Publications by authors named "Shiheng Fan"

Objectives: The study aimed to examine the relationship between occupational factors and sleep disorders among employees in petrochemical enterprises.

Material And Methods: All participants from the employees of Hainan Petroleum Refining and Chemical Enterprises were recruited by the cluster sampling in June 1, 2022. The questionnaire used in this research was primarily composed of 3 sections: demographic characteristics, (PSQI) questionnaire and occupation-related factors affecting sleep disorders.

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Article Synopsis
  • A cross-sectional study was conducted with 841 workers in Hainan, China, to examine how oxidative stress mediates the relationship between low-concentration exposure to benzene, toluene, and xylene (BTX) and blood pressure.
  • The study found that workers exposed to BTX had higher levels of specific urinary metabolites (S-PMA, HA, and MHA) and higher diastolic blood pressure compared to a control group, suggesting an internal burden of BTX.
  • Correlation analysis indicated that higher levels of the benzene metabolite S-PMA were positively linked to increased diastolic blood pressure, while oxidative stress indicators showed lower antioxidant enzyme activity and higher oxidative damage in the exposed group. *
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Background: Activation of VDR pathway was a promising anti-tumor therapy strategy. However, numerous clinical studies have demonstrated the effect of activating VDR is limited, which indicates that VDR plays a complex role in vivos.

Methods: We analyzed the TCGA database to examine the association between VDR expression and immune cell infiltration in pancreatic adenocarcinoma (PAAD).

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Pheochromocytomas (PCCs) are rare neuroendocrine tumors that originate from chromaffin cells in the adrenal gland. However, the cellular molecular characteristics and immune microenvironment of PCCs are incompletely understood. Here, we performed single-cell RNA sequencing (scRNA-seq) on 16 tissues from 4 sporadic unclassified PCC patients and 1 hereditary PCC patient with Von Hippel-Lindau (VHL) syndrome.

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Article Synopsis
  • * Researchers used techniques like digital spatial profiling and multiplex immunofluorescence to analyze tumor biopsies, identifying high levels of HLA-DR/MHC-II and CD20+ B cells as potential predictors of nCRT effectiveness.
  • * The study found that spatial profiling of the tumor microenvironment (TME) can help predict individual responses to nCRT, opening doors for more personalized cancer treatment strategies.
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Both specific and innate immune responses play important roles in autoimmune encephalitis (AE). We aimed to explore the predictive value of the systemic inflammation index (SII) at admission as a peripheral biomarker of treatment response of AE. A total of 146 patients diagnosed with AE in the First Affiliated Hospital of Zhengzhou University from January 1, 2018 to September 22, 2020 were retrospectively and consecutively analyzed as per the inclusion criteria and divided into two groups according to their response to immunotherapy after 30 days.

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The clinical manifestations of neuronal intranuclear inclusion disease (NIID) are heterogeneous, and the premortem diagnosis is mainly based on skin biopsy findings. Abnormal GGC repeat expansions in was recently identified in familial and sporadic NIID. The comparison of diagnostic value between abnormal GGC repeat expansions of and skin biopsy has not been conducted yet.

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Rationale: Isoelectric focusing electrophoresis (IFE) is currently recognized as the gold standard for detecting oligoclonal bands (OCBs) in cerebrospinal fluid (CSF). To the best of our knowledge, however, no study has reported on type III OCBs using IFE. In this paper, we report on a rare case of multiple myeloma (MM) with Echinococcus granulosus infection diagnosed by IFE.

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Objective: Recent studies demonstrated cutaneous phosphorylated α synuclein (p-syn) deposition in idiopathic and some monogenetic Parkinson disease (PD) patients, suggesting synucleinopathy identical to that in the brain. Although the LRRK2 Gly2385Arg (G2385R) variant is a common PD risk factor in the Chinese population, the pathogenesis of PD with G2385R variant has not been reported. We investigated whether synucleinopathy and small fiber neuropathy (SFN) are associated with the G2385R variant.

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NOTCH2NLC GGC repeat expansions were recently identified in neuronal intranuclear inclusion disease (NIID); however, it remains unclear whether they occur in other neurodegenerative disorders. This study aimed to investigate the role of intermediate-length NOTCH2NLC GGC repeat expansions in Parkinson disease (PD). We screened for GGC repeat expansions in a cohort of 1,011 PD patients and identified 11 patients with intermediate-length repeat expansions ranging from 41 to 52 repeats, with no repeat expansions in 1,134 controls.

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