Publications by authors named "Shigong Chen"
Article Synopsis
- Cadonilimab combined with FLOT chemotherapy shows potential as a neoadjuvant treatment for locally advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma, based on a multicenter trial in China.
- The trial involved treatment-naive patients, achieving a 100% R0 resection rate, a 21.1% pathological complete response rate, and a 44.7% major pathological response rate, indicating significant tumor reduction.
- The treatment had manageable side effects, with 31.6% of patients experiencing grade 3 adverse events, suggesting further research is warranted to explore its efficacy and safety.
Oral propranolol has not been shown to impact physical development, such as weight and height. The impact of children's intellectual development has received relatively little attention from researchers. The effects of propranolol on the growth and development of children with proliferative infantile hemangiomas during treatment were analyzed retrospectively.
View Article and Find Full Text PDFA kinetics model was developed for predicting and simulating immobilized cellulase performance, which follows Michaelis-Menten kinetics with competitive product inhibition. Taking into account the effects of competitive product inhibition, inner diffusional limitation, substrate concentration and carrier size, the substrate distribution and the product distribution in carriers were investigated, and the effectiveness factors were also calculated over a wide range of parameters. The effects of competitive product inhibition are shown to increase the substrate concentration in the carrier, and, additionally, to increase the effectiveness factors slightly.
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