Publications by authors named "Shihui Mo"
[Expression of S100A4 in mast cells and diagnostic values of serum S100A4 in allergic asthma].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
September 2024
Objective To preliminarily investigate the potential involvement of the calcium-binding protein S100A4 in the lipid metabolism of mast cells and its clinical significance in allergic asthma. Methods The allergic asthma-related expression matrix, GSE213085, was downloaded from the GEO database, and the data visualization were visualized by the R package. C57 mast cells were used for further knockdown of S100A4 by lentivirus transfection.
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- Multiple sclerosis (MS) is an autoimmune disease with no cure, and the protein S100A4 plays a role in regulating inflammation related to MS, although its exact mechanisms are unclear.
- Research involved manipulating S100A4 levels in mouse-derived microglia cells and studying its effects in an animal model of MS (EAE), revealing that mice with reduced S100A4 showed milder disease symptoms and less inflammation.
- Findings indicate that S100A4 could influence neuroinflammation by affecting microglial inflammation and cell death pathways, suggesting it may be a potential target for MS treatment.
S100A4 reprofiles lipid metabolism in mast cells via RAGE and PPAR-γ signaling pathway.
Int Immunopharmacol
February 2024
S100A4 is implicated in metabolic reprogramming across various cell types and is known to propel the progression of numerous diseases including allergies. Nonetheless, the influence of S100A4 on mast cell metabolic reprogramming during allergic disorders remains unexplored. Utilizing a mast cell line (C57), cells were treated with recombinant mouse S100A4 protein, with or without a PPAR-γ agonist (ROSI) or a RAGE inhibitor (FPS-ZM1).
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