Effectiveness of hyperthermic intraperitoneal chemotherapy during primary curative resection for colorectal carcinoma.

Purpose: Peritoneal metastasis (PM) is the life-threatening cause of colorectal cancer patients (CRC). Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) plus cytoreductive surgery exhibited promising effects in preventing recurrence and increasing the survival of CRC patients. However, the outcomes of HIPEC on treating advanced CRC with risk of PM are still controversial.

Response strategies of five common warm temperate plant species to insect defoliation.

Under the background of global climate change, climate warming has led to an increase in insect herbivory, which significantly affects the growth, survival, and regeneration of forest plants in the warm temperate zone of China. Plants can adopt defense responses to adapt to insect defoliation. Therefore, field experiments were conducted on five common warm temperate species, Quercus acutissima, Quercus serrata, Quercus aliena, Quercus dentata, and Robinia pseudoacacia.

Why Are Widely Distributed Species Widely Distributed? Understanding From a Quantified Investment Acquisition Strategy.

Research on plant functional traits have advanced our understanding of plant investment acquisition strategies. However, it is still unknown how a plant investment acquisition strategy varies or how the relative position of plants on the leaf economic spectrum changes across different habitats. Therefore, we conducted the field experiments at two long-term ecological research sites in Shandong and Xinjiang, China, in August 2023.

Plant-derived artificial miRNA effectively reduced the proliferation of aphid (Aphidoidea) through spray-induced gene silencing.

Background: Aphids (Hemiptera: Aphididae) are notorious sap-sucking insects that rampantly threaten agricultural production worldwide. Current management against aphids in the field heavily relies on chemical pesticides, which makes economical and eco-friendly methods urgently needed. Spray-induced gene silencing (SIGS) offers a powerful and precise approach to pest management.

Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis.

Background: We have previously found that enhancer of zeste homolog 2 (EZH2) is correlated with inflammatory infiltration and mucosal cell injury in ulcerative colitis (UC). This study aims to analyze the role of X-inactive specific transcript (XIST), a possible interactive long non-coding RNA of EZH2, in UC and to explore the mechanisms.

Methods: C57BL/6N mice were treated with dextran sulfate sodium (DSS), and mouse colonic mucosal epithelial cells were treated with DSS and lipopolysaccharide (LPS) for UC modeling.

The combined effect of fire and nitrogen addition on biodiversity and herbaceous aboveground productivity in a coastal shrubland.

Introduction: Fire and nitrogen (N) deposition each impact biodiversity and ecosystem productivity. However, the effect of N deposition on ecosystem recovery after fire is still far from understood, especially in coastal wetlands.

Methods: We selected a typical coastal shrubland to simulate three N deposition levels (0, 10, and 20 g N m year) under two different burned conditions (unburned and burned) in the Yellow River Delta of North China.

lncRNA EGFEM1P promotes thyroid cancer progression by acting as an miR-369-3p sponge and upregulating TCF4.

Thyroid cancer is the most commonly diagnosed endocrine cancer, with the incidence of 14.42 per 100,000 person-years in 2010-2013. It is important to conduct an in-depth exploration into the molecular mechanisms of thyroid cancer, providing insights into the improvements of therapy.

CCCTC-Binding Factor Mediates the Transcription of Insulin-Like Growth Factor Binding Protein 5 Through EZH2 in Ulcerative Colitis.

Background: Ulcerative colitis (UC) features chronic, non-infectious inflammation of the colon. Insulin-like growth factor binding protein 5 (IGFBP5) has been indicated to be related to various inflammation-related diseases. However, its association with UC remains largely unclear.

A conserved asparagine residue in the inner surface of BRI1 superhelix is essential for protein native conformation.

Asparagine-linked glycosylation (ALG, N-glycosylation) is one of the most prevalent protein modifications in eukaryotes and regulates protein folding, trafficking and function. Recently, we reported that the mutation of N154Q significantly led to the ER retention of brassinosteroids insensitive 1 (BRI1), the receptor of brassinosteroids (BRs). However, the mechanism of how the N154 site affects BRI1 structure is still not completely clear.

