Downregulation of lncRNA MNX1-AS1 promotes the ferroptosis and apoptosis of non-small cell lung cancer.

Non-small cell lung cancer (NSCLC), the main histological type of lung cancer, poses a serious threat to human health. Increasing evidence has shown that long non-coding RNA (lncRNA) MNX1-AS1 is involved in the development and progression of cancers, including lung cancer. Apoptosis and ferroptosis, which are two forms of regulated cell death, can be induced by anti-cancer drugs.

Liquid-solid composites with confined interface behaviors.

In the evolving landscape of materials science, the journey from traditional composite materials to liquid-solid composites has marked a significant shift. Composite materials, typically solid state, have long been the cornerstone of many applications due to their structural stability and mechanical properties. However, the emergence of liquid-solid composites has introduced a new paradigm, leveraging the dynamic composite interfaces and fluidic nature of liquids.

A high-water retention, self-healing hydrogel thyroid model for surgical training.

The evaluation of thyroid lesions through Fine-Needle Aspiration Biopsy (FNAB) is a common procedure that requires advanced hand manipulation skills. Conventional training models for this procedure lack essential features such as tactile sensation and the ability to repeat punctures similar to those of real organs. To improve the quality of training, we have developed a hydrogel thyroid model that possesses features such as high-water retention and self-healing properties.

Gestational diabetes and future cardiovascular diseases: associations by sex-specific genetic data.

Background And Aims: Observational studies have highlighted that gestational diabetes mellitus is associated with a higher risk of cardiovascular diseases, but the causality remains unclear. Herein, the causality between genetic predisposition to gestational diabetes mellitus and the risk of cardiovascular diseases was investigated using sex-specific Mendelian randomization analysis.

Methods: Linkage disequilibrium score regression analysis and two-sample Mendelian randomization analysis were applied to infer the genetic correlation and causality, respectively.

Reconstructing the Surface of KSiF:Mn Phosphors toward Enhanced Moisture Resistance for White LED Applications.

The KSiF:Mn (KSFM) phosphor featuring efficient ultranarrow red emissions is an outstanding candidate for white light-emitting diode (WLED) applications. However, poor moisture resistance seriously affects its application performance. In this study, a two-step surface reconstruction strategy is proposed to dramatically enhance the moisture resistance of commercially available KSFM phosphors, involving treatment with HNbF and subsequent hydrothermal treatment.

Photothermal Particle-Loaded Panax Notoginseng Polysaccharide Cryogels As Personalized Tumor Vaccines.

Combination immunotherapy is being increasingly explored for cancer treatment, leading to various vector materials for the codelivery of immune agents and drugs. However, current tumor vaccines exhibit poor immunogenicity, severely compromising their therapeutic efficacy. Herein, an injectable hydrogel was developed based on dopamine (DA) and Panax notoginseng polysaccharide (PNPS) loaded with hair microparticles (HMPs) to enhance the immunogenicity of tumor vaccines.

High-Branched Natural Polysaccharide Flaxseed Gum Binder for Silicon-Based Lithium-Ion Batteries with High Capacity.

Silicon-based anodes heavily depend on the binder to preserve the unbroken electrode structure. In the present work, natural flaxseed gum (FG) is used as a binder of silicon nanoparticles (SiNPs) anode for the first time. Owing to a large number of polar groups and a rich branched structure, this material not only anchors tightly to the surface of SiNPs through bonding interactions but also formed a hydrogen bonding network structure among molecules.

Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis.

Background: Lung cancer is a serious threat to human health and is the first leading cause of cancer death. Ferroptosis, a newly discovered form of programmed cell death associated with redox homeostasis, is of particular interest in the lung cancer, given the high oxygen environment of lung cancer. NADPH has reducing properties and therefore holds the potential to resist ferroptosis.

Double-nylon purse-string suture in closing postoperative wounds following endoscopic resection of large (≥ 3 cm) gastric submucosal tumors.

Background: Endoscopic full-thickness resection (EFTR) of gastric submucosal tumors (SMTs) is safe and effective; however, postoperative wound management is equally important. Literature on suturing following EFTR for large (≥ 3 cm) SMTs is scarce and limited.

Aim: To evaluate the efficacy and clinical value of double-nylon purse-string suture in closing postoperative wounds following EFTR of large (≥ 3 cm) SMTs.

[Pollution Characteristics，Source Analysis，and Activity Analysis of Atmospheric VOCs During Winter and Summer Pollution in Zhengzhou].

In order to study the pollution characteristics of volatile organic compounds （VOCs）， continuous monitoring of VOCs in two pollution processes was conducted in June and December 2021 in Zhengzhou. Combined with meteorological conditions， the pollution characteristics， source contributions， and reactivity of VOCs in winter and summer were compared and analyzed. The results showed that the volume fraction of atmospheric VOCs in two episodes were （27.

Visual Biosensing with Specific Liquid-Based Interface Behaviors.

Liquid-based interface behaviors at micro/nano or even smaller scales induced by biomolecules take us into a fascinating realm, fostering a deeper understanding and innovation in visual biosensing. This biosensing technology, grounded in specific liquid-based interface behaviors, redefines how diseases can be detected, monitored, and diagnosed in resource-limited settings, providing rapid, cost-effective, and self-testing solutions to the current healthcare landscape. To date, the technology has witnessed significant advancements in visual sensing, driven by diverse liquid-based materials, advanced nanomanufacturing techniques, and a profound understanding of interface-material interactions.

