Publications by authors named "Shigetoshi Tsutsumi"
Article Synopsis
- - Brazilian propolis (AF-08), rich in flavonoids and used as folk medicine, may help reduce cardiovascular disease risk by inhibiting platelet aggregation, which is linked to thrombus formation.
- - In laboratory tests, AF-08 demonstrated significant inhibition of collagen-induced platelet aggregation without affecting blood coagulation metrics like prothrombin time and activated partial thromboplastin time.
- - The flavonoids found in AF-08, particularly apigenin and chrysin, are suggested to play a key role in preventing platelet aggregation, potentially lowering the risk of arterial thrombus formation and cardiovascular diseases.
As obesity is a global health concern the demand for anti-obesity drugs is high. In this study, we investigated the anti-obesity effect of the dried branches and leaves of murta (Myrceugenia euosma Legrand, Myrtaceae). A methanol extract of the dried branches and leaves of murta inhibited adipogenesis in 3T3-L1 cells.
View Article and Find Full Text PDFEffect of Brazilian propolis (AF-08) on genotoxicity, cytotoxicity and clonogenic death of Chinese hamster ovary (CHO-K1) cells irradiated with (60)Co gamma-radiation.
Mutat Res Genet Toxicol Environ Mutagen
March 2014
The present study was conducted in order to evaluate the effect of Brazilian propolis (AF-08; 5, 10, 15, 30, 50, 100, and 200μg/mL) in protecting CHO-K1 cells against genotoxic and cytotoxic damage and clonogenic death induced by (60)Co gamma-radiation (1.0, 2.0, 4.
View Article and Find Full Text PDFTetrabromobisphenol A (TBBPA), a brominated flame retardant, has been found to exacerbate pneumonia in respiratory syncytial virus- (RSV-) infected mice. We examined the effect of Brazilian propolis (AF-08) on the exacerbation of RSV infection by TBBPA exposure in mice. Mice were fed a powdered diet mixed with 1% TBBPA alone, 0.
View Article and Find Full Text PDF