Publications by authors named "Shijia Liu"

Objective: To develop and validate a clinical combined radiomics model for predicting the treatment response and long-term survival prognosis of small cell lung cancer (SCLC) patients receiving platinum-based chemotherapy, as well as survival outcomes following chemoradiotherapy.

Methods: A total of 98 SCLC patients treated with platinum-based first-line chemotherapy were included in this study. Five prediction models for assessing the short-term efficacy of platinum-based first-line chemotherapy were developed using a logistic regression algorithm.

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Plants are subject to attack by diverse pests and pathogens. Few genes conferring broad-spectrum resistance to both insects and pathogens have been identified. Because of the growth-defense tradeoff, it is often challenging to balance biotic stress resistance and yield for crops.

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Floral organ identity is fundamental to species diversity and reproductive success in plants and is mainly determined by the combinatorial action of MADS homeotic factors. However, despite their conserved roles in specifying floral organ identity, the regulation of MADS transcription factors remains elusive. Here, we show that the rice (Oryza sativa L.

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The brain is rich in lipids, and disorders or abnormalities in lipid metabolism can induce neurotoxicity. Ceramides are the central intermediates of sphingolipid metabolism. This study was designed to investigate the potential lipotoxicity of ceramides in brain ischemia.

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Grain size is a key determinant of 1,000-grain weight, one of three factors determining grain yield. However, the complete regulatory network controlling grain size has not been fully clarified. Here, we identified a rice mutant, named small and round grain (srg) that exhibits semi-dwarf stature and small grain size.

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There are several meta-analyses about the comparison of tenofovir disoproxil fumarate (TDF) versus entecavir (ETV) for preventing hepatocellular carcinoma in patients with chronic HBV infection published in recent years. However, the conclusions vary considerably. This umbrella review aims to consolidate evidence from various systematic reviews to evaluate differences in hepatocellular carcinoma prevention between two drugs.

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Microbial corrosion has significant implications for the economy, environment, and human safety worldwide. Photocatalytic antibacterial technology, owing to its advantages in environmental protection, broad-spectrum, and efficient sterilization, presents a compelling alternative to traditional antibacterial strategies for microbial corrosion protection. In recent years, photocatalytic quantum dot materials have garnered considerable attention in this field due to their unique quantum effects.

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Detection of biomarkers was extremely important for the early diagnosis, prognosis, and therapy optimization of diseases. The purpose of this study was to investigate the differences in serum metabolites between patients with heart failure (HF) and healthy control (HC) and to diagnose HF qualitatively. In this study, serum samples from 83 patients with HF and 35 HCs were used as the research subjects for untargeted metabolomic analysis using ultraperformance liquid chromatography combined with quadrupole-time of flight mass spectrometry (UPLC-QTOF/MS) technology.

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Surfactin exhibits multifunctional properties, including antimicrobial, anti-inflammatory, and antitumor activities, positioning it as a promising novel food additive. However, its specific effects on the gut environment remain largely unexplored. To investigate this, we conducted in vitro fermentation simulations to assess the impact of surfactin on gut microbiota.

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Ultrafast laser processing technology exhibits exceptional precision and irreplaceable functionality in the fabrication of micron and nanometer-scale devices. However, its short action time presents challenges for observing and studying the interactions between ultrafast lasers and materials. This study employs molecular dynamics simulations to specifically investigate the application of ultrafast laser processing in treating amorphous structural defects on Ni-Fe alloy surfaces.

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Although breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem respiratory networks, which hitherto have received little characterization. Here we identify in mice a top-down breathing pathway from dorsal anterior cingulate cortex (dACC) neurons to pontine reticular nucleus GABAergic inhibitory neurons (PnC), which then project to the ventrolateral medulla (VLM). dACC→PnC activity correlates with slow breathing cycles and volitional orofacial behaviors and is influenced by anxiogenic conditions.

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Article Synopsis
  • The study examines the link between flavonoid intake and bone mineral density (BMD) and osteoporosis, utilizing data from NHANES to clarify inconsistent findings from previous research.
  • Analysis of 10,225 individuals revealed that higher flavonoid intake is associated with significantly increased BMD at various femur sites and reduced osteoporosis risk.
  • The research also identifies that the composite dietary antioxidant index (CDAI) plays a partial mediating role in the relationship between flavonoid intake and BMD.
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Key message A major quantitative trait locus (qGW12) for grain shape and weight has been isolated in rice, corresponding to LOC_Os12g17900/OsPUB23, and its encoded protein interacts with OsMADS1. Grain shape in rice is an important trait that influences both yield and quality. The primary determinants of grain shape are quantitative trait loci (QTLs) inherited from natural variation in crops.

