning focused refractive index microscopy (SFRIM). Mouse microglial cells and synovial cells are cocultured on the top surface of a trapezoid prism. The RI imaging of living cells is obtained in a reflection-type method.

Measurement of complex refractive index of turbid media by scanning focused refractive index.

We present the application of scanning focused refractive index microscopy in the complex refractive index measurement of turbid media. An extra standard scattering layer is placed in front of the detector to perform scattering transformation on the reflected light. The principle of the scattering transformation is elaborated theoretically.

[Analysis the relation of adults HBV vicinal failure and T cell subset, HLA-DR rang gene phenotype].

Objective: To study and explore the relativity of adults HBV vicinal failure and HLA-DR, T cell subset, trace viruses infection. To accumulate date for formulating preventing adult HBV infection prophylactic-therapeutic measures.

Methods: Select 20 adults randomly who had vaccinated with 10 microgYDV and produced anti-HBS successfully, and another 20 hadn't produced anti-HBs to form two groups-defeated group and contral group.