Publications by authors named "Shiho Hanawa"
Article Synopsis
- * Despite negative tests for HIV and hepatitis B and C, the patient's immune response was found to involve anti-PR3-ANCA antibodies and hypocomplementemia.
- * Treatment with rituximab improved her kidney function and nephrotic syndrome symptoms, but did not help with her periodic fever; genetic testing suggested a rare mutation linked to adult-onset hereditary periodic fever.
Article Synopsis
- The study examines the long-term effects of aliskiren, a medication, on blood pressure in hypertensive patients undergoing hemodialysis.
- Among 25 patients, those who continued with aliskiren treatment saw significant reductions in blood pressure and levels of key hormones linked to blood pressure regulation over a 20-month period.
- The findings suggest that long-term use of aliskiren is effective in lowering blood pressure and inhibiting the renin-angiotensin-aldosterone system in these patients.
Article Synopsis
- A 61-year-old woman with multiple myeloma presented severe renal failure and anemia, with evidence of urinary Bence Jones protein leading to her hospital referral.
- A bone marrow biopsy showed high plasma cell levels, confirming her multiple myeloma diagnosis, while a kidney biopsy identified neoplastic plasma cell infiltration and other kidney damages.
- Despite treatment that improved her bone marrow condition, her renal function continued to decline, necessitating hemodialysis, indicating a need for more research on renal outcomes in multiple myeloma patients.
Background: Circulating prorenin contributes to the pathogenesis of tissue damage leading to cardiovascular disease (CVD) in hypertension and diabetic mellitus (DM) by activating the tissue renin-angiotensin-aldosterone (RAS) system; however, little is known about its roles in hemodialysis (HD) patients.
Methods: We evaluated plasma prorenin level and prorenin receptor [(P)RR] expression in peripheral blood mononuclear cells (PBMCs) in 49 nondiabetic HD (non-DM-HD) patients. Then we investigated the association between plasma prorenin level or (P)RR expression level in PBMCs and CVD-predictive biomarkers.
The renin-angiotensin-aldosterone system (RAAS) has pivotal roles in the pathogenesis of hypertension in hemodialysis-dependent chronic kidney disease (HDD-CKD) patients. Activated RAAS also increases inflammatory mediators by directly increasing proinflammatory gene expression and by putting oxidative stress on the vascular endothelium. Both hypertension and inflammation are major risk factors for cardiovascular disease (CVD) in HDD-CKD patients.
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