Publications by authors named "Shiho Kubota"
Article Synopsis
- Immunocompromised COVID-19 patients experience longer viral shedding compared to those with normal immunity, but there's no universal guideline for safely ending their isolation as of August 2023.
- Comprehensive evaluations considering factors like mutant strains and patient immunity are crucial, and consulting infectious disease specialists is advised for better management.
- The study developed new isolation criteria based on patient classifications and clinical symptoms, highlighting the need for continuous updates using real-world data to improve these guidelines for non-specialists.
Objectives: Three-dimensional (3-D) printers are widely expected to provide a novel manufacturing method in the future to make personalized medicines in hospitals.
Methods: Functional filament containing 5-20% drug was prepared with rebamipide (REB; a poorly water-soluble model drug) and hypromellose phthalate (HPMCP; enteric base) at 130-170°C using a biaxial kneading extruder. Several tablet models with various internal structures were designed using computer-aided design.
IMP-type metallo-β-lactamase enzymes have been reported in different geographical areas and in various Gram-negative bacteria. However, the risk factors and epidemiology pertaining to IMP-type metallo-β-lactamase-producing Enterobacter cloacae (IMP-producing E. cloacae) have not been systematically evaluated.
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