Publications by authors named "Shihao He"

Moyamoya disease (MMD), a chronic cerebrovascular disorder, is characterized by progressive stenosis of major intracranial arteries. However, the mechanisms underlying the pathological narrowing have remained largely elusive. Disulfidptosis is a new mode of cell death caused by the vulnerability of the actin cytoskeleton to disulfide stress, and proteomic profiling of MMD has revealed that abnormal proliferation of endothelial cells may be induced by upregulation of focal adhesion-related proteins.

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Patients with arteriovenous malformations (AVMs) located in the functional area of speech often exhibit language dysfunction, and neuroplasticity allows the brain of some patients to regain speech through functional reorganization. Exploring the mechanism of AVMs-induced reorganization of language function is important for understanding neuroplasticity and improving clinical intervention strategies. This review systematically searched and analyzed the research literature in related fields in recent years, covering data from neuroimaging, functional magnetic resonance imaging (fMRI), and clinical case studies.

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Moyamoya disease (MMD) is a rare chronic vascular disease leads to cognitive impairment and stroke with its etiology unknown. The relationship between necroptosis or necroinflammation and MMD pathogenesis was poorly understood. Differentially expressed necroinflammation and necroptosis related genes (DE-NiNRGs) were selected based on the public gene expression data from Gene Expression Omnibus (GEO) and validated by our self-test data of MMD patients and control group.

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Unilateral moyamoya disease (U-MMD) is a chronic vascular disease characterized by progressive stenosis and occlusion of the terminal end of the internal carotid artery and its main branches, resulting in the appearance of moyamoya-like blood vessels at the base of the brain. The etiology of U-MMD is unknown, it accounts for 9.7-17.

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Moyamoya disease (MMD) is a type of cerebrovascular disease characterized by occlusion of the distal end of the internal carotid artery and the formation of collateral blood vessels. Over the past 20 years, the landscape of research on MMD has significantly transformed. In this review, we provide insights into the pathogenesis, diagnosis, and therapeutic interventions in MMD.

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Cognitive dysfunction is common in Moyamoya disease (MMD). However, current knowledge of cognitive impairment in MMD is inadequate. In this review, we explored the characteristics of altered cognitive function associated with MMD and offered recommendations aimed at guiding potential research endeavors into the cognitive dysfunction in MMD.

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Background & Aims: The risk of mother-to-child transmission (MTCT) for pregnant women with chronic hepatitis B (CHB) still exists, especially for those with high HBV DNA levels. The guidelines for initiating prophylaxis for pregnant women with CHB vary across countries. We aimed to explore the latest prophylaxis initiation time for these women.

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Article Synopsis
  • Tin oxide (SnO) is widely used in perovskite solar cells but faces challenges due to defects that hinder charge transport.
  • Doping SnO with ZnF effectively reduces these defects, improving electron transfer and decreasing energy loss from nonradiative recombination.
  • The hybrid ETL enhances solar cell performance, achieving power conversion efficiencies of 21.31% and 24.91% for different perovskite types while maintaining about 90% efficiency after 600 hours of storage.
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  • Moyamoya disease (MMD) is a chronic brain disorder that can cause strokes and neurological issues, and researchers are investigating its epigenetic factors.
  • A study analyzed DNA methylation in two different groups of adult female patients with MMD, finding low variability in methylation patterns between patients and healthy controls.
  • The low methylation variability may limit patients' ability to adapt to environmental changes, potentially impacting vascular health and furthering MMD pathology, suggesting new avenues for treatment.
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Moyamoya disease (MMD) is a chronic cerebrovascular disease that can lead to ischemia and hemorrhagic stroke. The relationship between oxidative phosphorylation (OXPHOS) and MMD pathogenesis remains unknown. The gene expression data of 60 participants were acquired from three Gene Expression Omnibus (GEO) datasets, including 36 and 24 in the MMD and control groups.

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Tin dioxide (SnO), in perovskite solar cells (PSCs), stands out as the material most suited to the electron transport layer (ETL), yielding advantages with regard to ease of preparation, high mobility, and favorable energy level alignment. Nonetheless, there is a chance that energy losses from defects in the SnO and interface will result in a reduction in the . Consequently, optimizing the interfaces within solar cell devices is a key to augmenting both the efficiency and the stability of PSCs.