Exposure to Short- and Medium-Chain Chlorinated Paraffins and the Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study in Eastern China.

Toxicological studies have indicated that exposure to chlorinated paraffins (CPs) may disrupt intracellular glucose and energy metabolism. However, limited information exists regarding the impact of human CP exposure on glucose homeostasis and its potential association with an increased risk of developing gestational diabetes mellitus (GDM). Here, we conducted a prospective study with a nested case-control design to evaluate the link between short- and medium-chain CP (SCCPs and MCCPs) exposures during pregnancy and the risk of GDM.

Towards Negative Emissions: Hydrothermal Carbonization of Biomass for Sustainable Carbon Materials.

The contemporary production of carbon materials heavily relies on fossil fuels, contributing significantly to the greenhouse effect. Biomass is a carbon-neutral resource whose organic carbon is formed from atmospheric CO. Employing biomass as a precursor for synthetic carbon materials can fix atmospheric CO into solid materials, achieving negative carbon emissions.

Inhibiting release of phenanthrene from rice-crab coculture sediments to overlying water with rice stalk biochar: Performance and mechanisms.

Rice crab coculture is a new ecological agriculture model combining rice cultivation and crab farming. Current research related to rice crab coculture only focuses on production theory and technical system establishment, while ignoring the potential ecological risk of Polycyclic aromatic hydrocarbon(PAHs) in rice crab coculture sediment. In this study, rice straw was used to make rice straw biochar to explore the performance and mechanism of inhibiting release of phenanthrene(PHE) from rice-crab coculture sediments to overlying water with rice stalk biochar.

Subcutaneous Rapid Dissolution Microneedle Patch Integrated with CuO and Disulfiram for Augmented Antimelanoma Efficacy through Multimodal Synergy of Photothermal Therapy, Chemodynamic Therapy, and Chemotherapy.

Melanoma is a malignancy of the skin that is resistant to conventional treatment, necessitating the development of effective and safe new therapies. The percutaneous microneedle (MN) system has garnered increasing interest as a viable treatment option due to its high efficacy, minimal invasiveness, painlessness, and secure benefits. In this investigation, a sensitive MN system with multiple functions was created to combat melanoma effectively.

Application of artificial intelligence in 3D printing physical organ models.

Artificial intelligence (AI) and 3D printing will become technologies that profoundly impact humanity. 3D printing of patient-specific organ models is expected to replace animal carcasses, providing scenarios that simulate the surgical environment for preoperative training and educating patients to propose effective solutions. Due to the complexity of 3D printing manufacturing, it is still used on a small scale in clinical practice, and there are problems such as the low resolution of obtaining MRI/CT images, long consumption time, and insufficient realism.

Opposite luminescence thermal behavior of upconversion core/shell nanocrystals for anticounterfeiting.

Inorganic luminescent materials generally suffer from thermal quenching due to accelerated nonradiative transitions at high temperature, whereas Yb sensitized core nanocrystals with small sizes (<30 nm) exhibit a temperature-dependent upconversion luminescence (UCL) enhancement. The related mechanism of the anomalous UCL thermal behavior is still under debate. In this work, we find that the UCL of NaGdF:Yb/Tm@NaGdF inert-shell nanocrystals declines at elevated temperature, while that of NaGdF:Yb/Ho@NaGdF:Yb active-shell ones is enhanced.

LESION MIMIC MUTANT 1 confers basal resistance to Sclerotinia sclerotiorum in rapeseed via a salicylic acid-dependent pathway.

Rapeseed (Brassica napus) is a major edible oilseed crop consumed worldwide. However, its yield is seriously affected by infection from the broad-spectrum non-obligate pathogen Sclerotinia sclerotiorum due to a lack of highly resistant germplasm. Here, we identified a Sclerotinia-resistant and light-dependent lesion mimic mutant from an ethyl methanesulfonate-mutagenized population of the rapeseed inbred Zhongshuang 11 (ZS11) named lesion mimic mutant 1 (lmm1).

Multifunctional high-simulation 3D-printed hydrogel model manufacturing engineering for surgical training.

Advanced bionic organ models with vivid biological structures and wetness and softness are essential for medical-surgical training. Still, there are many challenges in the preparation process, such as matching mechanical properties, good feedback on surgical instruments, reproducibility of specific surgical scenarios, and distinguishability between structural levels. In this paper, we achieved tissuemimicking dual-network (DN) hydrogels with customizable stiffness by adjusting the composition of the hydrogel matrix and the immersion time of the ionic solution to match different biological soft tissues precisely.

fabrication of a 3D self-supported porous Ni-Mo-Cu catalyst for an efficient hydrogen evolution reaction.

It is still a challenge to develop very effective and stable non-noble catalysts for the hydrogen evolution reaction (HER). Here, a self-supported porous Ni-Mo-Cu coating is prepared by the dynamic hydrogen bubble template (DHBT) method. This three-dimensional (3D) porous Ni-Mo-Cu coating can offer a large surface area, which helps expose more active sites and promote the transmission of electrons and materials.

The Tribological and Mechanical Properties of PI/PAI/EP Polymer Coating under Oil Lubrication, Seawater Corrosion and Dry Sliding Wear.

To investigate the tribological performance of a copper alloy engine bearing under oil lubrication, seawater corrosion and dry sliding wear, three different PI/PAI/EP coatings consisting of 1.5 wt% CeO, 2 wt% CeO, 2.5 wt% CeO were designed, respectively.