Publications by authors named "Shigeyoshi Takamizawa"
Objectives: This study explored the impacts of peri-operative changes in the neutrophil-to-lymphocyte ratio (NLR) on the survival rate after radical nephroureterectomy.
Methods: This retrospective analysis included a multicentric cohort of patients diagnosed with upper tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy from 2012 to 2021. We assessed the preoperative NLR, postoperative NLR, delta-NLR (difference between postoperative and preoperative NLRs), and NLR change (ratio of postoperative to preoperative NLR).
Article Synopsis
- - A study analyzed the effectiveness of two drugs, enzalutamide and apalutamide, in treating patients with non-metastatic castration-resistant prostate cancer (nmCRPC) to understand their efficacy and adverse event (AE) profiles.
- - The research involved 191 patients, revealing that both drugs led to similar oncological outcomes, with comparable PSA response rates and no significant differences in progression-free survival (PFS) or overall survival (OS).
- - However, the side effects varied, with enzalutamide causing more fatigue and apalutamide leading to more skin rashes, indicating their differential usage may depend on AE profiles despite similar efficacy.
Background: With the development of kidney-sparing surgery and neoadjuvant chemotherapy, ureteroscopic biopsy (URSBx) has become important for the management of upper tract urothelial carcinoma (UTUC).
Methods: We retrospectively analyzed data from 744 patients with UTUC who underwent radical nephroureterectomy (RNU), stratified into no ureteroscopy (URS), URS alone, and URSBx groups. Intravesical recurrence-free survival (IVRFS) was examined using the Kaplan-Meier method.