Publications by authors named "Shihui Qin"

Article Synopsis
  • Synthetic polysaccharides can be utilized to design new drugs by examining their structure-activity relationships (SAR), particularly in terms of protein stability.
  • The study focuses on the glucan GLSWA-1 and its substructures, revealing that compound 2 enhances insulin secretion in a dose-dependent manner while maintaining insulin's thermal stability.
  • Molecular dynamics simulations indicate that compound 2 forms a "groove-binding model" with insulin, suggesting its potential as a hypoglycemic agent due to its favorable structural characteristics.
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Dictyophora rubrovalvata is a valuable fungus homologous to food and medicine, and its polysaccharide have been gaining increasing attention because of its plentiful activity. However, the structure and activity of its homogeneous polysaccharide have not been studied enough. In this study, two polysaccharides DRP-I and DRP-II were purified from D.

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Blume (), listed as one of the 34 precious Chinese medicines, servers a dual purpose as both a medicinal herb and a food source. Polysaccharide is the main active ingredient in , which has pharmacological activities such as immune regulation, anti-oxidation, anti-cancer, anti-aging, neuroprotection and antibacterial activity and so on. The biological activities of polysaccharide (GPs) is closely related to its chemical structures.

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Article Synopsis
  • The study investigated the flower branch of the TCM herb "Tianma" (Gastrodia elata), discovering 13 chemical compounds for the first time, including gastrodinols, flavonoids, and specialized compounds.
  • The research evaluated the antibacterial properties and cholinesterase inhibitory effects of these compounds, finding that some flavonoids demonstrated strong activity against methicillin-resistant Staphylococcus aureus.
  • Findings enhance the knowledge of the chemical makeup of "Tianma" and open up possibilities for new pharmacological uses of these compounds.
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Two new glycosides, ethyl--furanosyl-(1→6)-glucopyranoside () and (5-'')-galloyl-ethyl--furanosyl-(1→6)-glucopyranoside (), together with eight known compounds (-) were obtained from the -BuOH extraction of . Their structures were identified the extensive spectroscopic analysis. Compounds , exhibited the anti-inflammation activities, which inhibited the production of NO, TNF- and IL-1 in LPS-induced RAW264.

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Among the diversified glycan modifications, acylation is one of the most abundant. This modification could be responsible for many of the properties of glycans, such as structural stability and specificity for biological activity. To obtain better insight into the effects of acetylation of glycans on the structure and thermostability of insulin, it is critical to investigate glycans with a high degree of acetylation.

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Two new sesquiterpene glycosides, 8,12,15-trihydroxycopacamphan-15---D-glucopyranoside () and dendrobiumane C-11---D-glucopyranoside (), along with three known terpenoids () were isolated from the aerial stems of . Their structures were elucidated based on NMR-spectroscopic and HR-MS analyses. All compounds could reduce the levels of NO, TNF- and IL-1 in LPS-induced RAW264.

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As the two most principal active substances in the corn silk, polysaccharides and flavonoids, the mechanism of interaction between them has been a topic of intense research. This study provides an in-depth investigation of the interaction mechanism between corn silk glycans and luteoloside (LUT) and the synergistic role that result from this interaction. The interaction mechanism was evaluated by isothermal titration calorimetry (ITC) and circular dichroism (CD), and the synergistic role was evaluated by the expression of glucose transporters (GLUT-1), insulin secretion and surface plasmon resonance (SPR).

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Conjugated polymers have attracted considerable attention for thermoelectric applications in recent years due to their plentiful resources, diverse structures, mechanical flexibility, and low thermal conductivity. Herein, we demonstrate a new strategy of modulating charge carrier concentration of chemical-doped polymer films by modifying the substrate with self-assembled monolayers (SAMs). The SAM with a trifluoromethyl terminal group is found to accumulate holes in the polymer thin films, while the SAM with an amino terminal group tends to donate electrons to the polymer films.

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Hemoglobin (Hb) could be used as a substitute of peroxidase in the catalytic oxidation of tetra-substituted amino aluminum phthalocyanine (TAA1Pc) by H2O2. We found that the fluorescence of TAA1Pc (a red-region fluorescent dye with a maximum excitation wavelength at 606 nm and a maximum emission wavelength at 673 nm) could significantly be quenched by H2O2 in the presence of Hb. The value of F0/F (where the relative fluorescence intensity of blank solution and that of the sample solution containing Hb were given by F0 and F, respectively) is linearly related to the concentration of Hb.

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