Publications by authors named "Shih-Feng Shieh"
Int J Mol Sci
February 2022
Article Synopsis
- MicroRNAs (miRNAs) regulate gene expression by either degrading or inhibiting the translation of specific mRNAs, and their interactions can explain indirect relationships among different mRNAs in the body.
- Current research suggests that the involvement of the proteins produced from these targeted mRNAs has not been adequately examined in the competition dynamics of competing endogenous RNA (ceRNA) networks.
- A new deterministic model indicates that significant changes in the levels of mRNAs targeted by miRNAs also depend on the transcriptional inhibition of miRNAs by those target proteins, especially observed in ovarian cancer scenarios where miR-193a's epigenetic silencing by E2F6 is crucial for altering the levels of c-KIT and PBX1 associated with
