Progress and prospect of ASCT combined with CAR-T therapy in the treatment of multiple myeloma.

Multiple myeloma (MM) is a hematological cancer characterized by abnormal proliferation of plasma cells in bone marrow. In recent years, autologous stem cell transplantation (ASCT) has become the cornerstone of MM treatment. At the same time, immunotherapy, such as monoclonal antibody therapy and chimeric antigen receptor T cell (CAR-T) has also emerged, in which CAR-T is the most attractive focus.

Seasonal change of microplastics uptake in the Pacific oysters Crassostrea gigas cultured in the Yellow Sea and Bohai Sea, China.

This study investigated seasonal microplastics (MPs) pollution characteristics in oysters and surrounding surface seawater from five aquaculture farms located at the Yellow Sea and Bohai Sea. MPs abundances in oysters were 2.40 ± 0.

Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.

Oxidative stress induced by long-term cyclosporine A (CsA) administration is a major cause of chronic nephrotoxicity, which is characterized by tubular atrophy, tubular cell apoptosis, and interstitial fibrosis in the progression of organ transplantation. Although hydrogen-rich water (HRW) has been used to prevent various oxidative stress-related diseases, its underlying mechanisms remain unclear. This study investigated the effects of HRW on CsA-induced nephrotoxicity and its potential mechanisms.