Publications by authors named "Shihan Zhou"

Article Synopsis
  • Renal fibrosis (RF) is a disease where excessive extracellular matrix buildup occurs, activating signaling pathways related to tissue repair and fibrosis, particularly affecting tubular epithelial cells (TECs).
  • The article highlights key biological mechanisms and pathways involved in RF, including cellular senescence, ferroptosis, autophagy, epithelial-mesenchymal transition, and the TGF-β/Smad signaling pathway.
  • A review of traditional Chinese medicine (TCM) finds promising results in using Chinese herbs to reduce RF and prevent chronic kidney disease (CKD), suggesting new strategies for treatment and clinical applications.
View Article and Find Full Text PDF
Article Synopsis
  • A new study investigates the effectiveness of combining pyrotinib, a targeted therapy, with metronomic oral etoposide chemotherapy in patients with heavily pretreated HER2-positive metastatic breast cancer (MBC). !* -
  • Results from 22 patients show a median progression-free survival (PFS) of 9.0 months and overall survival (OS) of 27.0 months, indicating that the treatment is both effective and tolerable. !* -
  • The combination treatment yielded a 30% objective response rate and an 80% disease control rate, with manageable side effects primarily including nausea, vomiting, and diarrhea. !*
View Article and Find Full Text PDF
Article Synopsis
  • CDK4/6 inhibitors in combination with endocrine therapy have become key treatments for hormone receptor-positive advanced breast cancer, and ongoing research explores the benefits of switching to a different CDK4/6 inhibitor after disease progression.
  • In a study of 82 patients who switched CDK4/6 inhibitors, the median progression-free survival was 7.6 months, with some patients experiencing up to 10.7 months of survival after switching therapies.
  • The study identified lung metastasis and switching to endocrine therapy as factors that could influence treatment outcomes, with hematologic toxicity being the most common severe side effect observed.
View Article and Find Full Text PDF

Unlabelled: The incidence of Parkinson's disease (PD) rises rapidly with the increase of age. With the advent of global aging, the number of patients with PD is rising along with the elderly population, especially in China. Previously, we found that Yishen chuchan decoction (YCD), prescribed based on clinical experience, has the potential of alleviating symptoms, delaying the progression, and controlling the development of PD.

View Article and Find Full Text PDF

Background: Inetetamab is the first domestically developed innovative anti-HER2 monoclonal antibody in China, proven effective and safe in HER2-positive advanced breast cancer. However, its efficacy and safety in neoadjuvant treatment of HER2-positive locally advanced breast cancer (LABC) remain to be validated.

Methods: This prospective cohort study aimed to evaluate the efficacy and safety of inetetamab combined with pertuzumab, taxanes, and carboplatin (TCbIP) in neoadjuvant therapy for HER2-positive LABC, comparing it to data from patients treated with the TCbHP regimen (trastuzumab combined with pertuzumab, taxanes, and carboplatin) using propensity score matching (PSM).

View Article and Find Full Text PDF

Crafting an inorganic semiconductor heterojunction with defect engineering and morphology modulation is a strategic approach to produce clean energy by the highly efficient light-driven splitting of water. In this paper, a novel Z-scheme sulfur-vacancy containing ZnInS (Vs-ZnInS) nanosheets/InO hollow hexagonal prisms heterostructrue (Vs-ZIS6INO) was firstly constructed by an oil bath method, in which Vs-ZnInS nanosheets grew on the surfaces of InO hollow hexagonal prisms to form a hollow core-shell structure. The obtained Vs-ZIS6INO heterostructrue exhibited much enhanced activity of the production of H and HO by the light-driven water splitting.

View Article and Find Full Text PDF
Article Synopsis
  • This study explored a clinical isolate (W986) that showed resistance to the antibiotic fosfomycin and characterized the resistance gene and the enzymatic activity of a newly identified enzyme called FosA11.
  • Using advanced genomic sequencing and laboratory techniques, researchers determined that the presence of FosA11 contributes significantly to fosfomycin resistance by showing a 32-fold increase in its minimum inhibitory concentration (MIC).
  • The study highlights the urgent need to understand the molecular mechanisms of fosfomycin resistance as its prevalence increases among Enterobacterales, with FosA11 being a novel potential target for further research.
View Article and Find Full Text PDF

Ethnopharmacological Relevanc: Pyrolae herba (PH), a kind of Chinese herb, has been identified to have an anti-inflammatory effect, while the potential for treating cognitive impairment (CI), as well as the underlying mechanisms, is unclear. Currently, the interaction between neuroinflammation and neural function play a critical role in pathophysiology of CI.

Aim Of The Study: To elucidate therapeutic effect of PH for CI as well as its underlying mechanisms with LPS-treated mice model.

View Article and Find Full Text PDF

Ethnopharmacological Relevance: Treating cognitive impairment is a challenging and necessary research topic. ZeXieYin Formula (ZXYF), is a traditional herbal formula documented in the book of HuangDiNeiJing. Our previous studies demonstrated the ameliorative effects of ZXYF on atherosclerosis by reducing the plasma trimethylamine oxide (TMAO) level.

View Article and Find Full Text PDF

Mild cognitive impairment (MCI) is an intermediate state between "healthy" and "dementia", which affects memory and cognitive function. Timely intervention and treatment of MCI can effectively prevent it from developing into an incurable neurodegenerative disease. Lifestyle factors, such as dietary habits, were highlighted as risk factors for MCI.

View Article and Find Full Text PDF

As a new source of natural fibers, the Bombax ceiba tree can provide thin, light, extremely soft and warm fiber material for the textile industry. Natural fibers are an ideal model system for studying cell growth and differentiation, but the molecular mechanisms that regulate fiber initiation are not fully understood. In B.

View Article and Find Full Text PDF

Abscisic acid (ABA) is a plant hormone that plays an important role in cotton fiber development. In this study, the physiological changes and proteomic profiles of cotton (Gossypium hirsutum) ovules were analyzed after 20 days of ABA or ABA inhibitor (ABAI) treatment. The results showed that compared to the control (CK), the fiber length was significantly decreased under ABA treatment and increased under ABAI treatment.

View Article and Find Full Text PDF

(1) Background: This study aimed to explore the relationship between years of participation, subjective exercise experience, and group cohesion among gender-specific square dance practitioners. (2) Methods: The Subjective Exercise Experience Questionnaire (SEEQ) and Group Environment Questionnaire (GEQ) were used to evaluate Subjective Exercise Experience (SEE) and group cohesion (GC). An analysis was conducted on 130 Chinese (63 males and 67 females) using multiple group analysis within a structural equation model.

View Article and Find Full Text PDF