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Nervous necrosis virus (NNV), a member of the Nodavirus genus, is a highly contagious disease that is found all over the world. As of right now, there aren't many reliable commercial vaccines available to combat this infection. In a previous study, we isolated a Mandarin fish (Siniperca chuatsi)-derived NNV strain, tentatively named MFNNV.

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  • Research on rice (Oryza sativa) shows that knocking out the lipoxygenase gene 1 with CRISPR/Cas9 helps maintain seed viability and quality during storage by slowing down the aging process.
  • Transcriptome analysis indicates that this gene knockout affects multiple metabolic pathways related to lipid metabolism and antioxidants, promoting better seed storability through regulation of various genes.
  • The findings suggest that this genetic modification could be beneficial for agricultural practices, as it enhances seed longevity without significantly altering other important agricultural traits.
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  • COPII vesicles are essential for transporting proteins from the endoplasmic reticulum (ER) to the Golgi apparatus in eukaryotic cells, but their functions in plants, particularly in rice seeds, are not fully understood.
  • The study identified the rice mutant gpa12, which is unable to export storage proteins from the ER, leading to abnormal protein accumulation, and found that it encodes a COPII protein, Sec13a, that is crucial for this process.
  • Additionally, researchers discovered that rice has two other Sec13 isoforms (Sec13b and Sec13c), which help maintain ER structure, highlighting the unique and overlapping roles of these proteins in regulating protein transport and ER morphology in rice endos
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  • Gout is a complex disease caused by the buildup of monosodium urate crystals in joints, and its causes are not fully understood, highlighting the need for new biomarkers for early detection and diagnosis.
  • A study analyzed serum samples from 47 gout patients and 49 healthy individuals using advanced metabolomics techniques, identifying 186 metabolites that significantly differed between the two groups, with 156 upregulated and 30 downregulated in gout patients.
  • Among the findings, indolelactic acid (ILA) emerged as a potential biomarker for gout, and the study suggested that pathways related to D-glutamine and D-glutamate metabolism may play crucial roles in the disease's development.
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Objective: This study aimed to unravel micro-processes that link information seeking to subsequent affective well-being (i.e., positive and negative affect) at the within-person level, as well as the role of worry as a mediator in this relationship.

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The application of CAR-T cells in solid tumors poses several challenges, including poor T cell homing ability, limited infiltration of T cells and an immunosuppressive tumor environment. In this study, we developed a novel approach to address these obstacles by designing GPC3-specific CAR-T cell that co-express IL-21 and CXCL9 (21 × 9 GPC3 CAR-T cells) and blocking the PD-1 expression on it. The proliferation, cell phenotype, cytokine secretion and cell migration of indicated CAR-T cells were evaluated in vitro.

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Background: Baitouweng decoction (BTW) is a classic botanical drugs formula that has been widely used clinically for the treatment of gut-related disorders in China. However, its role in ameliorating ulcerative colitis (UC) remains to be explored.

Purpose: The study aimed to determine the therapeutic efficacy and potential mechanism of action of BTW on dextran sodium sulfate (DSS)-induced colitis mice.

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Backgrounds: There is little evidence on the safety, efficacy, and survival benefit of restarting immune checkpoint inhibitors (ICI) in patients with cancer after discontinuation due to immune-related adverse events (irAEs) or progressive disease (PD). Here, we performed a meta-analysis to elucidate the possible benefits of ICI rechallenge in patients with cancer.

Methods: Systematic searches were conducted using PubMed, Embase, and Cochrane Library databases.

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2205 DSS is an excellent corrosion-resistant engineering metal material, but it is still threatened by microbiological corrosion. The addition of copper elements is a new approach to improving the resistance of 2205 DSS to microbiological corrosion. In this study, 2205-Cu DSS was compared with 2205 DSS to study its antimicrobial properties and resistance to microbiological corrosion in the presence of the electroactive bacterium Shewanella algae.

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  • Endosperm is crucial for grain yield and quality in cereal grains, with mitochondria providing the necessary energy for its development.
  • A study identified a rice mutant called floury endosperm26 (flo26) that results in abnormal starch grains, linked to a mitochondrial single-stranded DNA-binding protein (mtSSB1.1) discovered through cloning experiments.
  • The loss of mtSSB1.1 function disrupts gene transcription and RNA splicing of a key mitochondrial component, leading to decreased ATP production and highlighting its essential role in maintaining mitochondrial function and proper endosperm development in rice.
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In higher plants, mature male gametophytes have distinct apertures. After pollination, pollen grains germinate, and a pollen tube grows from the aperture to deliver sperm cells to the embryo sac, completing fertilization. In rice, the pollen aperture has a single-pore structure with a collar-like annulus and a plug-like operculum.

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