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Article Synopsis
  • - Moyamoya disease (MMD) is a serious condition that causes narrowing of the internal carotid artery and creates a fragile network of blood vessels at the base of the brain, but the involvement of PANoptosis in MMD hasn't been explored yet.
  • - In this study involving 40 patients, researchers identified 815 genes linked to MMD, highlighting five key genes—DNAJA3, ESR1, H19, KRT18, and STK3—that are connected to immune responses and various signaling pathways related to the disease.
  • - The study also created a regulatory network for these genes and identified potential therapeutic drugs (MST-312, bisacodyl, indirubin, and tropanyl-3,5
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Introduction: The Joint United Nations Programme on HIV/AIDS (UNAIDS) updated the 95-95-95 targets for the HIV endgame in 2030. To achieve the first target in a timely manner, we investigate the optimized strategy of resource allocation to maximize timely HIV diagnosis in 14 populations in China.

Methods: We developed a mathematical model by integrating epidemiological, demographical and behavioural data from 12 high-risk and two general populations to evaluate the impact of various resource allocation strategies of HIV testing on HIV incidence in China.

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Background: To identify potential serum biomarkers for differentiating between axial psoriatic arthritis (axPsA) and peripheral psoriatic arthritis (pPsA).

Methods: Serum samples were collected from patients with PsA to create a biomarker discovery cohort and a verification cohort. Patients with PsA were classified into axial or peripheral subtypes based on imaging criteria.

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Moyamoya disease (MMD) is a rare cerebrovascular disorder marked by progressive stenosis of the internal carotid arteries. Assessing cerebral hemodynamics, specifically cerebrovascular reactivity (CVR), is vital for MMD management and prognosis. In this study, fMRI was performed in a prospective cohort of 47 patients with MMD and 32 healthy controls to investigate its utility in evaluating CVR and to explore the influence of cerebral posterior circulation compensation on CVR in MMD.

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Two-dimensional transition-metal chalcogenides (TMCs) have attracted considerable attention because of their exceptional photoelectric properties, finding applications in diverse fields such as photovoltaics, lithium-ion batteries, catalysis, and energy conversion and storage. Recently, experimentally fabricated monolayers of semiconducting CuTe have emerged as intriguing materials with outstanding thermal and photoelectric characteristics. In this study, we employ first-principles calculations to investigate the mechanical, electronic, and optical properties of monolayer CuTe exhibiting both λ and ζ structures, considering the effects of thickness and strain.

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Article Synopsis
  • * Male patients showed earlier onset of PsA, higher rates of axial involvement, and worse clinical scores compared to female patients, who had higher rates of peripheral arthritis.
  • * Despite these differences, both sexes had similar rates of achieving disease remission, indicating that the impact of PsA varies significantly between males and females in terms of health-related quality of life.
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Background: Moyamoya disease (MMD) is a rare progressive vascular disease that leads to intracranial internal carotid artery stenosis and eventual occlusion. However, its pathogenesis remains unclear. The purpose of this study is to explore the role of abnormally expressed proteins in the pathogenesis of MMD.

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Moyamoya disease (MMD) is a chronic and progressive cerebrovascular stenosis or occlusive disease that occurs near Willis blood vessels. The aim of this study was to investigate the mutation of DIAPH1 in Asian population, and to compare the angiographic features of MMD patients with and without the mutation of the DIAPH1 gene. Blood samples of 50 patients with MMD were collected, and DIAPH1 gene mutation was detected.

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The association of exosomal RNA profiling and pathogenesis of moyamoya disease (MMD) and intracranial Atherosclerotic disease (ICAD) is unknown. In this study, we investigated the RNA profiles of sEV (small extracellular vesicles)/exosomes in patients with MMD and ICAD. Whole blood samples were collected from 30 individuals, including 10 patients with MMD, 10 patients with ICAD, and 10 healthy individuals.

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Background: COVID-19 and diabetes both contribute to large global disease burdens.

Purpose: To quantify the prevalence of diabetes in various COVID-19 disease stages and calculate the population attributable fraction (PAF) of diabetes to COVID-19-related severity and mortality.

Data Sources: Systematic review identified 729 studies with 29,874,938 COVID-19 patients.

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