Publications by authors named "Shigeyuki Kobayashi"
Article Synopsis
- - A 46-year-old Japanese man had a very high eosinophil count and elevated liver enzymes, leading to a diagnosis involving acute liver injury and deep vein thrombosis.
- - Imaging tests showed large clots in his femoral veins, and a liver biopsy indicated significant liver damage and inflammation.
- - Despite treatment with steroids and heparin, the patient suffered a cardiac arrest due to clots in his lungs and unfortunately passed away despite emergency interventions.
Brain activity following esophageal acid infusion using positron emission tomography.
World J Gastroenterol
November 2010
Aim: To investigate symptoms and brain activity following esophageal acid infusion.
Methods: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2) and distilled water (pH 7) were randomly and repeatedly infused into the esophagus.
Aim: To test this hypothesis of barrett esophagus (BE) classified into two types and to further determine if there was any correlation between the shape of endoscopically suspected esophageal metaplasia (ESEM), prevalence of reflux esophagitis (RE) and heartburn.
Methods: A total of 6504 Japanese who underwent endoscopy for their annual stomach check-up were enrolled in this study. BE was detected without histological confirmation that is ESEM.
Aim: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg.
Methods: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug.
Aim: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose.
Methods: Eight H pylori -negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was performed on the day of treatment.
Aim: To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan.
Methods: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged>40 years.