Clinical observation of octreotide combined with diclofenac sodium in preventing ERCP-related pancreatitis.

Objective: To elucidate the efficacy of octreotide in combination with diclofenac sodium in the prevention of ERCP-related pancreatitis, and investigate its impact on patients' serum amylase, white blood cell (WBC) count, adverse effects, hyperamylasemia and hemorheology.

Methods: The prospective study was conducted, in which 124 patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) in our hospital were evenly divided into 2 groups, the observation group (n=62) and the control group (n=62), via a random number table method. The control group was administered diclofenac sodium lidocaine hydrochloride via injection after ERCP, while the observation group was given octreotide acetate on the basis of the control group.

Plant Size Plays an Important Role in Plant Responses to Low Water Availability and Defoliation in Two Woody Leguminosae Species.

Plant size influences plant responses to combined environmental factors under climate change. However, their roles in plant ecophysiological responses are not fully understood. Two rapidly growing Leguminosae species ( and ) were used to examine plant responses to combined drought and defoliation treatments (two levels of both treatments).

Biodiversity, environmental context and structural attributes as drivers of aboveground biomass in shrublands at the middle and lower reaches of the Yellow River basin.

Biodiversity-biomass relationships have been debated for decades and remain subject to controversy. Understanding the relationship between biodiversity and biomass will be crucial for soil and water conservation of the whole basin of the Yellow River. The positive effects of biodiversity on aboveground biomass are altered via two fundamental mechanisms-niche complementarity and selection effects-and are modulated by environmental context and community structure in natural communities.

Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma.

Background: The microliposome maintenance (MCM) complex, MCM2-7, is revealed to be involved in multiple cellular processes and plays a key role in the development and progression of human cancers. However, the MCM complex remains poorly elaborated in hepatic carcinoma (HCC).

Methods: In the study, we found the mRNA and protein level by bioinformatics.

Clinical Significance of Polo-Like Kinase 4 as a Marker for Advanced Tumor Stage and Dismal Prognosis in Patients With Surgical Gastric Cancer.

Objective: This study aimed to investigate the correlation of polo-like kinase 4 with clinicopathological features and survival profiles in patients with gastric cancer.

Methods: This retrospective study was conducted based on the clinical data from 289 eligible patients with gastric cancer who received resection. Polo-like kinase 4 expression in adjacent tissue and tumor tissue was determined by immunohistochemical assay and semiquantified scoring method using immunohistochemical score by staining intensity score multiplying staining density score.

Functional identity enhances aboveground productivity of a coastal saline meadow mediated by Tamarix chinensis in Laizhou Bay, China.

Research in recent decades has confirmed that biodiversity influences ecosystem productivity; however, the potential mechanisms regulating this process remain subject to controversy, due to variation across ecosystems. Here, the effects of biodiversity on ecosystem productivity were evaluated using three variables of biodiversity (taxonomic diversity, functional identity, and functional diversity) and surrounding environmental conditions in a coastal saline meadow located on the south coast of Laizhou Bay, China. At this site, the shrub and field layers were primarily dominated by Tamarix chinensis and natural mesic grasses, respectively.

Bacterial community shaped by heavy metals and contributing to health risks in cornfields.

Scientists are increasingly aware that heavy metal contamination in soils, especially in farmland ecosystems, can negatively affect human health and alter the bacterial community that plays a critical role in plant growth and heavy metal accumulation. The goal of the present paper was to uncover how various heavy metals and non-metallic elements affect human health and bacterial diversity in cornfields and to explore the contribution of soil bacteria to heavy metal accumulation in crops. Soil samples were collected from five counties in Shandong Province, China, where abnormally high levels of heavy metals and metalloids were caused by mining and heavy industry.